A5086583660- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Cardiovascular and exercise physiology
- Abdominal Trauma and Injuries
- Pelvic and Acetabular Injuries
- Nitric Oxide and Endothelin Effects
- Socioeconomic and Demographic Analysis
- Hernia repair and management
- Phosphodiesterase function and regulation
- Diabetes Management and Research
- Signaling Pathways in Disease
- Potassium and Related Disorders
- Blood properties and coagulation
- Intestinal and Peritoneal Adhesions
- Thyroid Disorders and Treatments
Universidade do Porto
2015-2024
San Antonio College
2024
Instituto Superior de Espinho
2021-2023
Hospital da Senhora da Oliveira Guimarães
2020-2022
Ruhr University Bochum
2013
Universidad de Navarra
2013
Background— Obesity and diabetes mellitus are important metabolic risk factors frequent comorbidities in heart failure with preserved ejection fraction. They contribute to myocardial diastolic dysfunction (DD) through collagen deposition or titin modification. The relative importance for DD of modification was investigated obese, diabetic ZSF1 rats after fraction development at 20 weeks. Methods Results— Four groups (Wistar-Kyoto, n=11; lean ZSF1, obese n=11, high-fat diet, n=11) were...
Inclusion of exercise testing in diagnostic guidelines for heart failure with preserved ejection fraction (HFpEF) has been advocated, but the target population, technical challenges, and underlying pathophysiological complexity raise difficulties to implementation. Hemodynamic stress tests may be feasible alternatives. Our aim was test Trendelenburg positioning, phenylephrine, dobutamine ZSF1 obese rat model find echocardiographic surrogates end-diastolic pressure (EDP) elevation HFpEF....
Myocardial stiffness and upward-shifted end-diastolic pressure-volume (P-V) relationship (EDPVR) are the key to high filling pressures in heart failure with preserved ejection fraction (HFpEF). Nevertheless, many patients may remain asymptomatic unless hemodynamic stress is imposed on myocardium. Whether delayed relaxation induced by pressure challenge contribute (EDP) remains unsettled. Our aim was assess effect of suddenly isovolumic afterload EDP, exploiting a highly controlled P-V...
Background: The interplay between the stiffened heart and vessels has long been viewed as a core mechanism in failure with preserved ejection fraction, but incremental vascular molecular remodeling mechanisms from systemic arterial hypertension to fraction remain poorly investigated. Our aim was characterize central dysfunction ZSF1 obese rats compare it hypertensive lean healthy Wistar-Kyoto controls. Methods Results: Twenty-week-old male (n=9), (n=9) underwent left ventricular...
Recent studies suggest right ventricular (RV) stiffness is important in pulmonary hypertension (PH) prognosis. Smaller stroke volume (SV) variation after a certain RV end-diastolic pressure (EDP) respiratory as assessed by spectral transfer function (STF) may identify stiffness. Our aim was to evaluate monocrotaline (MCT)-induced PH progression and validate STF gain between EDP SV marker of Seven-week-old male Wistar rats randomly injected with 60 mg/kg MCT or vehicle were divided into three...
The choice of inodilator drug in the acute management patients with pulmonary hypertension (PH) having right ventricular (RV) failure remains unsettled and challenging. Comprehensive experimental evaluations may provide further insight fundamental translational research clues to support selection clinical trial design. Our aim was compare dose-response hemodynamic effects inodilators dobutamine (DOB), milrinone (MIL), levosimendan (LEV) chronic PH. Seven-week-old male Wistar rats were...
Heart failure with preserved ejection fraction (HFpEF) is a syndrome characterized by impaired cardiovascular reserve in which therapeutic options are scarce. Our aim was to evaluate the inodilator levosimendan ZSF1 obese rat model of HFpEF. Twenty-week-old male Wistar-Kyoto (WKY), lean (ZSF1 Ln) and rats chronically treated for 6-weeks either (1 mg/kg/day, Ob + Levo) or vehicle Veh) underwent peak-effort testing, pressure-volume (PV) haemodynamic evaluation echocardiography (n = 7 each)....
Endothelin-1 antagonists are increasingly used in the treatment of pulmonary hypertension despite lack knowledge their myocardial and systemic effects. We assessed right ventricular effects endothelin-1 monocrotaline-induced hypertension. Male Wistar rats (180–200 g, n=57) randomly received 60 mg/kg monocrotaline or vehicle subcutaneously. Two days later, bosentan was started (300 mg/kg/day) by oral route a subgroup monocrotaline-injected rats, while other control vehicle. At 25–30 days,...
Diastolic dysfunction of the heart and decreased compliance vasculature lungs (i.e. increased organ tissue stiffness) are known features obesity metabolic syndrome. Similarly, cardiac diastolic is associated with aging. Elevation enzyme transglutaminase 2 (TG2) leads to protein cross-linking enhanced collagen synthesis participates as a candidate pathway for development stiffness. With these observations in mind we hypothesized that TG2 may be elevated tissues rat model obesity/metabolic...
Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with preserved ejection fraction (HFpEF), randomized clinical trials (RCTs) type-5 phosphodiesterase inhibitors (PDE5i) showed neutral results. Whether specific subgroups of HFpEF patients may benefit from PDE5i remains to be defined. Our aim test chronic sildenafil therapy the young male ZSF1 obese rat model severe hypertension and metabolic syndrome. Sixteen-week-old rats were...
