A5101806449- Respiratory Support and Mechanisms
- Family and Patient Care in Intensive Care Units
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Statistical Methods in Clinical Trials
- Intensive Care Unit Cognitive Disorders
- Analytical Chemistry and Chromatography
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Computational Drug Discovery Methods
- Statistical Methods and Inference
- Respiratory and Cough-Related Research
- Colorectal Cancer Screening and Detection
- Cardiac Arrest and Resuscitation
- Antifungal resistance and susceptibility
- Nosocomial Infections in ICU
- Advanced Causal Inference Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- Chemistry and Chemical Engineering
- AI in cancer detection
Roche Pharma AG (Germany)
2021-2023
Technical University of Munich
2021-2023
Helmholtz Zentrum München
2021-2023
Roche (Switzerland)
2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2017
Instituto de Salud Carlos III
2017
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013-2017
MED Institute
2016
Universitat de Barcelona
2013
Hospital Clínic de Barcelona
2013
We assessed whether prolongation of nocturnal noninvasive ventilation (NIV) after recovery from acute hypercapnic respiratory failure (AHRF) in chronic obstructive pulmonary disease (COPD) patients with NIV could prevent subsequent relapse AHRF. A randomised controlled trial was performed 120 COPD without previous domiciliary ventilation, admitted for AHRF and treated NIV. When the episode resolved tolerated unassisted breathing 4 h, they were randomly allocated to receive three additional...
Introduction: Prognostic scores are important tools in oncology to facilitate clinical decision-making based on patient characteristics. To date, classic survival analysis using Cox proportional hazards regression has been employed the development of these prognostic scores. With advance analytical models, this study aimed determine if more complex machine-learning algorithms could outperform classical methods. Methods: In benchmarking study, two datasets were used develop and compare...
<b>Background:</b> Information on the best strategy for discontinuing non-invasive ventilation (NIV) after an episode of acute hypercapnic respiratory failure (AHRF) in patients with chronic obstructive pulmonary disease (COPD) or bronchitis is limited. Since these could develop hypoventilation during sleep, we assessed whether prolongation nocturnal recovery from AHRF NIV prevent subsequent relapse failure. <b>Methods:</b> A randomised controlled study was performed 120 COPD treated AHRF....
ChemPager is a freely available data analysis tool for analyzing, comparing and improving synthetic routes. Here, we present an expansion of this application that makes use the functionality PMI Predictor, which ACS Green Chemistry Institute Pharmaceutical Roundtable has recently published as web application. This addition enables to predict cumulative process mass intensity chemical routes, irrespective their development status, by comparison with set reactions executed on large scale. The...
Community-acquired pneumonia (CAP) is a major health problem with very high prevalence and mortality. Mortality can reach 13% among hospitalized patients nearly 50% in the long term (5 y). Similarly, acute coronary syndrome life-threatening condition for which clinical management has greatly improved because of effective protocols prehospital care evidence-based interventions hospital, within well-defined timescales. Unfortunately, CAP cannot be compared that terms risk stratification action...
External controls (eControls) leverage historical data to create non-randomized control arms. The lack of randomization can result in confounding between the experimental and eControl cohorts. To balance potentially variables cohorts, one proposed methods is match on prognostic scores. Still, performance scores construct eControls oncology has not been analyzed yet. Using an electronic health record-derived de-identified database, we constructed using three methods: ROPRO, a state-of-the-art...
Abstract Background The gold standard to evaluate treatment efficacy in oncology clinical trials is Overall Survival (OS). Its utility, however, limited by the need for long trial duration and large sample sizes. Thus methods such as Progression-Free (PFS) are applied obtain early OS estimates across phases, particularly decide on further development of new molecular entities. Especially cancer-immunotherapy, these established may be less suitable. Therefore, alternative approaches required....