A5019403113- Salivary Gland Disorders and Functions
- Mesenchymal stem cell research
- Head and Neck Cancer Studies
- Neonatal Respiratory Health Research
- Single-cell and spatial transcriptomics
- Salivary Gland Tumors Diagnosis and Treatment
- dental development and anomalies
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Hedgehog Signaling Pathway Studies
- Mitochondrial Function and Pathology
University at Albany, State University of New York
2019-2024
Albany State University
2019-2024
University of North Carolina at Chapel Hill
2024
New York University
2019
SUNY Brockport
2015
Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren's Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally induce a...
Vascular endothelial cells have important tissue-specific functions in fibrosis and regeneration. In the salivary gland, are required for proper development, but their roles within adult glands largely unknown. To identify ligand-receptor interactions between other cell types that may be during regeneration, we used a reversible ductal ligation injury. induce injury, clip was applied to primary ducts 14 d, regenerative response, subsequently removed 5 d. cell-produced factors, single-cell...
Stromal cells can direct the differentiation of epithelial progenitor during organ development. Fibroblast growth factor (FGF) signaling is essential for submandibular salivary gland Through stromal fibroblast cells, FGF2 indirectly regulate proacinar cell in organoids, but mechanisms are not understood. We performed single-cell RNA-sequencing and identified multiple subsets, including Pdgfra+ subsets expressing both Fgf2 Fgf10. When combined with magnetic-activated cell-sorted PDGFRα+...
Regenerative medicine aims to repair, replace, or restore function tissues damaged by aging, disease, injury. Partial organ resection is not only a common clinical approach in cancer therapy but also an experimental injury model used examine mechanisms of regeneration and repair organs. We performed partial resection, sialoadenectomy, the female murine submandibular salivary gland (SMG) establish for investigation glands (SGs). After we whole-gland measurements over period 56 d found that...
Abstract Vascular endothelial cells have important functions in fibrosis via direct and indirect methods regeneration through secretion of tissue-specific, paracrine-acting angiocrine factors. In the salivary gland, are required for proper development, but their roles within adult glands largely unknown. The goal this work was to identify ligand-receptor interactions between other cell types that during homeostasis, fibrosis, regeneration. To model gland regeneration, we utilized a...
3.0 Abstract Stromal cells can direct epithelial differentiation during organ development; however, these pathways remain poorly defined. FGF signaling is essential for submandibular salivary gland development, and FGF2 regulate proacinar cell in organoids through autocrine stromal cells. We performed scRNA Seq identified subsets expressing Fgf2 Fgf10 that also express Pdgfrα . When combined with organoids, MACS-sorted PDGFRα + sufficiently promoted differentiation. Gene expression analysis...
Abstract Regenerative medicine aims to repair, replace, or restore function tissues damaged by aging, disease, injury. Partial organ resection is not only a common clinical approach in cancer therapy, it also an experimental injury model used examine mechanisms of regeneration and repair organs. We performed partial resection, sialodenectomy, the murine submandibular salivary gland (SMG) establish for investigation glands (SGs). After sialoadenectomy we whole measurements over period 56 days...
Abstract Fibrosis results from excess extracellular matrix accumulation, which alters normal tissue architecture and impedes function. In the salivary gland, fibrosis can be induced by irradiation treatment for cancer therapy, Sjögren’s Disease, other causes; however, it is unclear stromal cells signals participate in injury responses disease progression. As hedgehog signaling has been implicated of gland organs, we examined contributions effector, Gli1, to fibrotic glands. To experimentally...
Fibrosis results from excess extracellular matrix deposition, which alters normal tissue architecture and impedes function. Salivary gland fibrosis can be caused by irradiation therapy, as a treatment for head neck cancer, well the autoimmune disease Sjögren's Syndrome. The mechanisms that contribute to are complex poorly understood; however, defining cell types signaling pathways involved could reveal potential therapeutic targets. Stromal subpopulations have been shown fibrosis....