A5003886430- Genetic Neurodegenerative Diseases
- Nutritional Studies and Diet
- Climate Change and Health Impacts
- COVID-19 and healthcare impacts
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Nutrition, Genetics, and Disease
- Diet and metabolism studies
- Systemic Lupus Erythematosus Research
- Obesity, Physical Activity, Diet
- Neurological diseases and metabolism
- COVID-19 Pandemic Impacts
- Autoimmune and Inflammatory Disorders Research
- Bioinformatics and Genomic Networks
- COVID-19 and Mental Health
- Amyotrophic Lateral Sclerosis Research
- Rheumatoid Arthritis Research and Therapies
- Consumer Attitudes and Food Labeling
- Poisoning and overdose treatments
- Neurological disorders and treatments
University of Nicosia
2019-2025
Cyprus Institute of Neurology and Genetics
2014-2025
Imperial College London
2011-2015
Abstract Background This study aimed to investigate overall and sex-specific excess all-cause mortality since the inception of COVID-19 pandemic until August 2020 among 22 countries. Methods Countries reported weekly or monthly from January 2015 end June 2020. Weekly deaths were for Excess was calculated by comparing (observed deaths) against a baseline obtained 2015–2019 data same week month using two methods: (i) difference in observed rates between average (ii) expected deaths. Results...
Abstract Background The COVID-19 pandemic and the widespread adoption of virus control measures have inevitably disrupted efforts to address lifestyle risk factors for non-communicable diseases (NCD). This study aimed explore effects lockdown on all medicine pillars, namely diet, physical activity, sleep, stress, social support use risky substances. Methods was a cross-sectional convenient sample adults who resided in Cyprus during Spring 2020 lockdown. Participants completed an anonymous...
To examine the impact of COVID-19 pandemic on mortality, we estimated excess all-cause mortality in 24 countries for 2020 and 2021, overall stratified by sex age.
Diet has long been suspected to impact on breast cancer risk. In this study we evaluated whether the degree of adherence a Mediterranean diet pattern modifies risk amongst Greek-Cypriot women. Subjects included 935 cases and 817 controls, all participating in MASTOS case-control Cyprus. The was approved by Cyprus National Bioethics Committee. Information dietary intakes collected using an interviewer administered 32-item Food Frequency Questionnaire. demographic, anthropometric, lifestyle,...
Abstract Background Understanding the impact of burden COVID-19 is key to successfully navigating pandemic. As part a larger investigation on mortality impact, this study aims estimate Potential Years Life Lost (PYLL) in 17 countries and territories across world (Australia, Brazil, Cape Verde, Colombia, Cyprus, France, Georgia, Israel, Kazakhstan, Peru, Norway, England & Wales, Scotland, Slovenia, Sweden, Ukraine, United States [USA]). Methods Age- sex-specific death numbers from primary...
Abstract Background To understand the impact of COVID-19 pandemic on mortality, this study investigates overall, sex- and age-specific excess all-cause mortality in 20 countries, during 2020. Methods Total, weekly for 2015–2020 was collected from national vital statistics databases. Excess 2020 calculated by comparing observed against expected estimated historical data (2015–2019) accounting seasonality, long- short-term trends. Crude age-standardized rates were analysed total sex-specific...
ABSTRACT Healthy midlife cognitive function (CF) reduces the risk of later decline. Emerging evidence suggests that chrono‐nutrition may be associated with CF. This cross‐sectional cohort study aimed to examine associations between behaviours and CF in adults aged 45–65 years living Cyprus. Chrono‐nutrition, including misalignments actual preferred eating times, Mediterranean diet (MD) adherence, sleep physical activity were assessed using validated questionnaires. Computerised...
Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on case-control studies. Therefore, we prospectively assessed association between BC risk in postmenopausal women from Mediterranean cohorts within European Prospective Investigation into Cancer Nutrition. The analysis included 62,284 recruited Spain, Italy Greece who had complete dietary (collected...
Reproductive factors have been linked to both breast cancer and DNA methylation, suggesting methylation as an important mechanism by which reproductive impact on disease risk. However, few studies investigated the link between in humans. Genome-wide peripheral blood lymphocytes of 376 healthy women from prospective EPIC study was using LUminometric Methylation Assay (LUMA). Also, 458877 CpG sites additionally independent group 332 participants EPIC-Italy sub-cohort, Infinium HumanMethylation...
Coronavirus disease 2019 (COVID-19) has significantly affected the well-being of individuals worldwide. We herein describe epidemiology COVID-19 in Republic Cyprus during first epidemic wave (9 March–3 May 2020). analyzed surveillance data from laboratory-confirmed cases, including targeted testing and population screening. Statistical analyses included logistic regression. During period, 64,136 tests (7322.3 per 100,000) were performed, 873 cases diagnosed, 20 deaths reported (2.3%)....
Huntington’s disease is a rare neurodegenerative caused by cytosine–adenine–guanine (CAG) trinucleotide expansion in the Huntingtin (HTT) gene. Although (HD) well studied, pathophysiological mechanisms, genes and metabolites involved HD remain poorly understood. Systems bioinformatics can reveal synergistic relationships among different omics levels enables integration of biological data. It allows for overall understanding pathways, HD. The purpose this study was to identify differentially...
Abstract Background This study investigated cause-specific mortality rates in 12 countries during the COVID-19 pandemic 2020 and 2021. Methods We collected weekly data from respiratory disease, pneumonia, cardiovascular disease (CVD) cancer national vital statistic databases. calculated excess for (excluding codes), CVD 2021 by comparing observed against expected based on historical (2015–2019), accounting seasonal trends. used multilevel regression models to investigate association between...
Introduction: Parkinson's disease (PD) is a neurodegenerative disorder affecting substantial proportion of the elderly Cypriot population. The objective this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and find environmental factors are predictors for onset Methods: A case-control conducted with total 235 patients 464 healthy controls Greek-Cypriot ethnicity. Demographic lifestyle characteristics, exposure clinical...
Abstract Background: Infections from microorganisms and parasites have been connected with either increased or decreased cancer risk. The objective of this study was to investigate whether infection by Echinococcus granulosus is associated Methods: We assembled a pilot retrospective cohort patients who were diagnosed as being infected E. in Cyprus between 1930 2011. Age/gender-matched non-infected family members neighbors selected references. Medical history ascertained each subject through...