A5017086040- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
Institute of Higher Nervous Activity and Neurophysiology
2022-2025
Lomonosov Moscow State University
2022-2025
Traumatic brain injury (TBI) is one of the major causes severe neurological disorders and long-term dysfunction in nervous system. Besides inducing neurodegeneration, TBI alters stem cell activity neurogenesis within primary neurogenic niches. However, fate dividing cells other regions remains unclear despite offering potential targets for therapeutic intervention. Here, we investigated division differentiation non-neurogenic during acute delayed phases TBI-induced neurodegeneration. We...
Tagging proliferating cells with thymidine analogs is an indispensable research tool; however, the issue of potential in vivo cytotoxicity these compounds remains unresolved. Here, we address concerns by examining effects BrdU and EdU on adult hippocampal neurogenesis perinatal somatic development mice. We show that, a wide range doses, label similar numbers dentate gyrus shortly after administration. Furthermore, whereas administration does not affect division survival neural progenitor...