A5083609558- Anesthesia and Neurotoxicity Research
- Pesticide Exposure and Toxicity
- Signaling Pathways in Disease
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Radiation Therapy and Dosimetry
- Neurotransmitter Receptor Influence on Behavior
- Mass Spectrometry Techniques and Applications
- Toxic Organic Pollutants Impact
- Stress Responses and Cortisol
- Biochemical and Structural Characterization
- Cancer-related cognitive impairment studies
- Birth, Development, and Health
- Effects of Radiation Exposure
- Insect and Pesticide Research
- Neuroscience and Neural Engineering
- Environmental Toxicology and Ecotoxicology
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical Analysis and Applications
- Effects and risks of endocrine disrupting chemicals
- Brain Metastases and Treatment
- Nicotinic Acetylcholine Receptors Study
- PI3K/AKT/mTOR signaling in cancer
- Advanced Proteomics Techniques and Applications
Environmental Protection Agency
2021-2023
University of Cincinnati
2019-2023
Research Triangle Park Foundation
2021-2023
Cincinnati Children's Hospital Medical Center
2018-2022
University of Cincinnati Medical Center
2018-2022
University of Pittsburgh
2016
Pyrethroids are synthetic insecticides that act acutely on voltage gated sodium channels to prolong channel opening and depolarization. Epidemiological studies find exposure pyrethroids associated with neurological developmental abnormalities in children. The long-term effects of type II pyrethroids, such as deltamethrin (DLM), development have received little attention. We exposed Sprague-Dawley rats DLM by gavage at doses 0, 0.25, 0.5, 1.0 mg/kg/day from postnatal day (P) 3-20 a...
Journal Article Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses Get access Rachel L. Schassburger, MS, MS 1Center for Neuroscience, University of Pittsburgh , Pittsburgh, PA ; Search other works by this author on: Oxford Academic PubMed Google Scholar Emily M. Pitzer, BS, BS 2Department Dietrich School Arts and Sciences, Tracy T. Smith, PhD, PhD 3Department Psychology, Laura E. Rupprecht, Edda Thiels, 4Department Neurobiology, Medicine, Eric C. Donny, Alan F. Sved, &...
Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive decline compared with conventional (~1 Gy/s), but further preclinical data are required demonstrate this sparing effect. In study, postnatal day 11 (P11) rats were treated whole brain irradiation protons at a total 0, 5, or 8 Gy, comparing rate 1 Gy/s vs. FLASH 100 Gy/s. Beginning on P64, tested for locomotor activity, acoustic tactile...
Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate, amygdala, and cerebellum). Variants of associated ADHD. Null mutations Lphn3 in rat, mouse, zebrafish, Drosophila result hyperactivity, its role learning memory (L&M) largely unknown. Using our knockout (KO) rats we examined the cognitive abilities, long-term potentiation (LTP) CA1, NMDA receptor expression, neurohistology from heterozygous...
Pyrethroid pesticides are widely used and can cause long-term effects after early exposure. Epidemiological animal studies reveal associations between pyrethroid exposure altered cognition following prenatal and/or neonatal However, little is known about the cellular of such Sprague Dawley rats were gavaged with 0 or 1.0 mg/kg deltamethrin (DLM), a Type II pyrethroid, in corn oil (dose volume 5 mL/kg) once per day from postnatal (P) 3–20 assessed shortly dosing ended as adults. No DLM found...
Abstract Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse of proton radiotherapy, a model cognitive deficits from conventional exposure needed. We developed emphasizing multiple outcomes. Adult male rats (10/group) received single dose 0, 11, 14, 17, or 20 Gy irradiation (the group was used because 50% died). Rats were tested once/week for 5 weeks post-irradiation activity, coordination, and startle. Cognitive assessment began...
Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans exposed to PCB mixtures via contaminated food or water. exposure causes adverse effects in adults and after utero. toxicity depends on the congener mixture CYP1A2 gene activity. For coplanar PCBs, ligand affinity for aryl hydrocarbon receptor (AHR). Previously, we found that perinatal of mice a three-coplanar/five-noncoplanar induced deficits novel object recognition trial failures Morris water maze Cyp1a2-/- ::Ahrb1...
Label-free quantitation (LFQ) was applied to proteome profiling of rat brain cortical development during the early postnatal period. Male and female extracts were prepared using a convenient, detergent-free sample preparation technique at days (PND) 2, 8, 15, 22. The PND protein ratios calculated Proteome Discoverer, change profiles constructed separately for male animals key presynaptic, postsynaptic, adhesion proteins. compared analogous assembled from published mouse cortex proteomic...