A5067810257- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Cancer-related cognitive impairment studies
- Brain Metastases and Treatment
- Nutrition, Genetics, and Disease
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Economic and Financial Impacts of Cancer
- Genomic variations and chromosomal abnormalities
- Cancer Risks and Factors
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Biosimilars and Bioanalytical Methods
Bank of Cyprus Oncology Center
2013-2024
Hammersmith Hospital
2004
Charing Cross Hospital
2004
St Bartholomew's Hospital
2000-2001
Objective Patients receiving chemotherapy often experience many different symptoms that can be difficult to alleviate and ultimately negatively influence their quality of life. Such include pain, fatigue, nausea, vomiting retching, anxiety depression. There is a gap in the relevant literature on effectiveness cognitive-behavioural relaxation techniques symptom clusters. The study reflects this aimed test Guided Imagery (GI) Progressive Muscle Relaxation (PMR) cluster experienced by patients...
Breast cancer is the most common form of malignancy affecting women worldwide. It also leading in females Cyprus, with approximately 400 new cases diagnosed annually. well recognized that genetic variation as environmental factors modulate breast risk. The main aim this study was to assess strength associations between risk and among Cypriot women. This first epidemiological investigation on female population.We carried out a case-control study, involving 1,109 patients group 1,177 controls...
In Cyprus, the prevalence of breast cancer associated with BRCA1 and BRCA2 mutations in young women is unknown. this study, we present results mutational analysis genes 26 Cypriot diagnosed by age 40. The entire coding regions, including splice sites, were sequenced using cycle sequencing. We identified four pathogenic mutations: two [c.1840A>T (K614X), c.5310delG (5429delG)] [c.3531-3534delCAGC (3758del4), c.8755delG (8984delG)] six unrelated patients. mutation c.3531-3534delCAGC (3758del4)...
Abstract Purpose: The EndoPredict prognostic assay is validated to predict distant recurrence and response chemotherapy primarily in post-menopausal women with estrogen receptor–positive (ER+), HER2− breast cancer. This study evaluated the performance of pre-menopausal women. Experimental Design: Tumor samples from 385 ER+, primary cancer (pT1-3, pN0-1) who did not receive addition endocrine therapy were tested produce a 12-gene EP molecular score an integrated EPclin that includes...
This paper presents the largest study in Cyprus evaluating frequency and distribution of BRCA1/2 mutations a high risk patient cohort. Deleterious genes were identified 68 527 patients tested (13%). It is interest that quarter those positive, did not have an extensive family history breast/ovarian cancer but diagnosed with early onset breast cancer, ovarian under age 60 or triple negative cancer. The spectrum our cohort different compared to other Mediterranean countries. Furthermore,...
Background: The Lapatinib Expanded Access Program (LEAP) was initiated in 45 countries to provide lapatinib combination with capecitabine patients ErbB2 (HER2)-positive breast cancer already treated anthracyclines, taxanes and trastuzumab. We report the results from 12 Central Eastern European countries. Patients Methods: By 30 September 2008, 293 were enrolled. monitored for serious adverse events (SAEs) any decrease left ventricular ejection fraction (LVEF). Overall survival...
In Cyprus, approximately 9% of triple-negative (estrogen receptor-negative, progesterone and human epidermal growth factor receptor 2-negative) breast cancer (TNBC) patients are positive for germline pathogenic variants (PVs) in BRCA1/2. However, the contribution other genes has not yet been determined. To this end, we aimed to investigate prevalence PVs BRCA1/2-negative TNBC unselected family history or age diagnosis. A comprehensive 94-cancer-gene panel was implemented 163 DNA samples,...
The PRS combines multiplicatively the effects of common low-risk single nucleotide polymorphisms (SNPs) and has potential to be used for estimation an individual's risk a trait or disease. been successfully implemented prediction breast cancer risk. combination with classical factors provides more comprehensive could, thus, improve stratification personalized preventative strategies. In this study, we assessed predictive performance combined effect PRS15 breast-cancer in Cypriot women using...
Lynch syndrome is the most common form of hereditary colorectal cancer and caused by germline mutations in mismatch repair (MMR) genes MLH1, MSH2, MSH6 PMS2. Mutation carriers have an increased lifetime risk developing as well other extracolonic tumours. The aim current study was to evaluate frequency distribution MSH2 within a cohort Cypriot families that fulfilled revised Bethesda guidelines. included 77 patients who at least one Mutational analysis revealed presence 4 pathogenic...
Abstract Breast cancer is a prevalent disease for women globally, with rising survival rates highlighting the need to address breast survivors’ (BCS) quality of Life (QoL). Furthermore, adherence healthy lifestyle associated decreased mortality in BCS. Mapping Lifestyle Medicine pillars and World Cancer Research Fund/American Institute recommendations identifies 7 components: weight management, physical activity, eating, restorative sleep, avoidance risky substances, positive social...
This article presents analyzed data on new diagnoses and mortality of breast cancer, between 2005 2013, in the Republic Cyprus. New are presented by demographic clinical/histological variables that include cancer grade, behaviour, stage, histological type at diagnosis (always as a primary site). Breast cancer-related deaths gender. Net survival rates based cohort period methods age group, stage diagnosis, for all cases Greek-Cypriot ethnicity. The unprocessed Cyprus Cancer Registry were...
This study is one of the first real-world cost-effectiveness analyses one-year adjuvant trastuzumab used in HER2-positive early female breast cancer comparison to chemotherapy alone. It just second Europe, Cyprus, and fourth worldwide ever carried out using data.