Enzymatically degradable polymeric micelles have great potential as drug delivery systems, allowing the selective release of their active cargo at site disease. Furthermore, enzymatic degradation nanocarriers facilitates clearance system after it has completed its task. While extensive research is dedicated toward design and study enzymatically hydrophobic block, there limited understanding on how hydrophilic shell micelle can affect properties such micelles. In this work, we report a...

The critical micelle concentration (CMC) is the key characterization of surfactants. To date, no method can yield sequential CMC measurements in an automated fashion. This work introduces SIMO (smart integrator for manual operations), a novel robotic platform automating determination It highlights precision and reproducibility SIMO, with 80% reduction standard deviation compared to method. article discusses protocol data postprocessing, highlighting challenges behind integrating automation...

Abstract The development of mechanically robust, chemically stable, and yet recyclable polymers represents an essential undertaking in the context advancing a circular economy for plastics. Here, we introduce novel cleavable β‐(1,3‐dioxane)ester ( DXE ) linkage, synthesized through catalyst‐free reaction β‐ketoester 1,3‐diol, to cross‐link poly(vinyl alcohol) PVA formation high‐performance thermosets with inherent chemical recyclability. , modified groups transesterification excess tert...

Enyzme-responsive polymeric assemblies hold great potential for biomedical applications due to the over-expression of disease-associated enzymes, which can be utilized activate such systems only in afflicted tissues. Herein we demonstrate that overall molecular weight amphiphiles, have same hydrophilic/hydrophobic ratio, tuned create micelles with an extreme range degradation rates. This approach expands available set parameters adjusted tune rate assemblies, paving new possibilities...

Functional composite materials that can change their spectral properties in response to external stimuli have a plethora of applications fields ranging from sensors biomedical imaging. One the most promising types used design spectrally active composites are fluorescent single-walled carbon nanotubes (SWCNTs), noncovalently functionalized by synthetic amphiphilic polymers. These coated SWCNTs exhibit modulations fluorescence spectra interactions with target analytes. Hence, identifying new...

The design of stable polymeric micelles that can respond to specific stimuli is crucial for the development smart micellar nanocarriers release their active cargo selectively at target site, thus diminishing therapeutic limitations due non-selective damage healthy tissues. Here we report and synthesis photo- enzyme-responsive amphiphilic PEG–dendron hybrids bearing one, two or four enzymatically cleavable azobenzene end-groups. These dual-responsive light through reversible isomerization...

Polymeric assemblies, such as micelles, are gaining increasing attention due to their ability serve nanoreactors for the execution of organic reactions in aqueous media. The conduct transformations, which have been traditionally limited media, water is essential further development important fields ranging from green catalysis bioorthogonal chemistry. Considering recent progress that has made expand range organometallic conducted using nanoreactors, we aimed gain a deeper understanding roles...

Enzyme-responsive polymeric micelles hold great potential as drug delivery systems due to the overexpression of disease-associated enzymes. To achieve selective and efficient their therapeutic cargo, need be highly stable yet disassemble when encountering activating enzyme at target site. However, increased micellar stability is accompanied by a drastic decrease in enzymatic degradability. The balance between degradation has severely limited applicability enzyme-responsive nanocarriers....

Stimuli-responsive polymers were synthesized by atom transfer radical polymerization (ATRP) using a photoresponsive self-immolative bifunctional initiator. The photoactivated junctions allow transforming nonresponsive into photocleavable that can be split two equally sized fragments when exposed to the stimulation. We demonstrate this modular approach preparing series of poly(benzyl methacrylate) and polystyrene various molecular weights. Taking advantage well-defined architecture polymers,...

Enzyme-responsive polymeric micelles have great potential as drug delivery systems due to the high selectivity and overexpression of disease-associated enzymes, which could be utilized trigger release active drugs only at target site. We previously demonstrated that enzymatic degradation rates amphiphilic PEG-dendron hybrids precisely tuned by gradually increasing hydrophobic hydrophilic ratio. However, with increase in hydrophobicity, rapidly became too stable not degraded, often...

Recovering monomers from the depolymerization of thermosets presents a significant challenge, which becomes even more daunting if one sets goal doing it directly, i.e., without complex chemical separation steps. To this end, we have synthesized new type polycarbonate thermoset by first copolymerizing alkyl cyclic carbonates (ACCs) with small amounts allyloxy (AoCCs), followed cross-linking resulting excess tetrathiol compounds under UV irradiation. These cross-linked polycarbonates...

