A5010978261- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Cell death mechanisms and regulation
- Neurotransmitter Receptor Influence on Behavior
- Neonatal and fetal brain pathology
- Connexins and lens biology
- Olfactory and Sensory Function Studies
- Cholinesterase and Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Free Radicals and Antioxidants
- Nitric Oxide and Endothelin Effects
Moscow Research and Clinical Center for Neuropsychiatry
2016-2025
Institute of Higher Nervous Activity and Neurophysiology
2016-2025
Research Center of Neurology
2016-2022
Pirogov Russian National Research Medical University
2017
Russian Academy of Sciences
2006-2015
Lomonosov Moscow State University
1985-2013
Academy of Medical Sciences
1993-2010
Saratov City Clinical Hospital № 2 named. IN AND. Razumovsky
2002
Purpose: To study brain-derived neurotrophic factor (BDNF) content in aqueous humor (AH), lacrimal fluid (LF), and blood serum (BS) patients with age-related cataract primary open-angle glaucoma (POAG).Methods: BDNF was studied 57 cataract, 55 POAG combined 29 healthy controls (one eye each person). AH sampled during surgery.Results: The levels of LF BS did not differ controls. concentration (pg/mL) lower than (35.2 ± 14.2 vs. 54.6 29.6, P < 0.001), (78.0 25.1 116.2 43.1, (19230 5960 22440...
Background: The hypothalamic-pituitary-adrenal (HPA) axis, inflammatory processes and neurotrophic factor systems are involved in pathogenesis of both epilepsy depressive disorders. study aimed to explore these patients with focal (PWE, n = 76), comorbid depression (PWCED 48), major disorder (PWMDD, 62) compared healthy controls (HC, 78). Methods: Parameters the HPA factors, TNF-α were measured blood serum along hemogram. Results: Serum cortisol level was augmented PWE, PWCED, PWMDD HC...
Traumatic brain injury (TBI) is one of the major causes severe neurological disorders and long-term dysfunction in nervous system. Besides inducing neurodegeneration, TBI alters stem cell activity neurogenesis within primary neurogenic niches. However, fate dividing cells other regions remains unclear despite offering potential targets for therapeutic intervention. Here, we investigated division differentiation non-neurogenic during acute delayed phases TBI-induced neurodegeneration. We...
Traumatic brain injury (TBI) is one of the primary causes mortality and disability, with arterial blood pressure being an important factor in clinical management TBI. Spontaneously hypertensive rats (SHRs), widely used as a model essential hypertension vascular dementia, demonstrate dysfunction hypothalamic–pituitary–adrenal axis, which may contribute to glucocorticoid-mediated hippocampal damage. The aim this study was assess acute post-TBI seizures, delayed mortality, pathology SHRs...
Abstract Slices from rat hippocampus were incubated with the caspase‐3 inhibitor N ‐benzyloxycarbonyl‐Asp‐Glu‐Val‐Asp fluoromethylketone (Z‐DEVD‐FMK) or inactive peptide ‐benzyloxycarbonyl‐Phe‐Ala (Z‐Phe‐Ala‐FMK) for 30 min. The peptides changed neither input–output curves nor paired‐pulse effects at 70‐msec interpulse intervals, amplitudes of pop spikes in CA1 region 1.0–6.9 hr after incubation. taken 1.0–1.4 Z‐DEVD‐FMK treatment demonstrated similar long‐term potentiation (LTP) curves;...