A5053244131- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Spinal Dysraphism and Malformations
- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Ureteral procedures and complications
- Pelvic floor disorders treatments
- Sexual Differentiation and Disorders
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Fetal and Pediatric Neurological Disorders
- Bladder and Urothelial Cancer Treatments
- Cerebrospinal fluid and hydrocephalus
- Congenital gastrointestinal and neural anomalies
- Hernia repair and management
- Testicular diseases and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal cell carcinoma treatment
- Prenatal Screening and Diagnostics
- Healthcare Policy and Management
- Genital Health and Disease
- Adolescent and Pediatric Healthcare
- Lysosomal Storage Disorders Research
Duke Medical Center
2016-2025
Duke University Hospital
2015-2025
Duke University
2011-2024
Duke Children's Hospital & Health Center
2023
La Jolla Alcohol Research
2021
GTx (United States)
2017
Vall d'Hebron Institut de Recerca
2016
Center for Special Minimally Invasive and Robotic Surgery
2016
St. Luke's Hospital
2016
Durham University
2010-2015
Care of children with spina bifida has significantly advanced in the last half century, resulting gains longevity and quality life for affected caregivers. Bladder dysfunction is norm patients may result infection, renal scarring chronic kidney disease. However, optimal urological management related bladder unknown.
Anecdotal evidence suggests that complex congenital genitourinary anomalies are occurring less frequently. However, few epidemiological studies available to confirm or refute this suggestion.The Kids' Inpatient Database (KID) is a national, all payer database of several million inpatient pediatric hospitalizations per year, including complicated and uncomplicated in-hospital births. We reviewed the 1997 2009 KID determine birth prevalence spina bifida, posterior urethral valves, bladder...
Abstract Human papillomaviruses (HPV), particularly types 16 and 18, may be carcinogenic effectors in a variety of human lower‐genital‐tract malignancies. Using the highly sensitive technique differential polymerase chain reaction (D‐PCR) with amplimers from E6 open reading frames HPV retrospective analysis 20‐year institutional experience squamous‐cell carcinoma penis (SCCP) was performed to determine prevalence these this malignancy. Paraffin‐embedded surgical specimens primary (N = 27),...
Hypospadias has no known single etiology but it been linked to androgen insensitivity caused by mutations of the receptor gene. The purpose this study was search for such in cases various degrees isolated hypospadias determine whether an association exists and, if so, with any particular anatomical subgroup.Isolated deoxyribonucleic acid from penile tissue 40 patients undergoing reconstructive surgery screened coding regions gene using strand conformational polymorphism analysis. In abnormal...
Primary vesicoureteral reflux (VUR) is the most common congenital anomaly of kidney and urinary tract, it a major risk factor for pyelonephritic scarring CKD in children. Although twin studies support heritability VUR, specific genetic causes remain elusive. We performed sequential genome-wide linkage study whole-exome sequencing family with hereditary VUR. obtained significant multipoint parametric logarithm odds score 3.3 on chromosome 6p, identified deleterious heterozygous mutation...
Most children with spina bifida now survive into adulthood, although most have neuropathic bladder potential complications of incontinence, infection, renal damage and diminished quality life. In this study we sought to 1) describe contemporary management continence outcomes adults bifida, 2) differences from younger individuals 3) assess for association socioeconomic factors.We analyzed data on in the National Spina Bifida Patient Registry. A strict definition was used. Results were...
Advances in care have allowed most children with spina bifida (SB) to live adulthood. The majority neuropathic bowel dysfunction (NBD), resulting constipation, incontinence, and diminished quality of life. We sought 1) describe contemporary NBD management continence outcomes adults SB; 2) differences from younger patients; 3) assess for association socio-economic factors.We analyzed data on the National Spina Bifida Patient Registry (NSBPR). Patients were segregated into young (5-11 years),...
