Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase-responsive charge-reversal polymer mediates selective the cancer cells high esterases over fibroblasts low esterase activity. Its therapy with TRAIL suicide effectively induces apoptosis HeLa but does not activate to secrete WNT16B, enabling potent few side effects.

In light of current energy policies responding to rapid climate change, much attention has been directed developing feasible approaches for transitioning production from fossil-based resources renewable energy. Although existing studies analyze regional dispatch sources and capacity planning, they do not fully explore the impacts storage system technology's technical economic characteristics on integration transition, importance systems transition is currently ignored. To fill this gap, we...

In this paper, a distributed multi-objective optimization model is proposed to coordinate the fast-dispatch of photovoltaic (PV) inverters with slow-dispatch on-load tap changer and capacitor banks for implementing conservation voltage reduction in unbalanced three-phase distribution systems. existing studies, PV regulation devices are generally dispatched by fully centralized control frameworks. However, methods subject single point failure suffer large computational burden. To tackle these...

This article presents a supervised multi-agent safe policy learning (SMAS-PL) method for optimal power management of networked microgrids (MGs) in distribution systems. While unconstrained reinforcement (RL) algorithms are black-box decision models that could fail to satisfy grid operational constraints, our proposed considers AC flow equations and other limits. Accordingly, the training process employs gradient information constraints ensure control functions generate feasible decisions....

This paper proposes an asynchronous distributed leader-follower control method to achieve conservation voltage reduction (CVR) in three-phase unbalanced distribution systems by optimally scheduling smart inverters of energy resources (DERs). One feature the proposed is consider integrated primary-secondary networks and dependent loads. To ease computational complexity introduced large number secondary networks, we partition a system into zones based on network connectivity. address...

This paper proposes a service restoration model for unbalanced distribution systems and inverter-dominated microgrids (MGs), in which frequency dynamics constraints are developed to optimize the amount of load guarantee dynamic performance system response during process. After extreme events, damaged can be sectionalized into several isolated MGs restore critical loads tripped non-black start distributed generations (DGs) by black DGs. However, high penetration inverter-based DGs reduces...

This paper considers the co-operation of distributed generators (DGs), battery energy storage systems (BESSs) and voltage regulating devices for integrated peak shaving regulation in distribution grids through a co-optimization framework, which aims to minimize operational costs while fulfilling constraints network devices. To account uncertainties load demand generation, we then convert model into two-stage stochastic program where state-of-charge (SoC) trajectories BESSs operation are...

This paper proposes an online voltage control strategy of distributed energy resources (DERs), based on the projected Newton method (PNM), for unbalanced distribution networks. The optimal Volt/VAr (VVC) problem is formulated as optimization program, with goal maintaining profile across network by coordinating VAr outputs DERs. To overcome slow convergence rate conventional gradient-based methods, a PNM-based solution algorithm developed to solve this VVC problem. It utilizes non-diagonal...

This paper proposes a novel safety-critical secondary voltage control method based on explicit neural networks (NNs) for islanded microgrids (MGs) that can guarantee any state inside the desired safety bound even during transient. Firstly, an integrator is introduced in feedback loop to fully eliminate steady-state error caused by primary control. Then, considering impact of stability whole system, set transient and constraints developed. In order achieve online implementation requires fast...

This paper presents an approximate Reinforcement Learning (RL) methodology for bi-level power management of networked Microgrids (MG) in electric distribution systems. In practice, the cooperative agent can have limited or no knowledge MG asset behavior and detailed models behind Point Common Coupling (PCC). makes systems unobservable impedes conventional optimization solutions constrained problem. To tackle this challenge, we proposed a RL framework price-based environment. At higher level,...

Clinical development of 7-ethyl-10‑hydroxy-camptothecin (SN38), the active metabolite irinotecan (CPT-11), is hindered by its insolubility and poor stability. Another obstacle that tumors could become resistant to SN38/CPT-11 through multiple mechanisms involving breast cancer resistance protein (BCRP). Herein one most potent selective BCRP inhibitors, Ko143, encapsulated into a recently constructed prodrug PEG-S-S-SN38 displaying high fixed drug loading, intratumoral stimuli (oxidative...

