A5077192003- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Fungal Biology and Applications
- Plant-Microbe Interactions and Immunity
- Microbial Metabolic Engineering and Bioproduction
- Plant and Fungal Interactions Research
- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Enzyme Catalysis and Immobilization
- Plant Disease Resistance and Genetics
- Mycobacterium research and diagnosis
- Metabolism, Diabetes, and Cancer
- Infectious Diseases and Mycology
- Bacterial biofilms and quorum sensing
Universidad de Murcia
2020-2025
Genetic regulation mechanisms rely on complex transcriptional networks that are often difficult to decipher. The study of transcription factor (TF) binding sites and their targets has traditionally faced scalability challenges, hindering comprehensive cistrome analyses. However, the development DNA affinity purification sequencing (DAP-seq) technique allowed unprecedented large-scale studies at genome-wide level TF with high reproducibility. In this study, we apply human opportunistic...
Mucor lusitanicus has emerged as a model organism for studying RNAi in early-diverging fungi. This fungus exhibits intricate pathways that play crucial roles regulating gene expression, destroying invasive exogenous genetic material, and controlling the movement of transposable elements (TEs) to ensure genome stability. One most fascinating this is non-canonical pathway (NCRIP), which independent Dicer Argonaute proteins uses atypical RNase III R3B2 degrade specific target messenger RNAs...
Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses significant threat to human health due its high mortality rate and recent association with SARS-CoV-2 infections. On the other hand, histone methylation is regulatory mechanism pleiotropic effects, including virulence of several pathogenic fungi. However, role epigenetic changes at level never has been studied in . Here, we dissected...
Mucorales are the causal agents for lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due mucoralean antifungal drug resistance and lack effective therapies. A concerning urgency among medical scientific community claims find targets development new treatments. Here, we reviewed different studies de-scribing role machinery a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its features independence Dicer Argonautes proteins....
Lipid accumulation in oleaginous organisms is initiated by AMP deaminase (AMPD) after nitrogen depletion because it mediates the concentration of intracellular adenosine monophosphate (AMP). However, role AMPD lipogenesis fungus Mucor circinelloides largely unknown. Therefore, we identified genes (ampd1 and ampd2) encoding investigated lipid synthesis this overexpressing deleting ampd genes. Deletion ampd1 ampd2 caused 21 28% increments contents under N-limited conditions, respectively....
AU : Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: Mucormycosis represents a group of infections with different organ manifestations caused by some species the fungal order Mucorales.Historically, this disease has received limited attention due to its low worldwide prevalence, but Coronavirus Disease 2019 (COVID-19) pandemic led an increase in incidence infections, including mucormycosis, raising concern about their risks [1,2].The prevalence mucormycosis increased up 50 times...
Abstract Mucorales are basal fungi that opportunistically cause a fatal infection known as mucormycosis (black fungus disease), which poses significant threat to human health due its high mortality rate and recent association with SARS-CoV-2 infections. On the other hand, histone methylation is regulatory mechanism pleiotropic effects, including virulence of several pathogenic organisms. However, role epigenetic changes at level never has been studied in Mucorales. Here, we dissected...