Published on: January 2025 Indian Journal of Pharmacy Practice, 2025; 18(2):191-198. Original Article| doi: 10.5530/ijopp.20250118Authors and affiliation (s): Sudha Murthy*, Shekhar Yadav, Blessy George, Balakeshwa Ramaiah Department Karnataka College Pharmacy, Bangalore, Karnataka, INDIA. ABSTRACT Background: Type 2 Diabetes Mellitus, is an emerging complex metabolic disorder characterized by insulin resistance, impaired glucose uptake disrupted hepatic production. This study aimed to...

Background: Geriatric patients are individuals with compromised overall functioning. The objective of this study was to assess the prescribing pattern and evaluate therapeutic efficacy prescribed antibiotics. Methods: antibiotics were grouped using anatomical chemical classification (ATC) World Health Organization defined daily dose (WHO DDD)/100-bed days calculated analyse consumed neutrophils lymphocyte count before after therapy used efficacy. Results: Disease frequency categorised...

Background: Loop diuretics are essential for managing fluid overload in conditions like heart failure and chronic kidney disease. However, data on their utilization adverse outcomes resource-limited settings scarce. To evaluate patterns, drug reactions (ADRs), of loop diuretic therapy a tertiary care hospital. Methods: A prospective observational study was conducted 100 inpatients from January 2023 to October 2023. Data demographics, clinical indications, ADRs, prescription patterns were...

Background: Blood pressure (BP) variations and malnutrition are critical concerns in hemodialysis patients, significantly impacting morbidity, mortality quality of life. Accurate assessments using tools such as the Body Composition Monitor (BCM) can guide effective interventions to improve outcomes. This study aimed evaluate BP patients BCM, analysed dialysis-related complications assess impact targeted on patient Methods: A prospective observational was conducted 125 at a tertiary care...

Background: The rationale for starting AEDs in patients with seizure and early epilepsy is still unclear. decision to start stop the drugs single seizures remains controversial. This study aims compare efficacy, safety, short-term outcome of immediate, deferred, no use presenting seizure. Methods observational study, included 87 either gender or age group first multiple investigate AED use. Detailed demographics, history, diagnostic test reports were recorded. Drug patterns outcomes...

Background: Adverse drug reactions (ADRs) significantly contribute to global morbidity and mortality. Voluntary ADR reporting is crucial for the Pharmacovigilance Programme of India (PvPi), which identifies quantifies medication risks. This study monitors ADRs from various departments a tertiary care hospital, assessing them causality, preventability, severity before Indian Pharmacopoeia Commission (IPC). Methods: prospective was conducted over six months at an approved Monitoring Centre...

Background: Intravenous (IV) fluid therapy is a common and critical component in the emergency management of patients. However, inappropriate prescribing IV fluids can result adverse outcomes. Methods: This was prospective observational study involving 132 patients who received ED. The type fluids, indications, infusion rates demographic characteristics were recorded analyzed. Results: Out patients, 80 female 52 male. most frequently used Normal Saline (NS) (81%). primary indication for...

Background: Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are common comorbid conditions that pose significant management challenges due to drug-related problems (DRPs), which can adversely affect clinical outcomes. This study aimed evaluate the prevalence types of DRPs in T2DM HTN patients, analyse drug utilization patterns identify factors influencing DRPs. Methods: A prospective observational was conducted over six months at a multi-specialty hospital Bengaluru. Data from 110...

Background: Arrhythmias, particularly atrial fibrillation (AF), significantly contribute to morbidity and mortality, especially in older adults. Effective management is essential reducing stroke risk improving outcomes. However, real-world treatment often deviates from guidelines, raising concerns about care consistency. This study aims identify prevalent arrhythmias, assess risk, examine the relationship between arrhythmias age, analyze prescription patterns of antiarrhythmic drugs (AADs)...

The poor ocular bioavailability of the conventional eye drops is due to lack corneal permeability, nasolacrimal drainage and metabolic degradation. To overcome this issue, drug encapsulated in mucoadhesive polymer based microspheres have advantages improved stability, easy administration liquid form, diffuse rapidly better tissue internalization.The ganciclovir chitosan (GCM) were prepared by modified water-in-oil emulsification method. formulation was optimized characterized investigating...

Following administration, the antibiotic travels freely through body and also accumulates in other parts apart from infection site. High dosage repeated ingestion of antibiotics treatment pneumonia leads to undesirable effects inappropriate disposition drug. By way targeted lung delivery, this study was intended eliminate azithromycin achieve higher concentration treat deeper airway infections.The Azithromycin Albumin Microspheres (AAM) prepared by emulsion polymerization technique. The...

