OBJECTIVE: The prefrontal-parietal circuits have been reported to play an important role in working memory. purpose of this study was use direct neuroimaging address whether interregional correlation the is impaired schizophrenia. METHOD: [15O]H2O positron emission tomography used compare regional blood flow changes 12 schizophrenic and healthy comparison subjects during n-back sequential-picture memory task. Interregional assessed by correlating activation lateral prefrontal area with that...

Objective: The study was designed to elucidate regional brain metabolic changes according a treatment and their relationship with neuropsychological performance in obsessive–compulsive disorder (OCD). Method: Cerebral glucose rates were repeatedly measured before after 10 patients OCD using [ 18 F]‐2‐fluoro‐deoxyglucose positron emission tomography (PET). They compared on voxel‐basis, the correlations counted between degree improvement assessments. Results: After treatment, showed...

Given that obsessive-compulsive disorder (OCD) and schizophrenia may share clinical symptoms as well functional brain abnormalities, this study was designed to clarify common different morphological abnormalities in OCD schizophrenia.Volumes of the hippocampus, amygdala, thalamus were measured three age sex matched groups 22 patients with OCD, schizophrenia, normal subjects using dimensional magnetic resonance imaging. Volume tracing performed manually on serial coronal slices references...

Abstract We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high‐density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate characteristics mismatch negativity (MMN) generators in schizophrenia. LORETA, realistic head model boundary element derived from anatomy, estimated current density maps scalp topography 128‐channel EEG. From that covered whole cortical gray matter (up 20,000...

The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance the frontal-subcortical circuitry. To investigate morphological characteristics this circuitry, we examined volume orbitofrontal cortex, anterior cingulate, thalamus, caudate, and putamen in 36 age- sex-matched OCD patients normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. left volumes were found be significantly smaller showed significant negative correlations...

Past attempted suicide is a strong predictor of future risk, but the risk varies among attempters. Hence, it important to clarify distinguishing features lifetime attempters with high level current for efficient preventive management.We compared characteristics attempts and clinical high-, moderate-, low-risk Among total 6022 participants in Korean Epidemiologic Catchment Area study, 193 reported attempt their lifetime, 36 which had high, 126 moderate, 30 low levels (1 incomplete...

Abstract Background High doses of acetylcholinesterase (AChE) inhibitor Donepezil and non-competitive antagonist N-methyl-D-aspartate (NMDA) receptor Memantine are approved for the clinical treatment mild to severe Alzheimer's disease (AD). However, it is unclear which drug more appropriate when AD progresses from moderate-severe thus calls a neurobiological basis decisions. Aims & Objectives by viewing as disconnection syndrome, we explored brain connectivity biomarker medication choice...

This retrospective case series study of the effectiveness electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review.Clozapine-resistance defined as persistent psychotic symptoms despite at least 12 weeks clozapine administration with blood levels over 350 ng/mL in order to rule out pseudo-resistance. Seven in-patients who were taking and treated ECT selected. We analyzed psychopathology subscales changed ECT.The average number sessions 13.4...

Abstract Objective Mirtazapine is known to often provoke restless legs syndrome (RLS). In this retrospective chart review study, we evaluated the socio‐demographic and clinical factors related mirtazapine‐associated RLS. Methods Computerized medical records of 181 patients treated with mirtazapine from May 2004 October 2007 were reviewed. RLS was identified using diagnostic criteria International Study Group. Socio‐demographic characteristics gathered, including comorbid physical illness...

This study aimed to investigate the effectiveness and tolerability of combination electroconvulsive therapy (ECT) in patients with clozapine-treated schizophrenia.Patients schizophrenia during five years pre-determined period were recruited from Electronic Medical Record. Clinical effects acute ECT on psychotic symptoms investigated. We also tried identify predictive variables requiring maintenance treatment ECT.Fourteen received clozapine sixteen treated alone. In group, which could be...

Objective: The authors compared the neural circuits recruited for working memory (WM) in obsessive–compulsive disorder (OCD) patients both at a neutral state and symptom provoked state. Method: Twelve OCD patients, 12 age‐, sex‐matched healthy subjects underwent [ 15 O]H 2 O positron emission tomography (PET) scanning, while performing WM task. In tasks were performed states. Results: right caudate superior parietal cortex (rSPC) displayed activations state, cingulate rSPC Path analysis...

Aims: The aim of the present study was to examine how copy organization mediated immediate recall among patients with schizophrenia using Rey–Osterrieth Complex Figure Test (ROCF). Methods: Boston Qualitative Scoring System (BQSS) applied for qualitative and quantitative analyses ROCF performances. Subjects included 20 age‐ gender‐matched healthy controls. Results: During condition, group control differed in fragmentation; during two groups configural presence planning; delayed they several...