A5067582794- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Immune cells in cancer
- Tryptophan and brain disorders
- Bacteriophages and microbial interactions
- Prion Diseases and Protein Misfolding
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein purification and stability
- Protein Structure and Dynamics
- Nanoplatforms for cancer theranostics
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Cellular transport and secretion
- Brucella: diagnosis, epidemiology, treatment
- IL-33, ST2, and ILC Pathways
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Institute of Process Engineering
2023-2024
Tsinghua University
2014
Arizona State University
2003-2006
New York State Department of Health
2004
Wadsworth Center
2004
University at Albany, State University of New York
2004
George Washington University
2004
The University of Texas Health Science Center at Houston
2003
We examined the effects of co-incubating nine different Abeta peptide fragments with full-length Abeta1-40 (Abeta40) on protein aggregation. Six enhanced aggregation Abeta40 (Abeta1-28, 12-28, 17-28, 10-20, 25-35 and 17-40), while three others did not (Abeta1-11, 1-16, 20-29). All peptides that contained either residues 17-20 or 30-35, indicating importance these regions for promoting Abeta. Abeta25-35 in particular increased both rate extent considerably as indicated by fluorescence...
Abstract Immunotherapy has significantly improved cancer treatment, yet the immunosuppressive tumor microenvironment (TME) remains a substantial impediment to therapeutic efficacy. Nanomodulators have emerged as promising tools address factors within TME, enhancing clinical interventions such immunotherapy, chemotherapy, and radiotherapy while minimizing associated safety risks with immune modulators. In this review, recent advancements are spotlighted in TME‐targeted nanomodulators from...
β-Amyloid (Aβ) is a major pathological determinant of Alzheimer's disease (AD). Both active and passive immunization studies have shown that antibodies against Aβ are effective in decreasing cerebral levels, reducing accumulation, attenuating cognitive deficits animal models AD. However, the therapeutic potential these human AD patients limited because adverse inflammatory reactions hemorrhaging associated with treatments. Here we show single chain variable fragments (scFv's) represent an...
The α-synuclein protein has been strongly correlated with Parkinson's disease (PD) and is a major component of the hallmark Lewy body aggregates associated PD. Two different mutations in gene as well increased dosage wild-type all associate early onset cases PD; transgenic animal models overexpressing develop PD symptoms. α-Synuclein, natively unfolded protein, can adopt number folded conformations including β-sheet form that facilitates formation numerous aggregated morphologies, long...
Background Idiopathic pulmonary fibrosis (IPF) has attracted considerable attention worldwide and is challenging to diagnose. Cuproptosis a new form of cell death that seems be associated with various diseases. However, whether cuproptosis-related genes (CRGs) play role in regulating IPF disease unknown. This study aims analyze the effect CRGs on progression identify possible biomarkers. Methods Based GSE38958 dataset, we systematically evaluated differentially expressed immune...
Human tauopathies, including Alzheimer's disease (AD), are a major class of neurodegenerative diseases characterized by intracellular deposition pathological hyperphosphorylated forms Tau protein. Complement system is composed many proteins, which form complex regulatory network to modulate the immune activity in brain. Emerging studies have demonstrated critical role complement C3a receptor (C3aR) development tauopathy and AD. The underlying mechanisms C3aR activation mediates tau...
Deposition of beta-amyloid (Aβ) is considered an important early event in the pathogenesis Alzheimer's disease (AD). Clearance Aβ thus represents a potential therapeutic approach. Antibody-mediated clearance by vaccination inhibited and cleared deposition animal models; however, inflammatory side effects were observed humans. An alternative potentially noninflammatory approach to facilitate proteolytically cleave Aβ. We screened 12 proteolytic recombinant antibody fragments for α-secretase...
β-Amyloid (Aβ), a peptide generated by proteolytic cleavage of the amyloid precursor protein (APP), is major constituent neuritic plaques associated with Alzheimer's disease (AD). Up-regulation α-secretase, which can hydrolyze Aβ between Lys16 and Leu17, has been proposed as potential therapeutic strategy in treatment AD. Previously, we identified two light-chain antibody fragments that had activity against Aβ, one α-secretase-like carboxypeptidase-like activity. Here show Aβ40 hk14, having...
Brucellosis is a globally distributed zoonotic disease affecting animals and humans, current antibiotic vaccine strategies are not optimal. The surface-exposed protein Omp25 involved in Brucella virulence plays an important role pathogenesis during infection, suggesting that could be useful target for selecting potential therapeutic molecules to inhibit pathogenesis. In this study, we identified, believe the first time, peptides bind specifically of pathogens, using phage panning technique,...