A5034170145- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Plant Pathogens and Fungal Diseases
- interferon and immune responses
- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Immune cells in cancer
- Oral microbiology and periodontitis research
- Viral gastroenteritis research and epidemiology
- Probiotics and Fermented Foods
- Gut microbiota and health
The Ohio State University
2019-2021
Michigan State University
2016-2017
Butyrate is an abundant metabolite produced by gut microbiota. While butyrate a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and the antiviral type I interferon (IFN) response have not been adequately investigated. We found increases cellular infection with viruses relevant to human animal health, including influenza virus, reovirus, HIV-1, metapneumovirus, vesicular stomatitis virus....
Infectious fungal species are often treated uniformly despite clear evidence of genotypic and phenotypic heterogeneity being widespread across strains. Identifying the genetic basis for this diversity is extremely challenging because tens or hundreds thousands variants that may distinguish two
Biofilms are organized communities of microbial cells that promote persistence among bacterial and fungal species. Biofilm formation by host-associated Candida species fungi occurs on both tissue surfaces implanted devices, contributing to host colonization disease. In C. albicans, biofilms built sequentially adherence yeast a surface, invasion into the substrate, aerial hyphal projections, secretion extracellular matrix. Measurement these biofilm-related phenotypes remains highly...
Abstract Butyrate is an abundant metabolite produced by the gut microbiota and known to modulate multiple immune system pathways inflammatory diseases. However, studies of its effects on virus infection cells are limited enigmatic. We found that butyrate increases cellular replication in influenza virus, reovirus, human immunodeficiency infections. Further exploring this phenomenon, we addition deficient type I interferon (IFN) signaling did not increase susceptibility infection....
Summary Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as acidic pH reactive oxygen species (ROS) during pathogenesis. The goal of this study was isolate compounds that inhibit resistance, thus defining virulence pathways are vulnerable chemotherapy. Here we report the pH-dependent compound AC2P36 depletes intracellular thiol pools, sensitizes Mtb killing by pH, potentiates bactericidal activity isoniazid, clofazimine, oxidizing agents. We show pHdependent is...
ABSTRACT The human commensal and opportunistic fungal pathogen Candida albicans displays extensive genetic phenotypic variation across clinical isolates. Here, we performed RNA sequencing on 21 well-characterized isolates to examine how contributes gene expression differences, link these differences traits. C. adapts primarily through clonal evolution yet hierarchical clustering of profiles in this set did not reproduce their phylogenetic relationship. Strikingly, strain-specific was...