A5080978395- Advanced Chemical Sensor Technologies
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Mass Spectrometry Techniques and Applications
- Luminescence and Fluorescent Materials
- Molecular Junctions and Nanostructures
- Plasmonic and Surface Plasmon Research
- Gas Sensing Nanomaterials and Sensors
- Photonic and Optical Devices
- Air Quality Monitoring and Forecasting
- Molecular Sensors and Ion Detection
- Photonic Crystals and Applications
- Electrochemical sensors and biosensors
- Analytical Chemistry and Chromatography
- Water Quality Monitoring and Analysis
- Biosensors and Analytical Detection
- Lipid Membrane Structure and Behavior
- Advanced Fiber Optic Sensors
- Monoclonal and Polyclonal Antibodies Research
- Integrated Circuits and Semiconductor Failure Analysis
- VLSI and Analog Circuit Testing
- Engineering and Test Systems
- Acute Kidney Injury Research
Kyushu University
2016-2025
Kanazawa University
1998-2011
Sony (Japan)
2007
Sony (Taiwan)
2007
Japan Science and Technology Agency
2005
Hosei University
2002-2003
Waseda University
1993
A 2,6-dihydroxyterephthalic acid (2,6-DHTA)-treated taste sensor exhibited sensitivity and selectivity for umami substances, as previously reported. This study aims to investigate the relationship between sensor’s substance chemical structure of modifiers—specifically ortho, meta, para substituents. The investigations focused on using structurally different modifiers measure monosodium L-glutamate (MSG) at various concentrations. Additionally, based investigation lipid modifier conditions, a...
This study used an odor sensing system with a 16-channel electrochemical sensor array to measure beef odors, aiming distinguish odors under different storage days and processing temperatures for quality monitoring. Six ranged from purchase (D0) eight (D8), three temperature conditions: no heat (RT), boiling (100 °C), frying (180 °C). Gas chromatography-mass spectrometry (GC-MS) analysis showed that odorants in the varied conditions. Compounds like acetoin 1-hexanol changed significantly...
Polymerization of phenol with paraformaldehyde and catalytic sulfuric acid was carried out in room temperature ionic liquids based on imidazolium salts. The properties were systematically varied by employing six different anions such as chloride, bromide, iodide, tetrafluoroborate, trifluoromethanesulfonate hexafluorophosphate. In case hydrophilic having chloride or bromide anion, polymers low molecular weight narrow polydispersity obtained. contrast, using hydrophobic tetrafluoroborate...
Complementarity-determining regions (CDRs) are sites on the variable chains of antibodies responsible for binding to specific antigens. In this study, a short peptide probe recognition 2,4,6-trinitrotoluene (TNT), was identified by testing sequences derived from CDRs an anti-TNT monoclonal antibody. The major TNT-binding site in antibody heavy chain CDR3 antigen docking simulation and confirmed immunoassay using spot-synthesis based array comprising amino acid six region. A (RGYSSFIYWF)...
In this study, we developed a surface plasmon resonance (SPR) sensor chip based on 2,4,6-trinitrotoluene (TNT) recognition peptide-modified single-walled carbon nanotubes (SWCNTs). The carboxylic acid-functionalized SWCNTs were immobilized 3-aminopropyltriethoxysilane (APTES)-modified SPR Au surface. Through π-stacking between the aromatic amino acids and SWCNTs, TNT peptide TNTHCDR3 was onto of SWCNTs. peptide⁻SWCNTs-modified confirmed evaluated by atomic force microscope (AFM) observation....
The monitoring of salivary cortisol as a key biomarker an individual's stress response has been increasingly focused on. This paper describes the development novel immuno-assay method based on indirect competitive using commercially available surface plasmon resonance instrument. Au chip was modified with PEG6-COOH aromatic dialkanethiol self-assembled monolayers and hydrocortisone 3-(O-carboxymethyl) oxime (hydrocortisone 3-CMO) analog. A detection limit 38 ppt range measurement 10 ppt-100...
The use of taste sensors with lipid/polymer membranes is one the methods to evaluate taste. As previously reported, can detect non-charged substances such as caffeine by modifying hydroxybenzoic acids (HBAs). mechanism detection was identified be an allosteric one. Generally, mechanism, defined “regulation at distant sites”, used describe regulation process for proteins. In this study, improve sensitivity and its analogs using we various modifiers membranes, detected modified membranes....
