A5017015119- Cellular Mechanics and Interactions
- Cancer, Lipids, and Metabolism
- Elasticity and Material Modeling
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Blood properties and coagulation
- Lipid metabolism and biosynthesis
- Force Microscopy Techniques and Applications
University of Glasgow
2018-2022
The increasingly recognised importance of viscoelastic properties cells in pathological conditions requires rapid development advanced cell microrheology technologies. Here, we present a novel Atomic Force Microscopy (AFM)-microrheology (AFM2) method for measuring the living cells, over wide range continuous frequencies (0.005 Hz ~ 200 Hz), from simple stress-relaxation nanoindentation. Experimental data were directly analysed without need pre-conceived models. We show had an excellent...
Article11 January 2022Open Access Source DataTransparent process THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer Arnaud Blomme Corresponding Author [email protected] orcid.org/0000-0003-4183-8726 CRUK Beatson Institute, Garscube Estate, Glasgow, UK Contribution: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing - original draft, Project administration, review & editing Search for more papers by this...
ABSTRACT Despite the clinical benefit of androgen-deprivation therapy (ADT), majority patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker ADT resistance in PCa. patients, THEM6 expression correlates progressive disease and is associated poor survival. deletion reduces vivo tumour growth restores castration sensitivity orthograft models CRPC. Mechanistically,...