Tuning the enzymatic degradation and disassembly rates of polymeric amphiphiles their assemblies is crucial for designing enzyme-responsive nanocarriers controlled drug delivery applications. The common methods to control amphiphilic polymers are tune molecular weights ratios hydrophilic hydrophobic blocks. In addition these approaches, architecture block can also serve as a tool disassembly. To gain deeper understanding effect block, we prepared two types well-defined PEG-dendron bearing...

Degradable polymeric micelles are promising drug delivery systems due to their hydrophobic core and responsive design. When applying micellar nanocarriers for tumor delivery, one of the bottlenecks encountered in vivo is tissue barrier: crossing dense mesh cells extracellular matrix (ECM). Sometimes overlooked, can trap nanoformulations based on charge, size, hydrophobicity. Here, we used a simple design microfluidic chip with two types ECM MCF7 spheroids allow "high-throughput" screening...

ABSTRACT Covalent surface modification of solid cellulose with well‐defined and chemically reactive dendrons is introduced as a platform for grafting functional materials. Surface functionalization first generation dendron achieved by esterification employing bifunctional molecules based on 2,2‐bis(hydroxymethyl) propionic acid (bis‐MPA) under mild conditions short reaction times. The activated displays hydrophobic properties contains two alkene end‐groups per graft, which are used covalent...

Taking advantage of the high fidelity thiol-ene and thiol-yne chemistries, we used mixtures thiols to prepare degradable PEG-dendron amphiphiles functionalized with two different types enzymatically cleavable end groups. By tuning feed ratios thiols, achieved hybrids statistically Studies disassembly mixed showed that these have higher degrees response when incubated each activating enzymes, whereas a greater degree selectivity was observed for control mixture distinct amphiphiles, which...

Abstract The development of mechanically robust, chemically stable, and yet recyclable polymers represents an essential undertaking in the context advancing a circular economy for plastics. Here, we introduce novel cleavable β‐(1,3‐dioxane)ester ( DXE ) linkage, synthesized through catalyst‐free reaction β‐ketoester 1,3‐diol, to cross‐link poly(vinyl alcohol) PVA formation high‐performance thermosets with inherent chemical recyclability. , modified groups transesterification excess tert...

Single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic polymers, find widespread applications including sensing and imaging. Identifying new amphiphiles with interchangeable building blocks that can form unique coronae around the SWCNT, customized for a specific application, is thus of great interest. We present polymer-dendron hybrids, composed hydrophobic dendrons hydrophilic polyethylene glycol (PEG), as amphiphilic macromolecules high degree structural...

ABSTRACT Degradable polymeric micelles are promising drug delivery systems due to their hydrophobic core and responsive design. When applying micellar nanocarriers for tumor delivery, one of the bottlenecks encountered in vivo is tissue barrier – crossing dense mesh cells extracellular matrix (ECM). Sometimes overlooked, can trap nanoformulations based on charge, size hydrophobicity. Here we used a simple design microfluidic chip with two types ECM MCF7 spheroids allow “high throughput”...

Functional composite materials that can change their spectral properties in response to external stimuli have a plethora of applications fields ranging from sensors biomedical imaging. One the most promising types used design spectrally active composites are fluorescent single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic amphiphilic polymers. These coated SWCNTS exhibit modulations fluorescence spectra interaction with target analytes. Hence, identifying new...

Polymeric assemblies, such as micelles, are gaining increasing attention due to their ability serve nanoreactors for the execution of organic reactions in aqueous media. The conduct transformations, which have been limited media, water is essential further development important fields greencatalysis and bioorthogonal chemistry, among other fields. In light recent progress expanding scopes that can be conducted using nanoreactors, we aimed gain deeper understanding roles hydrophobicity both...

Single-walled carbon nanotubes (SWCNTs), non-covalently functionalized by synthetic polymers, find widespread applications including sensing and imaging. Identifying new amphiphiles with interchangeable building blocks that can form unique coronae around the SWCNT, customized for a specific application, is thus of great interest. We present polymer-dendron hybrids, composed hydrophobic dendrons hydrophilic polyethylene glycol (PEG), as amphiphilic macromolecules high degree structural...

<p>Polymeric assemblies, such as micelles, are gaining increasing attention due to their ability serve nanoreactors for the execution of organic reactions in aqueous media. The conduct transformations, which have been limited media, water is essential further development important fields green</p><p>catalysis and bioorthogonal chemistry, among other fields. In light recent progress expanding scopes that can be conducted using nanoreactors, we aimed gain deeper understanding...