This paper proposes a tractable distributionally robust chance-constrained conservation voltage reduction (DRCC-CVR) method with enriched data-based ambiguity set in unbalanced three-phase distribution systems. The increasing penetration of distributed renewable generation not only brings clean power but also challenges the regulation and energy-saving performance CVR by introducing high uncertainties to In most cases, conventional optimization methods for provide conservative solutions. To...

Recent years have seen the increasing proliferation of distributed energy resources with intermittent power outputs, posing new challenges to voltage management in distribution networks. To this end, paper proposes a data-driven affinely adjustable robust Volt/VAr control (AARVVC) scheme, which modulates smart inverter's reactive an affine function its active power, based on sensitivities respect real/reactive injections. achieve fast and accurate estimation sensitivities, we propose method...

Modification of drug delivery systems (DDSs) with stimuli-responsive elements could significantly increase the tumor-specific anticancer drugs. Herein we synthesized a novel multiple SN38 prodrug, named PEG-S-S-SN38, by conjugating PEG (MW: 2000) and disulfide bonds carbonic ester linkages as linkers for efficient SN38. The amphiphilic high loading content, self-assemble into nanoparticles (NPs) stable diameter ∼73 nm. PEG-S-S-SN38 NPs release very slowly at physiological pH, while they...

Doxorubicin (DOX) is a widely used chemotherapeutic drug to treat range of cancers. However, its unfavorable effects, particularly the cardiotoxicity and induction multidrug resistance (MDR), significantly limit clinical applications. Herein, novel doxorubicin prodrug, PEG2K -DOX, synthesized by conjugating deprotonated molecule with polyethylene glycol (PEG, MW: 2K) chain via pH-responsive hydrazone bond, potential as better alternative than evaluated. The data show that amphiphilic -DOX...

As the enthusiasm for electric vehicles passes range anxiety and other tests, large-scale transportation electrification becomes a prominent topic in research policy discussions. In consequence, public attention has shifted upstream holistically towards integration of to power systems. This paper proposes method identify bottlenecks transmission systems accommodate stochastic charging demands. First, distributionally robust chance-constrained direct current optimal flow model is developed...

High-rise buildings are everywhere with heavy electrical loads in metropolis, and their gravity potential energy can be utilized to develop mini-hydro pumped-storage scheme decrease many negative impacts on the power system, like large of load peak-valley difference (PVD), fluctuation as well integrated renewable distribution generation(DG). Shanghai Jinmao Tower 420.5 m high is taken a case study. China "Load Code for Design Building Structure" introduced roof tank design. time-of-use...

Abstract The enhanced permeability and retention (EPR) effect of tumors is much more complex than initially defined, it alone not sufficient for targeted delivery nanosized agents. Meanwhile, poor tumor penetration another major challenge the treatment solid using nanoparticles. Development systems SN38, active metabolite CPT‐11 in human a very potent anticancer molecule, has become an attractive research area. PEG x ‐p(HEMASN38) y (x are viable), prodrug synthesized by polyethylene glycol...

Substation ground system serves to safety of personnel and as major equipment during earth faults, which deserves considerable attentions. Basic substation assessment quantities include grid resistance, mesh touch potential step potential, moreover, optimal design should consider both safeness cost. To fill the lack such suitable economical software in North American industry, a package coded MATLAB is developed its core algorithm main features are introduced this paper. A novel hybrid GA-PS...

Electrical load is centralized in city, especial high-rise building which not only has PV generation resource but also a gravity potential. The height range of 30-400 meters, are everywhere city. Water necessary that city should have; water storage the roof, or body waist, and tank underground group, very difficult to build them, fact, system including pumping already been implemented those buildings for drink, sanitation, swim pool, fire control, drain, etc. hydro will added some new space,...