A5035429686- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Mass Spectrometry Techniques and Applications
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Spectroscopy and Chemometric Analyses
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Natural product bioactivities and synthesis
- Cavitation Phenomena in Pumps
- Advanced Chemical Physics Studies
- Higher Education and Teaching Methods
- Hydraulic and Pneumatic Systems
- Water Systems and Optimization
- Drug-Induced Hepatotoxicity and Protection
- Advanced Proteomics Techniques and Applications
- Plant Stress Responses and Tolerance
- Ginseng Biological Effects and Applications
- Bioinformatics and Genomic Networks
- Digital Marketing and Social Media
- Internet Traffic Analysis and Secure E-voting
- Metal and Thin Film Mechanics
- Network Security and Intrusion Detection
- Chemical Thermodynamics and Molecular Structure
Xiangtan University
2015-2024
Sichuan University
2007-2024
Shenyang Normal University
2024
West China Second University Hospital of Sichuan University
2022-2024
South China University of Technology
2009-2023
China Agricultural University
2012-2023
Huangshan University
2022
Xi'an Jiaotong University
2017-2021
State Council of the People's Republic of China
2021
Sichuan Agricultural University
2013-2018
The ion/ion reactions of several dozen reagent anions with triply protonated cations the model peptide KGAILKGAILR have been examined to evaluate predictions a Landau−Zener-based for likelihood electron transfer. Evidence transfer was provided by appearance fragment ions unique or capture dissociation. Proton and are competitive processes any combination anionic cationic reactants. For in peptides, proton is usually significantly more exothermic than If charge occurs at relatively long...
This study introduces an innovative contour detection algorithm, PeakCET, designed for rapid and efficient analysis of natural product image fingerprints using comprehensive two-dimensional gas chromatogram (GC × GC). method innovatively combines edge tracking with affinity propagation (AP) clustering peak in GC fingerprints, the first this field. Contour significantly reduces false positives caused by "burr" signals, while AP enhances accuracy face negatives. The efficacy approach is...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
The identification of interactions between drugs and target proteins plays a key role in genomic drug discovery. In the present study, quantitative binding affinities drug-target pairs are differentiated as measurement to define whether interacts with protein or not, then chemogenomics framework using an unbiased set general integrated features random forest (RF) is employed construct predictive model which can accurately classify pairs. predictability further investigated validated by...
An approach is described to increase the degree of protonation a polypeptide ion in gas phase. Sequential charge inversion reactions involving oppositely charged ions are used yield net charge. The illustrated here with conversion singly protonated bradykinin doubly bradykinin. first step involves peptide deprotonated via multiply anions derived from carboxylate-terminated dendrimers. Some was then converted cations amino-terminated overall illustrative general strategy for increasing...
Various reagent anions capable of converting polypeptide cations to via ion/ion reactions have been investigated. The major charge inversion reaction channels include multiple proton transfer and adduct formation. Dianions composed sulfonate groups as the negative carriers show essentially exclusive formation in protonated peptides proteins anions. carboxylate groups, on other hand, far more transfer, with degree dependent upon both size spacings between dianion. More highly charged...
Maize yield is limited by water deficit in the arid and semiarid regions of China. Conserving enhancing crop productivity are inevitable requirements for sustainable development efficient agriculture. Plant growth regulators (PGRs) play important roles maize stress tolerance. In this study, we investigated effect plant regulator-brazide, a functional analog brassinolide (BR), on resistance through two-year (2020–2021) field experiment. The experiment included four treatments (I100: 4012 m3...
Abstract Ions derived from negative electrospray ionization of polyamidoamine (PAMAM) dendrimer generation 0.5 were subjected to ion trap tandem mass spectrometry. Ion/ion proton transfer reactions used manipulate the charge states PAMAM precursor ions form lower those initially formed by electrospray, as well facilitate interpretation product spectra. Most products could be rationalized retro ‐Michael decomposition reactions. The dominant fragmentation channels are highly dependent on...
Protonated and deprotonated biological molecules in the gas phase play an important role life sciences research. The structural information accessible from ions is highly dependent upon their charge states. Therefore, it desirable to develop means for increasing absolute states, particularly ionization methods, such as MALDI, that yield relatively low ions. work presented here demonstrates formation of a doubly polypeptide or oligonucleotide ion (dianion) singly analogue via two sequential...
Retention indices for frequently reported compounds of plant essential oils on three different stationary phases were investigated. Multivariate linear regression, partial least squares, and support vector machine combined with a new variable selection approach called random‐frog recently proposed by our group, employed to model quantitative structure–retention relationships. Internal external validations performed ensure the stability predictive ability. All methods could obtain an...