A5024876432- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Ubiquitin and proteasome pathways
- Oral health in cancer treatment
- Stress Responses and Cortisol
- Medicinal Plants and Neuroprotection
- Biochemical Acid Research Studies
- Lysosomal Storage Disorders Research
- Nanoplatforms for cancer theranostics
- Bacterial Infections and Vaccines
- Fungal Infections and Studies
- Spinal Cord Injury Research
- Endoplasmic Reticulum Stress and Disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammasome and immune disorders
- Lipid Membrane Structure and Behavior
- Complement system in diseases
- Metabolism, Diabetes, and Cancer
Huazhong University of Science and Technology
2019-2024
Union Hospital
2019-2024
Henan Cancer Hospital
2019
Zhengzhou University
2019
Abstract Background Diabetes is associated with an increased risk of cognitive decline and dementia. These diseases are linked mitochondrial dysfunction, most likely as a consequence excessive formation mitochondria-associated membranes (MAMs). Sirtuin3 (SIRT3), key NAD + -dependent deacetylase, critical responsible for functional homeostasis highly neuropathology. However, the role SIRT3 in regulating MAM coupling remains unknown. Methods Streptozotocin-injected diabetic mice high...
Abstract Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression tauopathies. Irisin, muscle-derived hormone produced by proteolytic cleavage Fibronectin-domain III containing 5 (FNDC5), mediates pleiotropic effects exercise on physical body. Herein, we investigate potential role irisin in microglial senescence Methods To model tauopathies both vivo and vitro, utilized P301S tau transgenic mice K18 fibril-treated BV2 cells,...
This study aimed to identify the risk factors of candidemia and asses possible clinically significant differences between Candida parapsilosis other species in a Chinese tertiary cancer center over six years. A total 323 patients were enrolled analyzed from 2012 2018. Among isolates, most frequently isolated was C. (37.15%, 120/323), albicans only accounted for 34.37%. Based on statistical analysis, when who had compared with spp., following found be significantly associated fungemia:...
Metformin is a first-line anti-diabetic agent with powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and this effect independent its effect; however, specific mechanism remains unclear. In research, we explored in cerebral ischemia-reperfusion (I/R) injury by constructing transient middle artery occlusion model vivo glucose oxygen deprivation/reoxygenation (OGD/R) vitro. The results experiments showed acute treatment...
Human tauopathies, including Alzheimer's disease (AD), are a major class of neurodegenerative diseases characterized by intracellular deposition pathological hyperphosphorylated forms Tau protein. Complement system is composed many proteins, which form complex regulatory network to modulate the immune activity in brain. Emerging studies have demonstrated critical role complement C3a receptor (C3aR) development tauopathy and AD. The underlying mechanisms C3aR activation mediates tau...
Sepsis-associated encephalopathy is a common neurological complication of sepsis. Despite advances in pathological and diagnostic investigations, its treatment remains major challenge. In sepsis-associated encephalopathy, neuroinflammatory overactivation mitochondrial damage are thought to contribute cognitive behavioral impairments. this study, we found that administration (−)-Epicatechin, dietary flavonoid the flavan-3-ol subgroup, improves memory deficits behavior performance by...
Alzheimer’s disease (AD) is a destructive and burdensome neurodegenerative disease, one of the most common characteristics which are neurofibrillary tangles (NFTs) that composed abnormal tau protein. Animal studies have suggested dl-3-n-butylphthalide (dl-NBP) alleviates cognitive impairment in mouse models APP/PS1 SAMP8. However, underlying mechanisms related to this remain unclear. In study, we examined effects dl-NBP on learning memory P301S transgenic mice, carry human gene with...
Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of cognitive impairment. And the underlying mechanism remains unillustrated. HSPB8 a member small heat shock protein family. In this study, we found that expression was upregulated in hippocampus high - fat diet (HFD) + streptozotocin (STZ) induced diabetic mice and N2a cells exposed to glucose. Overexpression relieved decline DM mice. Mechanically, overexpression inhibited NOD-like receptor 3 (NLRP3) inflammasome activation...