A5061554049- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Fungal Biology and Applications
- Aluminum toxicity and tolerance in plants and animals
- Mycobacterium research and diagnosis
- Radioactive element chemistry and processing
- Trace Elements in Health
- Geochemistry and Elemental Analysis
- Heavy metals in environment
- Legume Nitrogen Fixing Symbiosis
- Protist diversity and phylogeny
- Microbial Community Ecology and Physiology
- Plant-Microbe Interactions and Immunity
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Lysosomal Storage Disorders Research
- Animal Genetics and Reproduction
Universidad de Murcia
2021-2024
University of Pavia
2023
Universitat Rovira i Virgili
2019-2022
Institut d'Investigació Sanitària Pere Virgili
2019-2020
Abstract DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function lineages with high levels, such early-diverging fungi (EDF), is of particular interest. Here, we investigated the biological significance and evolutionary implications 6mA EDF, which exhibit divergent patterns usage. The analysis two Mucorales species displaying extreme usage reveals that levels show symmetric enriched highly expressed genes. In contrast, low...
Ibrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis.The aim of this study was to assess in vitro activity ibrexafungerp comparators against a collection 434 European blood isolates Candida.Ibrexafungerp, caspofungin, fluconazole, micafungin minimum inhibitory concentrations (MICs) were collected from 12 laboratories isolates, including 163 Candida albicans, 108 parapsilosis, 60 glabrata,...
Abstract Soil organisms exhibit high tolerance to heavy metals, probably acquired through evolutionary adaptation contaminated environments. Essentially, metal in fungi involves several specific and non-specific mechanisms that include efflux, binding cell walls, extracellular intracellular sequestration complexation with proteins. However, have adopted different strategies detoxify although species differ the used. In this complex molecular framework, metallothioneins (MTs) are becoming...
Abstract Mucorales are basal fungi that opportunistically cause a potentially fatal infection known as mucormycosis (black fungus disease), which poses significant threat to human health due its high mortality rate and recent association with SARS-CoV-2 infections. On the other hand, histone methylation is regulatory mechanism pleiotropic effects, including virulence of several pathogenic fungi. However, role epigenetic changes at level never has been studied in . Here, we dissected...
Cu is an essential trace element for cell growth and proliferation. However, excess of accumulation leads to cellular toxicity. Thus, precise tight regulation homeostasis processes, including transport, delivery, storage, detoxification, efflux machineries, required. Moreover, the maintenance critical survival virulence fungal pathogens. has been extensively studied in mammals, bacteria, yeast, but it not yet well documented filamentous fungi. In present work, we investigated tolerance...
Mucorales are the causal agents for lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due mucoralean antifungal drug resistance and lack effective therapies. A concerning urgency among medical scientific community claims find targets development new treatments. Here, we reviewed different studies de-scribing role machinery a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its features independence Dicer Argonautes proteins....
Abstract Mucorales are basal fungi that opportunistically cause a fatal infection known as mucormycosis (black fungus disease), which poses significant threat to human health due its high mortality rate and recent association with SARS-CoV-2 infections. On the other hand, histone methylation is regulatory mechanism pleiotropic effects, including virulence of several pathogenic organisms. However, role epigenetic changes at level never has been studied in Mucorales. Here, we dissected...
Mucopolysaccharidosis type I (MPSI) is a lysosomal storage disorder caused by loss of activity the enzyme |[alpha]|-L-iduronidase (IDUA), which responsible for catabolism glycosaminoglycans dermatan and heparan sulfate. The most severely manifested form disease Hurler syndrome, in death affects children first decade, due to respiratory failure cardiac disease.We recently reported correction metabolic, neurologic craniofacial manifestations MPSI murine model treated at birth intravenous...