Recent reports have suggested that caudal anesthesia may be associated with an increased risk of postoperative surgical complications. We examined our experience in hypospadias repair to evaluate for urethrocutaneous fistula or glanular dehiscence.All repairs performed by a single surgeon 2001-2014 were reviewed. Staged revision surgeries excluded. Patient age, weight, severity, surgery duration, month and year surgery, use, complications recorded. Bivariate multivariate statistical analyses...
Patients with spina bifida (SB) typically develop serious secondary conditions and undergo surgical procedures related to neurologic disorders, orthopedic abnormalities, bladder bowel dysfunction, skin breakdown. In this study, we describe the age distribution of common health outcomes in patients SB.Using serial cross-sectional data from National Spina Bifida Patient Registry (2009-2013; n = 4664), examined (gastrointestinal, neurologic, orthopedic, skin, urologic, other) (fecal continence,...
No AccessJournal of UrologyHypospadias1 Sep 1997Comparison Onlay and Tubularized Island Flaps Inner Preputial Skin for the Repair Proximal Hypospadias John S. Wiener, Richard W. Sutherland, David R. Roth, Edmond T. Jr. Gonzales WienerJohn Wiener , SutherlandRichard Sutherland RothDavid Roth GonzalesEdmond View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)64415-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked...
No AccessJournal of UrologyPEDIATRIC UROLOGY1 Sep 2000LONG-TERM EFFICACY OF SIMPLE BEHAVIORAL THERAPY FOR DAYTIME WETTING IN CHILDREN JOHN S. WIENER, MISCHCA T. SCALES, JASON HAMPTON, LOWELL R. KING, RICHARD SURWIT, and CHRISTOPHER L. EDWARDS WIENERJOHN WIENER More articles by this author , SCALESMISCHCA SCALES HAMPTONJASON HAMPTON KINGLOWELL KING SURWITRICHARD SURWIT EDWARDSCHRISTOPHER View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)67313-2AboutFull TextPDF ToolsAdd to...
In the last half century molecular biology, pathophysiology and natural history of sickle cell disease have been well defined. Sickle causes microvascular occlusion, which is manifested in most organ systems. The genitourinary tract commonly affected by hematuria, urinary infection priapism but other more serious sequelae identified.We performed a computerized MEDLINE search from 1965 to present bibliographic review cross references. These references were analyzed for meaningful findings...
ABSTRACT Neurogenic bladder predisposes to recurrent urinary tract infections (UTI) and renal failure, susceptibility is commonly ascribed stasis from elevated residual urine volumes. Escherichia coli UTI was modeled in the spinal cord-injured (SCI) rat with hypothesis that SCI animals would require fewer bacteria establish infection, have an exaggerated inflammatory response, delayed clearance of infection compared normal-voiding controls. T10 rats controls had median infectious doses (ID...
Urodynamic findings often guide treatment for neuropathic bladder and are reported as objective data points in multi-institutional trials. However, urodynamic interpretation can be variable. In a pilot study pediatric urologists interpreting videourodynamics exhibited only moderate agreement despite similar training practice patterns. We hypothesized the variability would replicated study.We developed an anonymous electronic survey that contained 20 scenarios, each with brief patient...
Nephron sparing surgery is the standard of care for many adults with renal tumors and has been described in some children Wilms tumor. However, beyond case series data concerning nephron application outcomes patients tumor are scarce. We examined factors associated its tumor.We retrospectively reviewed 1998 to 2010 SEER database. identified 18 years old or younger Clinical, demographic socioeconomic were abstracted, statistical analysis was performed using multivariate logistic regression...
No AccessJournal of UrologyTestis, Varicocele and Stones1 May 2015Estimating the Nationwide, Hospital Based Economic Impact Pediatric Urolithiasis Hsin-Hsiao S. Wang, John Wiener, Michael E. Lipkin, Charles D. Scales, Sherry Ross, Jonathan C. Routh WangHsin-Hsiao Wang , WienerJohn Wiener LipkinMichael Lipkin ScalesCharles Scales RossSherry Ross RouthJonathan View All Author Informationhttps://doi.org/10.1016/j.juro.2014.09.116AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...