A5004776477- Psoriasis: Treatment and Pathogenesis
- Health Systems, Economic Evaluations, Quality of Life
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Sexual function and dysfunction studies
- Hidradenitis Suppurativa and Treatments
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Colorectal and Anal Carcinomas
- Chemotherapy-related skin toxicity
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Anatomy and Medical Technology
- Therapeutic Uses of Natural Elements
- Surgical Simulation and Training
- Kidney Stones and Urolithiasis Treatments
- Sexuality, Behavior, and Technology
- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- Digital Imaging in Medicine
- LGBTQ Health, Identity, and Policy
- Pharmaceutical studies and practices
- Antifungal resistance and susceptibility
UCB Pharma (United States)
2022-2024
Duke Medical Center
2018-2023
UCB Pharma (Belgium)
2021-2022
Duke University
2018-2021
Duke University Hospital
2020
Madison Group (United States)
2018
Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterised by recurrent nodules, abscesses and draining tunnels, with patients often experiencing periodic worsening of symptoms, known as flares.1 Achieving control important to reduce flare frequency.1 Bimekizumab (BKZ) humanised monoclonal IgG1 antibody which selectively inhibits interleukin (IL)-17A F.2 We report the proportion who experienced at given visit cumulative remained flare-free up Weeks...
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that presents with painful nodules and abscesses, purulent drainage, scars. 1 • Prior biologic use may influence or be predictive of response to subsequent biologics in conditions skin, 2 but there lack research investigating this HS specifically.• BKZ, humanized IgG1 monoclonal antibody selectively inhibits interleukin (IL)-17F addition IL-17A, has demonstrated clinically meaningful improvements patients HS. 3,4 Here, we...
The NLRP3 inflammasome senses diabetic metabolites and initiates inflammation implicated in complications neurodegeneration. No studies have investigated bladder dysfunction (DBD), despite a high clinical prevalence. In vitro, we found that numerous activate primary urothelial cells. vivo, demonstrate is activated urothelia from genetic type 1 mouse (Akita) by week 15. We then bred an NLRP3−/− genotype into these mice this blocked cystometric markers of DBD. Analysis innervation established...
Single center studies have shown that positive UroVysion® fluorescence in situ hybridization results were associated with recurrence of nonmuscle invasive bladder cancer treated intravesical bacillus Calmette-Guérin. Our goal was to validate these findings.We performed a prospective, multicenter diagnostic trial determine whether the test could predict or progression patients primary high grade who scheduled receive Fluorescence testing prior first Calmette-Guérin instillation, sixth...
Constraints on surgical resident training (work-hour mandates, shorter programs, etc.) and availability of expert educators may limit the acquisition prosthetic skills. As a result, courses are being conducted to augment surgery learning experience.To evaluate impact hands-on cadaver-based teaching program procedural knowledge confidence with placement penile prosthesis.Changes in self-confidence following focused prosthetics.As part 2017 Society Urologic Prosthetic Surgeons Sexual Medicine...
Abstract Background Due to their location away from the nerve bundles, anterior prostate cancers (APC) represent a rational target for image-guided cryoablation. This report describes feasibility and short-term outcomes of focal cryosurgery. Methods A retrospective review between 2012 2016 patients with clinically localized APC treated gland cryoablation was performed. Descriptive statistics were used report: age, PSA, volume, cancer grade group (PGG), median time follow-up, changes in...
Introduction: A key factor of biologic discontinuation in plaque psoriasis patients is loss response over time; long-term treatment efficacy therefore important.1 Here, 3-year bimekizumab (BKZ) from a pooled analysis with moderate to severe across 3 phase clinical trials and their open-label extension (OLE) reported.
 Procedure/study: Data were the 52-week BE VIVID 56-week SURE READY trials, common OLE BRIGHT.2–5 Included received BKZ 320 mg every 4 weeks (Q4W) then switched Q4W or Q8W...
Abstract Introduction The preferred treatment for inflatable penile prosthesis (IPP) infection includes antibiotic therapy, device removal, and immediate replacement. While this is an accepted procedure, the delivery length of postoperative antibiotics are not standardized. Furthermore, historical salvage criteria may be overly restrictive given new techniques. Aim Our aim to determine if expanded shorter course demonstrate acceptable IPP rates. Methods We retrospectively reviewed 466...
Abstract Introduction Infection rates for virgin inflatable penile prostheses (IPPs) range from 1 to 3%; however, this can increase 7–18% after IPP revision or removal/replacement (RR) mechanical malfunction. Although studies have reported various RR and salvage cultures, limited data are available that directly compare microorganisms each of these procedures within the same patient. Comparison cultures may determine if infection is due a persistent microorganism new inoculation. Aim Our aim...
Emergency department visits after ureteroscopy are costly and inconvenient. To better understand those at risk we aimed to identify patient demographic, medical surgical factors associated with 30-day emergency presentation following for urolithiasis particular attention a history of psychiatric diagnosis.We retrospectively reviewed 1,576 cases (1,395 adults) who underwent stone related during 3 years total 2 hospitals. We collected demographics, operative details. The primary outcome was...
Lower urinary tract symptoms (LUTS) are an underrecognized complication of diabetes mellitus (DM) in adults and have undergone limited investigation children. We estimated the prevalence LUTS 120 older children (11-17 years) with without DM identified patient factors associated logistic regression. Older completed a validated measure questions about age, ethnicity, gender, body mass index, degree bother secondary to LUTS. The unadjusted was 20.87% overall cohort, twice as prevalent (33.3% vs...
Tables predicting the probability of a positive bone scan in men with non-metastatic, castrate-resistant prostate cancer have recently been reported. We performed an external validation study these positivity tables.
Introduction: Patients with moderate to severe plaque psoriasis have a higher risk of cardiometabolic comorbidities than the general population.1,2 Here, response bimekizumab (BKZ) in patients hypertension, elevated body mass index (BMI), or hyperglycemia at baseline is reported through 3 years treatment.
 Procedure/study: Data were pooled from following trials: BE SURE, VIVID, READY, their open-label extension (OLE) BRIGHT, and RADIANT.3–7 Included received BKZ 320 mg every 4 weeks...
Introduction: Psoriasis Area and Severity Index (PASI) is a commonly used tool for evaluating skin clearance; patients with ≥90% reduction from baseline PASI (PASI 90) have level of clearance that has been associated improved quality life.1 Bimekizumab (BKZ) monoclonal IgG1 antibody selectively inhibits interleukin (IL)-17F in addition to IL-17A.2 High 90 response rates observed BKZ, maintained through three years, across four phase 3/3b trials an open-label extension (OLE).3–7 Here, we...
Introduction: Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL‑17A.[1] Secukinumab (SEC) widely used targets IL-17A. BE RADIANT was the first phase 3 study compare inhibition of IL-17A and IL-17F with alone. Patient (pt) surveys have confirmed maintaining long-lasting response key treatment goal for patients who already achieved skin clearance.[2,3] Here, we assess efficacy BKZ vs SEC continuously an improvement ≥90% Psoriasis...