A5056478559- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- Hernia repair and management
- Spinal Dysraphism and Malformations
- Tissue Engineering and Regenerative Medicine
- Carcinogens and Genotoxicity Assessment
- Congenital gastrointestinal and neural anomalies
- Hormonal Regulation and Hypertension
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Renal and related cancers
- Kidney Stones and Urolithiasis Treatments
- Urinary Tract Infections Management
- Urinary and Genital Oncology Studies
- Pelvic floor disorders treatments
- Renin-Angiotensin System Studies
- Cerebrospinal fluid and hydrocephalus
- Urologic and reproductive health conditions
- Birth, Development, and Health
- Air Quality and Health Impacts
- Pregnancy and preeclampsia studies
Monroe Carell Jr. Children's Hospital
2012-2024
University of North Carolina at Asheville
2016-2023
Vanderbilt University Medical Center
2011-2022
Vanderbilt University
2004-2021
John Wiley & Sons (United Kingdom)
2019
Hudson Institute
2019
Nashville Oncology Associates
2011-2018
Children's Hospital of Pittsburgh
2016
Warren Wilson College
2005-2015
Centers for Disease Control and Prevention
2002-2015
Prenatal repair of myelomeningocele, the most common form spina bifida, may result in better neurologic function than deferred until after delivery. We compared outcomes utero with standard postnatal repair.We randomly assigned eligible women to undergo either prenatal surgery before 26 weeks gestation or repair. One primary outcome was a composite fetal neonatal death need for placement cerebrospinal fluid shunt by age 12 months. Another at 30 months mental development and motor...
We measured the urinary monoester metabolites of seven commonly used phthalates in approximately 2,540 samples collected from participants National Health and Nutrition Examination Survey (NHANES), 1999-2000, who were greater than or equal to 6 years age. found detectable levels monoethyl phthalate (MEP), monobutyl (MBP), monobenzyl (MBzP), mono-(2-ethylhexyl) (MEHP) > 75% samples, suggesting widespread exposure United States diethyl phthalate, dibutyl diisobutylphthalate, benzylbutyl...
Using a novel and highly selective technique, we measured monoester metabolites of seven commonly used phthalates in urine samples from reference population 289 adult humans. This analytical approach allowed us to directly measure the individual phthalate responsible for animal reproductive developmental toxicity while avoiding contamination ubiquitous parent compounds. The monoesters with highest urinary levels found were monoethyl (95th percentile, 3,750 ppb, 2,610 microg/g creatinine),...
There is scientific and public concern about commonly used chemicals, including phthalates, that are associated with reproductive toxicity in laboratory animals hormonally active. People exposed to phthalates through diet, consumer products medical devices. The present study explored whether environmental levels of altered semen quality humans.We recruited 168 men who were part subfertile couples presented the Massachusetts General Hospital andrology for analysis between January 2000 April...
Myelomeningocele is one of the most common birth defects, characterized by a defect in bony spine and resultant extrusion spinal cord into sac filled with cerebrospinal fluid. It occurs 3 to 4 per 10,000 live births United States, death rate live-born infants this condition about 10%. has been suggested that final neurologic deficit results from failure neural-tube formation as well injury due prolonged exposure neural elements intrauterine environment, studies animal models have prenatal...
Because of the ubiquity phthalates and their potential role in increasing risk for cancer reproductive dysfunction, need human exposure assessment studies is urgent. In response to this need, we developed a high-throughput, robust, sensitive, accurate, precise assay simultaneous measurement trace levels eight phthalate metabolites urine by HPLC−MS/MS. Human samples were processed using enzymatic deconjugation glucuronides followed solid-phase extraction. The eluate was concentrated,...
Phthalates are ubiquitous in our modern environment because of their use plastics and cosmetic products. Phthalate monoesters--primarily monoethylhexyl phthalate monobutyl phthalate--are reproductive developmental toxicants animals. Accurate measures exposure needed to assess human health effects. monoesters have a biologic half-life approximately 12 hr, little is known about the temporal variability daily reproducibility urinary humans. To explore these aspects, we measured seven creatinine...
Phthalates are industrial chemicals widely used in many commercial applications. The general population is exposed to phthalates through consumer products as well diet and medical treatments. To determine whether environmental levels of associated with altered DNA integrity human sperm, we selected a without identified sources exposure phthalates. One hundred sixty-eight subjects recruited from the Massachusetts General Hospital Andrology Laboratory provided semen urine sample. Eight...
Polychlorinated biphenyls (PCBs) are persistent pollutants that ubiquitous in the food chain, and detectable amounts blood of almost every person most populations have been examined. Extensive evidence from animal studies shows PCBs neurotoxins, even at low doses. Interpretation human data regarding low-level, early-life PCB exposure subsequent neurodevelopment is problematic because levels were not similarly quantified across studies. We expressed 10 a uniform manner using combination...
No AccessJournal of UrologyPEDIATRIC UROLOGY1 Feb 2002CLINICAL OUTCOME OF PEDIATRIC STONE DISEASE PAUL K. PIETROW, JOHN C. POPE, MARK ADAMS, Y.U. SHYR, and W. BROCK PIETROWPAUL PIETROW , POPEJOHN POPE ADAMSMARK ADAMS SHYRY.U. SHYR BROCKJOHN View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69121-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The natural history stone disease in...
Background The steady worldwide increase in the incidence of non-Hodgkin lymphoma during past few decades remains mostly unexplained. Several studies suggest that there may be an association between agricultural use organochlorine 1,1,1-trichloro-2,2′bis(p-chlorophenyl)ethane (DDT) and increased risk lymphoma. We have investigated body burden selected organochlorines general population a nested case-control study. Methods measured prediagnostic serum concentrations DDT, its metabolites,...
The Management of Myelomeningocele Study (MOMS), a randomized trial prenatal versus postnatal repair for myelomeningocele, found that surgery resulted in reduced hindbrain herniation and need shunt diversion at 12 months age better motor function 30 months. In this study, we compared adaptive behavior other outcomes school (5.9-10.3 years) between groups.Follow-up cohort study 161 children enrolled MOMS. Assessments included neuropsychological physical evaluations. Children were evaluated...
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A substudy of the Management Myelomeningocele Study evaluating urological outcomes was conducted.Pregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The included patients after April 18, 2005. primary outcome defined in their children as death need for clean intermittent catheterization (CIC) by 30 months age characterized prespecified criteria. Secondary bladder and kidney abnormalities observed urodynamics...