Michael J. Holmes

ORCID: 0000-0002-5270-1904
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About
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Research Areas
  • Marine Toxins and Detection Methods
  • Plant and animal studies
  • Insect and Arachnid Ecology and Behavior
  • Marine and coastal ecosystems
  • Insect and Pesticide Research
  • Building Energy and Comfort Optimization
  • Mercury impact and mitigation studies
  • Nerve injury and regeneration
  • Neuroscience of respiration and sleep
  • Protist diversity and phylogeny
  • Toxic Organic Pollutants Impact
  • Coal and Its By-products
  • Forest ecology and management
  • Neuroscience and Neural Engineering
  • BIM and Construction Integration
  • Marine Biology and Ecology Research
  • Pain Mechanisms and Treatments
  • Forest Management and Policy
  • Animal Ecology and Behavior Studies
  • Wind and Air Flow Studies
  • Animal Behavior and Reproduction
  • Nicotinic Acetylcholine Receptors Study
  • Muscle activation and electromyography studies
  • Rangeland and Wildlife Management
  • Cassava research and cyanide

The University of Sydney
2013-2024

Purdue University West Lafayette
2021-2024

The University of Queensland
1995-2023

South Australian Water Corporation
2005-2022

NSW Department of Planning and Environment
2022

Queensland Department of Environment and Science
2010-2021

Okinawa Institute of Science and Technology Graduate University
2018-2019

University of North Dakota
2004-2017

Iowa State University
2017

Bissell (United States)
2017

We have investigated the co-involvement of endogenous NGF and impulses in collateral sprouting cutaneous sensory nerves adult rats, specifically A delta-axons involved mechanonociception C-fibers that mediate heat nociception. Their was measured by progressive expansion, respectively, behaviorally defined "pinch" "heat" fields into surrounding denervated skin (the light-touch alpha-fibers do not sprout mammals). The expansions such "isolated" were totally prevented animals injected daily...

10.1523/jneurosci.12-04-01454.1992 article EN cc-by-nc-sa Journal of Neuroscience 1992-04-01

A key role has not yet been identified for beta nerve growth factor (NGF) in the responses that continue to be expressed sensory neurons of adult animals. We have now examined effects daily administration rats (and a few experiments, mice) antiserum NGF on (i) collateral sprouting undamaged nociceptive nerves occurs into denervated adjacent skin and (ii) regeneration cutaneous axons after they are damaged. The results were unexpected. All was prevented already progress halted; resumed when...

10.1073/pnas.84.18.6596 article EN Proceedings of the National Academy of Sciences 1987-09-01

Ciguatera is a type of food poisoning that results from eating certain tropical fish which have become toxic. It common in Australia: 175 outbreaks, involved 527 people, were reported Queensland between 1965 and 1984. seems restricted to areas around the Australian coastline. Most reports narrow-barred Spanish mackerel, Scomberomorus commersoni, most caught southern waters. Up 2100 cases may occurred north 1984, not recorded by writers. The symptoms ciguatera Australia are similar those...

10.5694/j.1326-5377.1986.tb139504.x article EN The Medical Journal of Australia 1986-12-01

ABSTRACT Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the growth of rodent malaria parasite Plasmodium berghei vivo. More than 90% asexual erythrocytic stages P. were inhibited after single intraperitoneal injection manzamine A into infected mice. remarkable aspect treatment is its ability to prolong survival highly parasitemic mice, with 40% recovery 60 days injection. Oral administration an oil suspension also produced significant reductions...

10.1128/aac.44.6.1645-1649.2000 article EN Antimicrobial Agents and Chemotherapy 2000-06-01

Litaker R.W., Vandersea M.W., Faust M.A., Kibler S.R., Chinain M., Holmes M.J., Holland W.C. and Tester P.A. 2009. Taxonomy of Gambierdiscus including four new species, caribaeus, carolinianus, carpenteri ruetzleri (Gonyaulacales, Dinophyceae). Phycologia 48: 344–390. DOI: 10.2216/07-15.1Gambierdiscus species produce toxins that cause ciguatera fish poisoning (CFP), the most common nonbacterial illness associated with consumption worldwide. Understanding role individual play in causing CFP...

