A5100402644- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Carbohydrate Chemistry and Synthesis
- Supercapacitor Materials and Fabrication
- Advanced Battery Materials and Technologies
- Chemical Synthesis and Analysis
- Metallic Glasses and Amorphous Alloys
- Advancements in Battery Materials
- Pharmacological Receptor Mechanisms and Effects
- Peptidase Inhibition and Analysis
- Wheat and Barley Genetics and Pathology
- Photoreceptor and optogenetics research
- Nitric Oxide and Endothelin Effects
- Signaling Pathways in Disease
- Insect and Arachnid Ecology and Behavior
- Quasicrystal Structures and Properties
- Click Chemistry and Applications
- Plant Micronutrient Interactions and Effects
- bioluminescence and chemiluminescence research
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- Genetic and phenotypic traits in livestock
- Plant Disease Resistance and Genetics
- Neuroscience of respiration and sleep
- Lymphatic System and Diseases
Beihang University
2024
University of Pittsburgh
2024
University of Geneva
2024
Chinese Academy of Sciences
2004-2021
Shanghai Institute of Materia Medica
2011-2021
University of Chinese Academy of Sciences
2021
Zhejiang University
2019
Yangzhou University
2017
Beth Israel Deaconess Medical Center
2014
Harvard University
2014
Abstract 2D layered molybdenum disulfide (MoS 2 ) has garnered considerable attention as an attractive electrode material in sodium‐ion batteries (SIBs), but sluggish mass transfer kinetic and capacity fading make it suffer from inferior cycle capability. Herein, hierarchical MoS nanosheets decorated porous TiO nanofibers NSs@TiO NFs) with rich oxygen vacancies are engineered by microemulsion electrospinning method subsequent hydrothermal/heat treatment. The NFs improves ion/electron...
Abstract The human neuropeptide Y (NPY) 2 receptor (Y R) plays essential roles in food intake, bone formation and mood regulation, has been considered an important drug target for obesity anxiety. However, development of drugs targeting R remains challenging with no success clinical application yet. Here, we report the crystal structure bound to a selective antagonist JNJ-31020028 at 2.8 Å resolution. reveals molecular details ligand-binding mode R. Combined mutagenesis studies, provides...
The μ-opioid receptor (μOR), a prototypical G protein-coupled (GPCR), is the target of opioid analgesics such as morphine and fentanyl. Due to severe side effects current drugs, there considerable interest in developing novel modulators μOR function. Most GPCR ligands today are small molecules, however biologics, including antibodies nanobodies, represent alternative therapeutics with clear advantages affinity selectivity. Here, we describe nanobody NbE, which selectively binds acts an...
Abstract Background Signaling through vascular endothelial growth factor C (VEGF–C) and VEGF receptor 3 (VEGFR-3) plays a central role in lymphangiogenesis the metastasis of several cancers via lymphatics. Recently, Slit2/Robo4 pathway has been recognized as modulator permeability integrity. Robo inhibits VEGF-mediated effects; however, its effects on lymphatic cell function have not well characterized. Results We found that pretreatment with Slit2N, an active fragment Slit2, inhibited...
The greater wax moth, Galleria mellonella Linnaeus (Lepidoptera: Galleriinae), is a ubiquitous pest of the honeybee, and poses serious threat to global honeybee industry. G. pheromone system unusual compared other lepidopterans provides unique olfactory model for perception. To better understand mechanisms in mellonella, we conducted transcriptomic analysis on antennae both male female adults using high-throughput sequencing annotated gene families potentially involved chemoreception. We 46...
The cyclization reactions of arylamines with 2-deoxy-D-ribose or glycals were reinvestigated in the current report. In montmorillonite KSF- InCl(3)-initiated arylamines, a pair diastereomeric tetrahydro-2H-pyran-fused tetrahydroquinolines was obtained nearly 1:1 ratio where structure one diastereomer incorrectly assigned literature. Meanwhile, diastereoselectivity InBr(3)-catalyzed also reported previously. It found that high selectivity achieved only when C5-substituted glycal used;...
An unexpected N-glycosidation reaction of anthracen-1-amine with glycals was identified, and its use in the synthesis C1′ N-linked analogues natural product marmycin A explored. The structures all these products were determined by 1D 2D NMR, CD spectra, X-ray crystal analysis. These then subjected to Friedel–Crafts acylation, Dess–Martin oxidation nucleophilic addition leading novel bearing a quaternary carbon center.
Growth traits are important economic in broiler chicken production. AluI and Hin1I loci two restriction sites, which respectively located exons 2 3 of the IGF-1R gene. These significantly related to growth Jinghai Yellow chickens. In this study, a correlation analysis was performed between these Bian The results showed G376A mutation at site C919A site, resulted three genotypes AA, AB, BB exon CC, CD, DD 3. Correlation that female chickens with AA genotype locus had higher body weights than...
Our goal was to accurately track the cellular distribution of an optogenetic protein and evaluate its functionality within a specific cytoplasmic location. To achieve this, we co-transfected cells with nuclear-targeted cAMP sensors our laboratory-developed protein, bacterial photoactivatable adenylyl cyclase-nanoluciferase (bPAC-nLuc). bPAC-nLuc, when stimulated 445 nm light or luciferase substrates, generates adenosine 3',5'-cyclic monophosphate (cAMP). We employed solid-state laser...
Summary Cholecystokinin receptors, CCK A R and B R, are important neuro-intestinal peptide hormone receptors play a vital role in food intake appetite regulation. Here we report three crystal structures of the human complex with different ligands, including one agonist two small-molecule antagonists, as well cryo-electron microscopy R–gastrin G i2 q , respectively. These reveal recognition pattern ligand types molecular basis selectivity cholecystokinin receptor family. By comparing...