A5101555725- Immunotherapy and Immune Responses
- interferon and immune responses
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Flavonoids in Medical Research
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Vectors
- Health Sciences Research and Education
- History of Medical Practice
- Atherosclerosis and Cardiovascular Diseases
- Radiology practices and education
- Dermatology and Skin Diseases
- Pregnancy and preeclampsia studies
- Natural product bioactivities and synthesis
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Epilepsy research and treatment
- Estrogen and related hormone effects
- Planetary Science and Exploration
- Urticaria and Related Conditions
- Neurological disorders and treatments
- Synthesis and biological activity
- Immune Response and Inflammation
- Advances in Oncology and Radiotherapy
- Inflammatory mediators and NSAID effects
GlaxoSmithKline (United States)
2018-2025
Drexel University
2017-2022
Institute for Molecular Medicine
2020
Renishaw (United Kingdom)
2019
Hammersmith Hospital
1983
Drugs targeting the ER-resident innate immune receptor Stimulator of Interferon Genes (STING) are in development for treatments cancer and inflammatory diseases. Accurate determination STING levels normal disease tissue is an essential component modeling pharmacology drug-target disposition. Using metabolic labeling with deuterium oxide paired high resolution mass spectrometry, we report protein fractional synthesis rates turnover wild-type (C57BL/6) inflamed mice carrying Trex1 D18N...
Abstract Flavonoids have a range of biological activities, including anti-inflammatory, anti-carcinogenic, and neuroprotective effects. Apigenin, one such flavonoid abundant in certain plants, has been employed for centuries the treatment Parkinson’s, neuralgia, asthma other diseases owing to positive health effects attributed this group compounds. Due Apigenin’s relative abundance low intrinsic toxicity amongst flavonoids, it can be considered as potential natural inflammatory disorders...
Abstract Apigenin, a natural flavonoid, found in several plants is known to have anti-oxidant and anti-inflammatory properties indicated by its use for centuries as medicinal approach treat inflammatory disorders. However, there are significant gaps knowledge regarding effect on dendritic cell (DC) function maintaining an immune balance immunospecialized locations like the central nervous system (CNS). In order establish potential utility of Apigenin therapeutic agent against...
Abstract BACKGROUND Failure of many brain tumor treatments has been attributed to the inability a compound cross blood-brain barrier. Convection-enhanced delivery (CED) offers method administer drugs directly site, thereby mitigating this limitation. CED used in several preclinical and clinical studies, though an approved treatment is yet come fruition. A medical device suitable for repeated intraparenchymal valuable strategies, but lack appropriate models capable infusing clinically...
Abstract Apigenin, a natural flavonoid, found in several plants is known to have anti-oxidant and anti-inflammatory properties indicated by its use for centuries as medicinal approach treat inflammatory disorders. However, there are significant gaps knowledge regarding effect on dendritic cell (DC) function maintaining an immune balance immunospecialized locations like the central nervous system (CNS). In order establish potential utility of Apigenin therapeutic agent against...