A5050340792- Traumatic Brain Injury and Neurovascular Disturbances
- Mesenchymal stem cell research
- Thermal Regulation in Medicine
- Glioma Diagnosis and Treatment
- Hip and Femur Fractures
- Extracellular vesicles in disease
- Immune cells in cancer
- Anesthesia and Neurotoxicity Research
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- Traumatic Brain Injury Research
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Poisoning and overdose treatments
- Genomics and Phylogenetic Studies
- EEG and Brain-Computer Interfaces
- Microbial Community Ecology and Physiology
- Lysosomal Storage Disorders Research
- Dietary Effects on Health
- AI-based Problem Solving and Planning
- Bacteriophages and microbial interactions
- Neural dynamics and brain function
- Cutaneous Melanoma Detection and Management
- Human Motion and Animation
- Photoreceptor and optogenetics research
The University of Texas Southwestern Medical Center
2022-2025
Southwestern Medical Center
2023-2025
Duke University
2017-2022
Pratt Institute
2021-2022
Durham Technical Community College
2021
Aga Khan University
2014-2018
University at Buffalo, State University of New York
2018
Aga Khan University
2018
Aga Khan University Hospital
2016
Beth Israel Deaconess Medical Center
2012
Neural stem cells (NSCs) possess great potential for neural tissue repair after traumatic injuries to the central nervous system (CNS). However, poor survival and self-renewal of NSCs injury severely limits its therapeutic potential. Sulfated chondroitin sulfate glycosaminoglycans (CS-GAGs) linked CS proteoglycans (CSPGs) in brain extracellular matrix (ECM) have ability bind potentiate trophic factor efficacy, promote NSC vivo. In this study, we investigated CS-GAG hydrogels composed...
Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators inflammation, including macrophages and microglia, possess a range phenotypes relevant an immunomodulatory therapeutic approach. It is thought that early phenotypic modulation these cells will have cascading healing effect. fact, anti-inflammatory, "M2-like" macrophage phenotype TBI has been associated with neurogenesis,...
Introduction The apparent diffusion coefficient (ADC) sequence is based on the properties of water molecules within tissues and correlates with tissue cellularity. ADC may have a role in predicting tumor grade for gliomas, turn assist identifying biopsy sites. purpose this investigation was to assess competence preoperative values grades. Methods This retrospective investigation. We calculated areas greatest restriction solid components, we recorded pattern contrast enhancement. Pathology...
Background Data on the evaluation of Rotterdam Computed Tomography Classification (RCTS) as a predictor outcomes in patients undergoing decompressive craniectomy (DC) for trauma is limited and lacks clarity. Objective To explore role RCTS predicting unfavourable outcomes, including mortality DC head trauma. Methods This was an observational cohort study conducted from 1 January 2009 to 31 March 2013. CT scans adults with prior emergency were scored according RCTS. A receiver operating...
Patients with glioblastoma (GBM) have limited options and require novel approaches to treatment. Here, we studied deployed nonfreezing "cytostatic" hypothermia stunt GBM growth. This growth-halting method contrasts ablative, cryogenic that kills both neoplastic infiltrated healthy tissue. We investigated degrees of in vitro identified a cytostatic window 20° 25°C. For some lines, 18 hours/day was sufficient halt division vitro. Next, fabricated an experimental tool test local two rodent...
We present a case of congenital malignant melanoma the scalp in neonate. The child was born through caesarean section with swelling, size tennis ball, on posterior scalp. At presentation to clinic at 25 days after birth, swelling had significantly increased and ulcerated. An excision carried out but, because extensive haemorrhage haemodynamic instability, procedure limited subtotal resection. Later on, completion flap coverage wound were performed. After an initial stable course few months,...
To develop an implantable device capable of delivering intracranial cytostatic hypothermia in swine. Patients with glioblastoma (GBM) require novel approaches to treatment. We have previously demonstrated that intra-tumoral, non-freezing, 'cytostatic' hypothermia, can safely stunt GBM growth and effectively prolong survival rodents GBM. This was through a consisting thermoelectric cooler, probe, heat sink, fan. Unlike targeted therapeutics are successful preclinical models but fail clinical...
The treatment of glioblastoma (GBM) presents significant challenges, with median survival rates remaining low despite standard-of-care therapies. This study expands upon the findings a novel approach to managing GBM, namely cytostatic hypothermia, through computational evaluation fully implantable system. Our proposed system utilizes multi-probe array and artificial internal circulation (AICS) achieve homogeneous cooling within brain without overheating any portion body. Finite-element...
Abstract Survival rates for glioblastoma (GBM) patients are low due to the difficulty in eradicating all tumor cells, leading frequent recurrence. This recurrence is frequently within 2-cm from original site. Studies indicate that supra-total resection improves survival, and non-destructive local therapies show promise preventing GBM Our research demonstrates non-freezing, ‘cytostatic’ hypothermia effective against rats can be scaled pig models. method, unlike ablative cryogenic hypothermia,...
Abstract Novel therapeutic approaches are needed for patients with glioblastoma (GBM) who otherwise have limited options. Here we studied and deployed non-freezing ‘cytostatic’ hypothermia to stunt GBM growth. This contrasts ablative, cryogenic hypothermia: a double-edged sword against tumors infiltrating healthy tissue. We investigated three grades of in vitro identified cytostatic window 20–25°C. For some glioma lines, 18 h/d was sufficient halt division . Cytostatic induced cell cycle...
Abstract Chronic stimulation of and recording from the brain diseases can require expensive apparatus tedious cycles inducing rodents with anesthesia. To resolve this, we have designed fabricated a low-cost (∼$75 vs. $450) DIY rodent caging consisting commercially available 3D-printed components. This is customizable be used to rapidly prototype devices large sample sizes. Importantly, it enables continuous chronic brains awake freely moving rodents. It also opens possibilities trying...
Abstract Appropriately modulating inflammation after traumatic brain injury (TBI) may prevent disabilities for the millions of those inflicted annually. In TBI, cellular mediators inflammation, including macrophages and microglia, possess a range phenotypes relevant an immunomodulatory therapeutic approach. It is thought that early phenotypic modulation these cells will have cascading healing effect. fact, anti-inflammatory, “M2-like” macrophage phenotype TBI has been associated with...
Abstract Survival rates for patients with glioblastoma (GBM) remain discouraging due to the near-impossibility of eradicating all tumor cells, resulting in frequent recurrence. However, studies have shown that recurrence is predominantly localized (80% cases) and survival outcomes are improved supra-total resection. Consequently, non-destructive local therapies hold promise preventing GBM We demonstrated non-freezing, 'cytostatic' hypothermia a unique effective approach against GBM. Unlike...
Abstract As a cancer therapy, hypothermia has been used at sub-zero temperatures to cryosurgically ablate tumors. However, these can indiscriminately damage both tumorous and healthy cells. Additionally, strategies designed kill tumor typically accelerate their evolution recurrence be inevitable in cancers such as glioblastoma (GBM). To bypass limitations, here we studied the use of cytostatic tool against deployed it an aggressive rodent model GBM. identify minimal dosage ‘cytostatic...