10.2216/07-15.1 article EN Phycologia 2009-08-27

10.1016/j.marchem.2008.02.009 article EN Marine Chemistry 2008-03-05

Abstract Eusociality has convergently evolved multiple times, but the genomic basis of caste-based division labor and degree to which independent origins eusociality have utilized common genes remain largely unknown. Here we characterize caste-specific transcriptomic profiles across development adult body segments from pharaoh ants ( Monomorium pharaonis ) honey bees Apis mellifera ), representing two eusociality. We identify a substantial shared core upregulated in abdomens queen that also...

10.1038/s41467-019-10546-w article EN cc-by Nature Communications 2019-06-14

Ciguatera fish poisoning (CFP) is a serious health problem in tropical regions and caused by the bioaccumulation of lipophilic toxins produced dinoflagellates genus Gambierdiscus. Gambierdiscus species are morphologically similar difficult to distinguish from one another even when using scanning electron microscopy. Improved identification detection methods that sensitive rapid needed identify toxic investigate potential distribution abundance patterns relation incidences CFP. This study...

10.1111/j.1529-8817.2012.01146.x article EN Journal of Phycology 2012-03-20

A new, toxin‐producing, benthic dinoflagellate named Gambierdiscus yasumotoi sp. nov. was isolated from macroalgae the fringing coral reef surrounding Singapore island of Pulau Hantu. The plate formula G. is P o , 3′, 7", 6c, 6s, 5"′, and 2"". has a globular shape not anterior‐posteriorly compressed as are two other known species in this genus, toxicus Adachi et Fukuyo 1979 belizeanus Faust 1995. girdle descends one to widths without overhang contrast ascending girdles belizeanus. dimensions...

10.1046/j.1529-8817.1998.340661.x article EN Journal of Phycology 1998-08-01

Abstract Several competition indices are evaluated to determine their relationship with annual diameter growth in mixed species northern hardwood stands upper Michigan. Indices on four different shade tolerance. A new index which incorporates factors representing both root and crown is formulated tested. Simple size ratio perform as well or better correlation than growing space, area overlap, root/crown indices. Hegyi's several forms of the show most consistent performance across study...

10.1093/forestscience/37.5.1338 article EN Forest Science 1991-11-01

Abstract Three strains of cultured Gambierdiscus toxicus yielded distinct maitotoxins (maitotoxin‐1, ‐2, and ‐3) which were purified to homogeneity by high pressure liquid chromatography. Maitotoxins‐1 ‐2 are large toxins (molecular weights for the sodium salts = 3,422 3,298, respectively), whereas maito‐toxin‐3 is relatively small weight 1,060 salt). The contractile actions on isolated guinea‐pig left atria, vas deferens ilea maitotoxins‐1 compared with those maitotoxin, maitotoxin‐3....

10.1002/nt.2620020204 article EN Natural Toxins 1994-03-01

Abstract Coolia monotis is a benthic dinoflagellate previously thought to be non‐toxic. We describe new toxin, named cooliatoxin, purified from cultures of strain C. isolated Australia. Cooliatoxin likely mono‐sulphated, polyether toxin (Mr = 1,062; i.p. LD 50 1 mg/kg in mice) that induces hypothermia and respiratory failure mice after pronounced delay period during which there are no obvious signs intoxication. These similar those reported for the shellfish yessotoxin molecular weight...

10.1002/nt.2620030506 article EN Natural Toxins 1995-09-01

Abstract There have been many individual phytoplankton datasets collected across Australia since the mid 1900s, but most are unavailable to research community. We searched archives, contacted researchers, and scanned primary grey literature collate 3,621,847 records of marine species from Australian waters 1844 present. Many these small for local questions, combined they provide over 170 years data on communities in waters. Units taxonomy standardised, obviously erroneous removed, all...

10.1038/sdata.2016.43 article EN cc-by Scientific Data 2016-06-21
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