A5007021771- Clinical Nutrition and Gastroenterology
- Enhanced Recovery After Surgery
- Gut microbiota and health
- Nutrition and Health in Aging
- Diet and metabolism studies
- Streptococcal Infections and Treatments
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Alcoholism and Thiamine Deficiency
- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Diet, Metabolism, and Disease
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Otolaryngology and Infectious Diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infectious Diseases and Tuberculosis
- Human Health and Disease
- Pancreatic and Hepatic Oncology Research
Duke University
2023-2025
Duke Medical Center
2023
Duke University Hospital
2023
Johns Hopkins Medicine
2018
Johns Hopkins University
2018
Emory University
2014-2016
Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility infection; as such, state microbiome may have profound implications perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing analysis a mouse model general anesthesia investigate effects volatile anesthetics on diversity composition microbiome. After 4-hour exposure isoflurane, observed decrease bacterial diversity. Taxonomic alterations...
BACKGROUND: Previous work suggests that the gut microbiome can be disrupted by antibiotics, anesthetics, opiates, supplemental oxygen, or nutritional deprivation—all of which are common and potentially modifiable perioperative interventions nearly all patients exposed to in setting surgery. Gut microbial dysbiosis has been postulated a risk factor for poor surgical outcomes, but how care—independent intervention—impacts microbiome, potential consequences this impact have not directly...
Blood transfusion can be lifesaving for patients with hemorrhage; however, requirements victims of gun violence are poorly understood.In an urban, Level 1 trauma center, 23,422 were analyzed in a retrospective cohort study. Patients gunshot wounds (GSWs) (n = 2,672; 11.4% patients) compared to those non-GSW traumatic injuries from 2005 2017, assess blood utilization.The GSW was approximately five times more likely require (538 2672 [20.1%] vs. 798 20,750 [3.9%]; p < 0.0001), and the number...
Abstract CD8 T cell loss and dysfunction have been implicated in the increased susceptibility to opportunistic infections during later immunosuppressive phase of sepsis, but activation attrition early sepsis remain incompletely understood. With use a CLP model, we assessed at 5 consecutive time points found that after results distinct phenotype (CD69+CD25intCD62LHI) independent cognate antigen recognition TCR engagement likely through bystander-mediated cytokine effects. Additionally,...
<title>Abstract</title> Background Gut microbial dysbiosis in the intensive care unit (ICU) is common, and certain changes, such as expansion of <italic>Enterobacteriaceae</italic> other microbes with high pathogenic potential (pathobionts), are associated increased risk infection death. Enteral nutrition (EN) prebiotic short-chain fructooligosaccharides (scFOS-EN) promotes growth commensal like <italic>Bifidobacterium</italic> Firmicutes non-critically ill patients, thus may potentially...
Sepsis is the leading cause of death in intensive care units US, and it known that chronic alcohol use associated with higher incidence sepsis, longer ICU stays, mortality from sepsis. Both sepsis are immune deficits such as decreased lymphocyte numbers, impaired innate immunity, delayed-type hypersensitivity reactions, susceptibility to infections; however, understanding specific pathways interaction or synergy between these two states dysregulation lacking. This study therefore sought...
Iatrogenic aortic injury is a rare but potentially lethal complication of cardiac surgery. While sometimes resulting in dissection or intramural hematoma, more frequently results subadventitial benign pathology. Here, we describe case where intraoperative transesophageal echocardiography (TEE) identified such hematoma was unable to rule out dissection. Epiaortic ultrasound subsequently performed, which definitively demonstrated the absence flap extraluminal flow. Per our review, this first...
Margoles, Lindsay1; Mittal, Rohit1; Serbanescu, Mara1; Liang, Zhe1; Lyons, John1; Ford, Mandy1; Coopersmith, Craig2 Author Information