Background: Most developing countries are adopting antibiotic usage in sepsis. This study was conducted to evaluate the patients and medical adherence high-risk patients. The particular aims sepsis along with their related ADR’s. also optimize of antibiotics at a tertiary care hospital. Methods: Study prospective observational review record Clinical notes, medication chart electronic data management system hospital were used analyse antibiotics. Culture sensitivity reports obtained from...

Introduction: Chronic obstructive pulmonary disease (COPD) is a chronic of longer duration and generally progressive in nature.COPD needs treatment throughout the life.The main objective study to determine whether pharmacist intervention improves medication adherence COPD patients.Participants were enrolled after providing giving informed consent form.Methodology: A prospective interventional was conducted at SVS tertiary care hospital government Mahabubnagar getting ethical committee...

The objectives were to evaluate drug rash with eosinophilia and systemic symptoms syndrome due sulfasalazine carry out the pharmacoeconomic assessment associated this adverse reaction (ADR). A 37-year woman was presented rashes, fever, cough, dyspnea. In past 3 months, she on for inflammatory polyarthritis seronegative spondyloarthritis. diagnosis based raised eosinophils count, breathing difficulty, typical pattern of rashes. Significant improvement seen after discontinuation initiation...

Background: Heart rate is a key indicator of cardiovascular mortality, with ACS having the highest mortality risk when heart elevated. With target <70 bpm, it crucial to evaluate effects medications that lowers rate. Methods: In this prospective observational study, 45 patients were studied, and was determined whether or not patients' rates at discharge from hospital within goal range. Additionally, we looked demographics, drug-related issues, vitals then statistical tests performed....

Drug reaction with eosinophilia and systemic symptoms DRESS syndrome sometimes known as drug-induced hypersensitivity represents a unique potentially life-threatening adverse response triggered by medications. It typically presents skin rash resembling measles affecting individuals of various age groups accompanied like fever swollen lymph nodes irregular blood cell counts range multiorgan issues. Its incidence is 11000 to 10000 exposures its mortality 10-20. We report case patient diagnosed...

Published on: November 2024 Indian Journal of Pharmacy Practice, 2024; 18(1):92-98. Original Article| doi: 10.5530/ijopp.20250099Authors and affiliation (s): Shekhar Yadav*, Jeeva George, Balakeshwa RamaiahDepartment Karnataka College Pharmacy, Bangalore, Karnataka, INDIA. ABSTRACT Background: Cancer is a disease uncontrolled division cells in any part the body. Breast (BC) an emerging health issue among female population accounts for 13% death worldwide. The objective study was to evaluate...

Background: Shock, particularly septic shock, is a critical medical condition characterized by inadequate blood flow, leading to multi-organ failure and high mortality rates. Traditional treatment includes fluid resuscitation antibiotic therapy, but advancements in understanding management are needed. This study aims evaluate the rationale use of noradrenalin vasopressin patients with specifically focusing on their effects pressure. Methods: Conducted as prospective observational at tertiary...

Background: Anemia is a common prognosis of chronic kidney disease (CKD). It predominantly managed with erythropoietin and darbepoetin. The objective this study was to compare the efficacy safety injection versus darbepoetin for treating renal anemia amongst patient CKD. Methods: Patients either gender diagnosed due CKD, irrespective dialysis who had haemoglobin less than 12g/dl were included in study. Comparison done based on laboratory values hemoglobin (Hb), red blood cells (RBCs),...

Background: Cancer is the second leading cause of death worldwide. Chemotherapy a standard modality cancer treatment that uses chemical agents or drugs to destroy cells in cell cycles use chemicals inhibit cancerous growth and spread. The objective this study was assess IV compatibility chemotherapy drug different solution, frequency ADR, classify ADR according class dose adjustment. Methods: In study, patients either gender (aged 21-90) admitted on oncology department Bangalore Baptist...

Background: Antibiotics have significantly improved outcomes in surgical care, yet their overuse poses challenges such as antibiotic resistance and increased healthcare costs. Effective stewardship, particularly settings, is crucial for optimizing reducing resistance. This study aims to evaluate utilization patterns adherence prophylactic guidelines at a tertiary care hospital. Objectives: The primary objective was prospectively surgery Secondary objectives included assessing the prescribing...

Background: Our study aims to compare HbA1c levels in hospitalized acute coronary syndrome and heart failure patients treated with atorvastatin versus rosuvastatin Methods: This is a retrospective, prospective observational which the population includes ACS HF Hospitalized patients, subjects are divided based on prescribed Atorvastatin Rosuvastatin medication chart, those patients' previous history of statin use collected from patient case notes, doctors laboratory data documented collection...