Preserved ejection fraction heart failure (HFpEF) diagnosis remains controversial, and invasive left ventricular (LV) hemodynamic evaluation and/or exercise testing is advocated by many. The stiffer HFpEF myocardium may show impaired stroke volume (SV) variation induced fluctuating LV filling pressure during ventilation. Our aim was to investigate spectral transfer function (STF) gain from end-diastolic (EDP) indexed SV (SV i ) in experimental HFpEF. Eighteen-week-old Wistar-Kyoto (WKY) ZSF1...
The non-alcoholic fatty liver disease is the hepatic counterpart of metabolic syndrome. ZSF1 rats are a syndrome animal model in which changes have not been described yet.The characterization histological and innate immunity rats.Five groups were included (n = 7 each group): healthy Wistar-Kyoto control (Ctrl), hypertensive lean (Ln), obese with normal diet (Ob), rates high-fat (Ob-HFD), low-intensity exercise training (Ob-Ex). animals sacrificed at 20 weeks age, their livers collected for:...
Human umbilical cord matrix-mesenchymal stromal cells (hUCM-MSC) have demonstrated beneficial effects in experimental acute myocardial infarction (AMI). Reperfusion injury hampers recovery a clinical setting and its management is an unmet need. We investigated the efficacy of intracoronary (IC) delivery xenogeneic hUCM-MSC as reperfusion-adjuvant therapy translational model AMI swine.In placebo-controlled trial, pot-belied pigs were randomly assigned to sham-control group (vehicle-injection;...
Abdominal trauma is a major cause of morbi-mortality all over the world which makes it essential an approach focused on rapid diagnosis and treatment. The main goals this study are to identify global epidemiologic data abdominal in our tertiary center traumatic lesions, treatment outcome.Retrospective analysis clinical file patients admitted with trauma, period 5 years, center.the total mean ages was 42.6 years male gender most affected (74.2%). At admission, had Revised Trauma Score > 4....
Endothelin‐1 antagonists are increasingly used in the treatment of pulmonary hypertension despite lack knowledge their myocardial and systemic effects. We assessed right ventricular effects endothelin‐1 monocrotaline‐induced hypertension. Male Wistar rats (180–200 g, n=57) randomly received 60 mg/kg monocrotaline or vehicle subcutaneously. Two days later, bosentan was started (300 mg/kg/day) by oral route a subgroup monocrotaline‐injected rats, while other control vehicle. At 25–30 days,...
Introdução: A paralisia supranuclear progressiva (PSP) é uma doença neurodegenerativa, cuja prevalência de 2-7casos/100.000 indivíduos. No entanto, dado o desafio diagnóstico, prevê-se que estes dados estejam subestimados e muitos doentes não cheguem a ser diagnosticados. Descrição do caso: Mulher 69 anos, com hipertensão arterial hipotiroidismo controlados, recorreu em dezembro/2018 consulta aberta na sua USF por se sentir triste, choro fácil falta iniciativa associado episódios ansiedade....
Background: Low levels of triiodothyronine (T3) are common in patients with heart failure (HF). Our aim was to evaluate the effects supplementation low and replacement doses T3 an animal model HF preserved ejection fraction (HFpEF). Methods: We evaluated four groups: ZSF1 Lean (n = 8, Lean-Ctrl), Obese (rat metabolic-induced HFpEF, n 13, HFpEF), treated a dose HFpEF-T3high), low-dose HFpEF-T3low). administered drinking water from weeks 13 24. The animals underwent anthropometric metabolic...
New Findings What is the central question of this study? Right ventricle (RV) dysfunction highly prevalent in heart failure with preserved ejection fraction (HFpEF), nearly doubling risk death: what are RV functional and structural changes HFpEF how does aerobic exercise impact them? main finding its importance? The ZSF1 rat model presents mimicking human condition. Aerobic prevented decline , lowered surrogate markers overload (e.g., higher mean maximum systolic pressure) improved diastolic...
Introdução: Miíase é a infeção causada por larva de mosca, ocorrendo nas regiões (sub)tropicais. Nos países não-endémicos torna-se relevante, dado que os viajantes regressam podem importar infeções, expandindo transmissão destes agentes. A miíase furuncular mimetiza dermatoses comuns, podendo originar tratamentos inadequados. Pretende-se caracterizar as lesões, auxiliar no diagnóstico e tratamento, enfatizando importância anamnese adequada. Descrição do caso: Homem, 40 anos, sem antecedentes...
PURPOSE:To examine, in an animal model of heart failure with preserved ejection fraction (HFpEF), whether exercise training (ExT) would be able to improve capacity, diastolic function and exert anti-inflammatory effect. METHODS: The study involved nine-week old control Wistar-Kyoto rats (WKY, n=8), ZSF1 lean (Lean, n=8) obese (Ob n=16). At the 15th week, Ob were randomly divided sedentary (ObSED, exercised (ObEX, n=8; treadmill during 5 weeks, days/week, 60 min/day, at a speed 20m/min). In...
Introducao: A doenca soro-like e uma patologia rara, cuja fisiopatologia ainda nao se encontra estabelecida que ocorre mais frequentemente em idade pediatrica. O diagnostico essencialmente clinico, sendo determinado pela relacao temporal entre a ingestao do farmaco o aparecimento da sintomatologia (1-3 semanas), classicamente composta por febre, lesoes cutâneas artralgias. Geralmente estudo laboratorial plasmatico urinario apresentam alteracoes. Para seu devem ser excluidas outras...