A5042214883- Neuroscience and Neuropharmacology Research
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Health and Medical Studies
- Neuroscience and Neural Engineering
- Air Quality and Health Impacts
- Anesthesia and Neurotoxicity Research
- Animal testing and alternatives
- Neural dynamics and brain function
- Electrochemical Analysis and Applications
- Ion channel regulation and function
- Insect and Pesticide Research
- Cholinesterase and Neurodegenerative Diseases
- Global Health Care Issues
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Medical and Health Sciences Research
- Environmental Toxicology and Ecotoxicology
- Heavy Metal Exposure and Toxicity
- Metabolomics and Mass Spectrometry Studies
- Neurological disorders and treatments
- Immunotoxicology and immune responses
- Retinoids in leukemia and cellular processes
Environmental Protection Agency
2014-2024
Research Triangle Park Foundation
2012-2023
Federal Ministry of Health
2020-2023
University of Cincinnati
2020
Medical University of South Carolina
2020
Cincinnati Children's Hospital Medical Center
2020
Brown University
2020
Greenwood Genetic Center
2020
University of Münster
2009-2016
German Council on Foreign Relations
2016
Polyhydramnios is defined as a pathological increase of amniotic fluid volume in pregnancy and associated with increased perinatal morbidity mortality. Common causes polyhydramnios include gestational diabetes, fetal anomalies disturbed swallowing fluid, infections other, rarer causes. The diagnosis obtained by ultrasound. prognosis depends on its cause severity. Typical symptoms maternal dyspnea, preterm labor, premature rupture membranes (PPROM), abnormal presentation, cord prolapse...
Gesundheits- und Sozialpolitik (G&S) , Seite 7 - 14
Developmental exposure of Long-Evans rats to 0, 1, 4, or 8 mg/kg/day Aroclor 1254 (A1254) from Gestational Day 6 through Postnatal 21 produces an elevated behavioral threshold for a 1-kHz tone. Brainstem auditory evoked responses (BAERs) were assessed in subset these animals (about 1 year old) using filtered clicks at (65 and 80 dB SPL), 4 (60 16 (40 32 SPL) kHz. decreased BAER amplitudes kHz, but not A dose-related decrease the baseline-to-peak P1A amplitude was observed (80-dB) stimulus....
Tris(2-chloroethyl)phosphate (TRCP), a flame-retardant plasticizer used in plastics, polymeric foams and synthetic fibers, was studied as part of the National Toxicology Program's class study phosphate flame-retardants. TRCP administered at 0, 22, 44, 88, 175 350 mg/kg to both sexes rats 175, 700 mice fourteen day repeat dose sixteen week subchronic studies. Results these studies showed that toxicity 14-day limited modest increases male rat kidney female liver weights. Little evidence...
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, minimally invasive methods detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, cerebrospinal fluid have great potential due the relative ease sampling but at present, data on their expression translation lacking or inconsistent. In this pilot study using trimethyl tin rat model central nervous system toxicity, we applied state-of-the-art...
Tris(2-chloroethyl) phosphate (TRCP), a flame retardant, produces dose-, sex-, and species-dependent lesion in the hippocampal region of brain following subchronic oral administration. This is more common severe female F344 rats than male rats, not observed B6C3F1 mice. The present investigation metabolism TRCP was designed to detect sex species variations that might account for differences toxicity. Elimination TRCP-derived radioactivity rapid mice, which excreted greater 70% an dose 175...
Cytokines, low-molecular-weight messenger proteins that act as intercellular immunomodulatory signals, have become a mainstream preclinical marker for assessing the systemic inflammatory response to external stressors. The challenge is quantitate from healthy subjects cytokine levels are below or at baseline and relate those dynamic complex signatures of exposures with repair pathways. Thus, highly sensitive, specific, precise analytical statistical methods critically important....