In this study, a rationally-designed 2,4,6-trinitrotoluene (TNT) binding peptide derived from an amino acid sequence of the complementarity-determining region (CDR) anti-TNT monoclonal antibody was used for TNT detection based on maleimide-functionalized surface plasmon resonance (SPR) sensor. By antigen-docking simulation and screening, candidate peptides were obtained as TNTHCDR1 heavy chain CDR1, TNTHCDR2 CDR2, TNTHCDR3 CDR3 antibody. The events between evaluated using SPR sensor by...
In this paper, we develop a method of detecting 1,3,5-trinitroperhydro-1,3,5-triazine [research department explosive (RDX)]. RDX is one the main components plastic explosives. Initially, prepare an anti-RDX monoclonal antibody that specifically binds to RDX. The prepared from hybridoma cells are by iliac lymph node method. dissociation constant against estimated be 9.6 nM results indirect competitive enzyme-linked immunosorbent assay. We fabricate sensor chip on which analogues immobilized...
In this study, we modified a surface plasmon resonance immunosensor chip with polymer using surface-initiated atom transfer polymerization (SI-ATRP) for the highly sensitive detection of 2,4,6-trinitrotoluene (TNT). To immobilize TNT analogue on polymer, mono-2-(methacryloyloxy)ethylsuccinate (MES), which has carboxyl group, was used in study. However, anti-TNT antibody may adsorb non-specifically by an electrostatic interaction because MES is negatively charged. Therefore, mixed monomer and...
Inter-organismal communications below ground, such as plant-microbe interactions in the rhizosphere, affect plant growth. Metabolites are shown to play important roles biological communication, but there still remain a large number of metabolites soil be uncovered. Metabolomics, technique for comprehensive analysis samples, may uncover molecules that intermediate these interactions. We conducted multivariate using liquid chromatography (LC)-mass spectrometry (MS)-based untargeted...
We developed a chemical sensor based on hetero-core optical fiber structure where lipid films coat cylindrical cladding. Two lipids were applied to the surface: oleic acid and phosphoric di(2-ethylhexyl) ester. Experiments performed observe differential loss spectra over measured spectral region in response each substance. The acid- PAEE-coated sensors induced losses of approximately 0.4 0.2 dB, respectively, for refractive index difference 0.0008 between water quinine. Compared with...
By making use of the antigen-antibody interaction and a surface plasmon resonance (SPR) sensor, we developed measurement procedure displacement immunoassay to rapidly detect 2,4,6-trinitrotoluene (TNT).In this procedure, TNT solutions were injected in 30 s at end flowing an anti-TNT antibody.Three kinds sensor surfaces modified with analogues, namely, TNP-glycine, DNP-glycine, DNP-acetic acid self-assembled monolayer containing ethylene glycol.We investigated which analogues provided higher...
A taste sensor with lipid/polymer membranes can objectively evaluate taste. As previously reported, caffeine be detected electrically using modified hydroxybenzoic acids (HBAs). However, a systematic understanding of how HBAs contribute to detection is still lacking. In this study, we used various such as 2,6-dihydroxybenzoic acid (2,6-DHBA) modify membranes, and the membranes. The effect concentrations on was also discussed. results indicated that response reference potential measured in...
Nowadays, the utilization of a taste sensor with lipid/polymer membranes is one most accurate and objective ways to evaluate tastes solutions. However, it has been difficult uncharged sweet substances, such as sucrose, because conventional uses potentiometric measurement, which mainly based on changes in surface electric charge density membrane. Previous studies have reported that sweetness called GL1 can sugars sugar alcohols, commercially available for food, beverage, pharmaceutical...
In this paper, we describe the fabrication of novel poly(amidoamine) (PAMAM) dendron-based Surface Plasmon Resonance (SPR) sensor chip surfaces supported by a self-assembled monolayer (SAM) alkanethiol and their use in highly sensitive detection 2,4,6-trinitrotoluene (TNT), which is one main components explosives.The fabricated showed excellent binding capacity for TNT antibodies; probably due to fact that branched functional groups three-dimensional structure dendron molecules offer densely...