A5042069922- Salivary Gland Disorders and Functions
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Hedgehog Signaling Pathway Studies
- Genetic Associations and Epidemiology
- Neonatal Respiratory Health Research
- Hearing, Cochlea, Tinnitus, Genetics
- Forensic and Genetic Research
- Single-cell and spatial transcriptomics
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- Noise Effects and Management
- Molecular Biology Techniques and Applications
- Hearing Loss and Rehabilitation
Albany State University
2021-2024
University at Albany, State University of New York
2021-2024
University at Buffalo, State University of New York
2018
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren's Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally induce a...
Vascular endothelial cells have important tissue-specific functions in fibrosis and regeneration. In the salivary gland, are required for proper development, but their roles within adult glands largely unknown. To identify ligand-receptor interactions between other cell types that may be during regeneration, we used a reversible ductal ligation injury. induce injury, clip was applied to primary ducts 14 d, regenerative response, subsequently removed 5 d. cell-produced factors, single-cell...
Plasticity in the medial and lateral olivocochlear (MOC LOC) systems response to chronic exposure background noise was investigated. Three different age-groups of young mice were exposed same moderate conditions with either immediate tissue harvest or following restoration quiet conditions, age matched controls. Cochleae dissected standard immunohistochemistry protocols used label hair cells antibodies against myosin 6 synaptic terminals vesicle protein 2 (SV2). Specimens imaged using...
Abstract Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally...
Fibrosis results from excess extracellular matrix deposition, which alters normal tissue architecture and impedes function. Salivary gland fibrosis can be caused by irradiation therapy, as a treatment for head neck cancer, well the autoimmune disease Sjögren's Syndrome. The mechanisms that contribute to are complex poorly understood; however, defining cell types signaling pathways involved could reveal potential therapeutic targets. Stromal subpopulations have been shown fibrosis....