A5060076989- Pregnancy and preeclampsia studies
- Platelet Disorders and Treatments
- Cardiovascular Issues in Pregnancy
- Cancer, Hypoxia, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiovascular Health and Disease Prevention
- Erythropoietin and Anemia Treatment
- Maternal and fetal healthcare
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Reproductive System and Pregnancy
- Heparin-Induced Thrombocytopenia and Thrombosis
- Endometriosis Research and Treatment
- Autoimmune Bullous Skin Diseases
- Pregnancy-related medical research
- Fibroblast Growth Factor Research
- Genetic and phenotypic traits in livestock
- Lung Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Autoimmune and Inflammatory Disorders Research
- Reproductive Biology and Fertility
Takeda (United States)
2019-2024
Gunma University
2023
Baxalta (United States)
2019-2021
University of Vermont Medical Center
2016
University of Vermont
2005-2016
Moorfields Eye Hospital NHS Foundation Trust
2006
Good Samaritan Hospital
1996
Hypoxia inducible factor-1α (HIF-1α) stimulates expression of genes associated with angiogenesis and is poor outcomes in ovarian other cancers. In normoxia, HIF-1α ubiquitinated degraded through the E3 ubiquitin ligase, von Hippel-Lindau; however, little known about regulation hypoxic conditions. FBW7 an ligase that recognizes proteins phosphorylated by glycogen synthase kinase 3β (GSK3β) targets them for destruction. This study used cancer cell model to test hypothesis phosphorylation GSK3β...
Background Excessive or abnormal mucocutaneous bleeding (MCB) may impact all aspects of the physical and psychosocial wellbeing those who live with it (PWMCB). The evidence base for optimal diagnosis management disorders such as inherited platelet disorders, hereditary hemorrhagic telangiectasia (HHT), hypermobility spectrum (HSD), Ehlers-Danlos syndromes (EDS), von Willebrand disease (VWD) remains thin enormous potential targeted research.Research design methods National Hemophilia...
Recent findings indicate that endothelial nitric oxide (NO) plays a key role in uterine artery outward circumferential remodeling during pregnancy. Although the underlying mechanisms are not known, they likely involve matrix metalloproteinases (MMPs). The goal of this study was to examine linkage among NO inhibition, expansive remodeling, and MMP expression within vascular wall. Adult female rats were treated with N(G)-nitro-L-arginine methyl ester [L-NAME (LPLN)] beginning on day 10...
Objective: Indirect pharmacological evidence suggests that myocardial protection conferred by ischemic preconditioning in rabbit myocardium is mediated through the translocation of protein kinase C (PKC). To test this hypothesis, we performed direct biochemical measurements subcellular distribution PKC hearts. Methods: Two protocols were utilized. In Protocol I preconditioned group (PC) underwent two 5-min episodes brief coronary artery occlusion each followed 5 min reperfusion, while...
Von Willebrand disease (VWD) is the most common inherited bleeding disorder. The phenotype variable, and some individuals have persistent symptoms post-diagnosis.To characterize patterns in patients with VWD before after diagnosis.De-identified claims data for commercially insured IQVIA PharMetrics® Plus US database (Jan-2006 to Jun-2015) were extracted. Eligible had ≥2 (ICD-9 code 286.4), continuous health-plan enrolment years diagnosis. Bleeding event, treatment treating-physician type...
In vitro fertilization is a common method of in the case both humans and animals. Although this has developed very rapidly, there are still many unanswered questions about optimal characteristics that oocytes should have for performing procedure. The object study was to describe correlation between diameter size swine relation pubescence. research conducted on ovaries piglets (n = 65) adult 69). Each oocyte examined with without zona pellucida. analysis showed average from antral follicles...
Abstract Introduction Gastrointestinal (GI) bleeding events (BEs) in von Willebrand disease (VWD) are difficult to diagnose and often recurrent. Limited data from clinical trials has led lack of consensus on treatment options. Aim Describe current treatments outcomes for GI BEs people with VWD. Methods This retrospective, observational, multicentre chart review study was conducted January 2018 through December 2019 included patients inherited VWD ≥1 BE the preceding 5 years. Baseline...
Background Von Willebrand disease (VWD) is underdiagnosed, often delaying treatment. VWD claims coding limited, including no severity qualifiers; improved identification methods for are needed. This study's aim: identify and characterize undiagnosed symptomatic persons with in the US using medical insurance to develop predictive machine learning (ML) models.
Severe ADAMTS13 deficiency (activity <10%) is the diagnostic threshold for thrombotic thrombocytopenic purpura (TTP) and associated with various clinical symptoms, abnormal laboratory results, long-term complications.
Thrombotic thrombocytopenic purpura (TTP) is an ultra-rare blood disorder, characterized by severe ADAMTS13 deficiency. Affected individuals present with potentially life-threatening acute events and may experience sub-acute chronic TTP manifestations often resulting in long-term organ damage. Incremental symptom prevalence before, during, after event as well healthcare resource utilization (HCRU) costs during were compared between people matched non-TTP controls.
ADAMTS13 evolved to accommodate the hydrophobicity of its substrate.How active site contributes substrate recognition or protection from inhibitors is not known.Aims: Assess potential various chaotropic agents, organic solvents, and alcohols modulate activity.Methods: Full-length (10 nM) was incubated with increasing concentrations solvents for 5 minutes.The activity measured using 1 uM FRETS-VWF73 at pH 7.4.Additional experiments 10% ethanol were conducted MDTCS MD (100 7.4 FL-ADAMTS13...