Endothelial dysfunction and senescence are pivotal in pulmonary diseases, including chronic obstructive disease (COPD). Protein arginine methyltransferase 1 (PRMT1) is the major enzyme responsible for asymmetric dimethylation plays a role diverse biological processes, cardiovascular function. Yet, its endothelial cells (ECs) remains poorly understood. Here, of PRMT1 investigated ECs, particularly context COPD pathogenesis. Endothelial-specific knockout mice exhibit hemorrhage, inflammation,...

Prior knowledge facilitates our perception and goal-directed behaviors, particularly when sensory input is lacking or noisy. However, the neural mechanisms underlying improvement in sensorimotor behavior by prior expectations remain unknown. In this study, we examine activity middle temporal (MT) area of visual cortex while monkeys perform a smooth pursuit eye movement task with expectation target's motion direction. discriminately reduce MT responses depending on their preferred directions,...

The integration of sensory with top–down cognitive signals for generating appropriate sensory–motor behaviors is an important issue in understanding the brain's information processes. Recent studies have demonstrated that interplay between and high-level oculomotor behavior could be explained by Bayesian inference. Specifically, prior knowledge motion speed introduces a bias smooth-pursuit eye movements. other prediction inference variability reduction expectation; however, there...

Objectives
 To evaluate efficacy of the antenatal, intra-partum and post-natal antiretroviral components a public service Prevention Mother to Child (MTCT) program in infants. 
 Design
 Analysis prospectively collected screening data demographic MTCT-related interventions HIV-infection status infants identified through HIV-specific DNA polymerase chain reaction. Setting
 Tygerberg Children’s Hospital, Western Cape Province, South Africa. Subjects
 HIV-infected women...

Real-time PCR assays are valuable tools for the rapid and accurate diagnosis of infectious diseases by identifying nucleic acid sequences pathogens. Here, we aimed to develop a recombinant plasmid-based standard validating sensitivity different molecular diagnostic methods adopting Jonstrup assay (J assay). Chimeric plasmid DNA (cpDNA) harboring various pathogen genes target site J was constructed. Our findings revealed that could detect single copy gene similar digital droplet PCR. The...

When we interact with our environment, there is often a significant amount of variations in behavioral responses to incoming sensory input even when inputs are identical. Variations sensory-motor behavior can be caused by several factors, including changes cognitive status and intrinsic neural the brain. The correct identification sources important for understanding underlying mechanisms practical applications (e.g., development precise brain-computer interface). However, studies on humans...

Abstract Background: Inflammation is a key regulatory process in breast cancer progression and severity. Several studies have demonstrated that prolonged exposure of tumor cells to inflammatory cytokines leads epithelial-mesenchymal transitions (EMT), which the principle mechanism involved metastasis invasion. Disruption signaling pathways EMT may therefore provide an effective treatment strategy for currently difficult treat or untreatable cancers such as TNBC. The interleukin (IL)-1 plays...

To assess risk factors for loss to follow-up (LFU) from the IMPAACT P1041 study, an isoniazid (INH) prophylaxis study conducted in southern Africa.Infants two cohorts, human immunodeficiency virus-infected (HIV+) and HIV-exposed but non-infected (HIV-), were randomized INH or placebo 96 weeks. LFU was evaluated at week 96.Of 1351 infants, 12.9% (10.4% HIV+, 14.7% HIV-); 65% of HIV+ cohort asymptomatic. Among large household size (>6 vs. <4 members, P = 0.035) presence elder (≥55 years, 0.05)...

Psychophysiological insomnia (PI) patients have an excessive preoccupation with sleep and attentional bias towards sleep, which results in conditioning to pair sleep-related information autonomic arousal/emotional distress. However, there been limited researches on cognitive processes the PI. In present study, we compared task-related regional brain activity between PI good sleepers (GS) before after behavioral therapy for (CBTi), during traditional Color-Word Stroop Task (CWST) evaluating...

Abstract Prior knowledge facilitates our perception and goal-directed behaviors in the dynamic world, particularly when sensory input is lacking or noisy. However, neural mechanisms underlying improvement sensorimotor by prior expectations remain unknown. In this study, we examine activity middle temporal (MT) area of visual cortex while monkeys perform a smooth pursuit eye movement task with expectation target’s motion direction. discriminately reduce MT responses depending on their...

Abstract Background The proportion of young age-onset breast cancer in Korea is relatively higher than Western countries. Young patients are more likely to suffer from altered appearance due treatment such as disfiguration, hair loss, skin change and experience poor body image. This randomized controlled trial (RCT) designed evaluate the effect mind beauty education program on image among under 40-years old. Methods A total 109 eligible aged 18-40 years old, who had surgery and/or...

Abstract Humans integrate multiple sources of information for action-taking, using the reliability each source to allocate weight data. This reliability-weighted integration is a crucial property Bayesian inference. In this study, participants were asked perform smooth pursuit eye movement task in which we independently manipulated target motion and direction-of-motion cue. Through an analysis initiation multivariate electroencephalography activity, found neural behavioral evidence...

Abstract Background Glycated albumin (glycoalbumin, GA) is a biomarker that represents the glycemic status of short period. While Norudia GA assay kit (Sekisui Medical Co., Ltd., Tokyo, Japan) demonstrated performance comparative to Lucica GA-L (Asahi Kasei Pharma Corporation, Japan), we have experienced few cases with extremely low levels measured GA, inconsistent clinical status. Hence, evaluated analytical improved version claims solved false negative issue. Methods Precision and...

Abstract Purpose: Male breast cancer (MBC) is extremely rare, accounting for less than 1% of all malignancies in men and only carcinomas. The treatment surveillance guidelines on male cancers are recognized. aim this study to evaluate our single institution's experience with MBC over the past 15 years contrast differences between female MBC. Methods: diagnosed from 1994 2010 at Department Surgery, Samsung Medical Center (Seoul, Korea) was retrospectively analyzed. Clinical data tumor...

Abstract #2064 Background: EGF is a cytokine associated with cell proliferation, migration, and tumor invasion through EGFR activation in various cancer cells. activates its downstream molecules such as protein kinase C-δ, ERK, PI3-kinase, STAT-3. It has been shown that induces matrix metalloproteinase-9 (MMP-9), leading to migration of However, it not fully elucidated the roles STAT-1 STAT-3 breast We investigated regulatory mechanism on EGF-induced MMP-9 activity SKBR3 cells.&amp;#x2028;...

Insomnia has been characterized by state of hyperarousal. Patients with psychophysiological insomnia (PI) worry excessively about not being able to sleep. It disturbs relaxation and PI patients are less likely fall asleep. In current study, we aimed investigate intrinsic functional connectivity in PI, especially frontostriatal regions which is known as major nodes circuit associated arousal regulation. Thirteen (51.0 ± 10.2y, 10 females) 18 healthy good sleepers (42.7 12.3y, 14 underwent...