Kinetic modeling using nonlinear differential equations is proposed to analyze the spontaneous generation of enantiomeric excess in autocatalytic addition diisopropylzinc prochiral pyrimidine carbaldehydes (Soai reaction). Our approach reproduces experimentally observed giant chiral amplification from an initial <10 –6 % >60%, high sensitivity and positive response presence minute amounts initiator at concentrations –14 M, absolute asymmetric synthesis achiral starting conditions. From...

The combination of racemic praziquantel, (RS)-PZQ, with aliphatic dicarboxylic acids the homologous series HOOC–(CH2)n–COOH (with n = 0–8) and unsaturated analogues succinic acid as cocrystal formers via liquid-assisted grinding provided a total nine 1:1 2:1 cocrystals oxalic acid, malonic (two polymorphic phases), maleic fumaric glutaric adipic pimelic acid. cocrystalline phases were identified first by XRPD analysis then structurally characterized IR spectroscopy and, far possible,...

Infections caused by the protozoans Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), and Trichomonas vaginalis (T. vaginalis) represent a global public health concern. Albendazole mebendazole are drugs used to treat parasitosis resulting from protozoa. However, low aqueous solubility of these compounds has led exploration new strategies enhance their solubility, with formation salts being commonly employed strategy. The sulfonates A1, A2, A3 albendazole, M1, M2, M3 were...

Infections from the protozoa Entamoeba histolytica (E. histolytica), Giardia lamblia (G. lamblia), and Trichomonas vaginalis (T. vaginalis) pose a public health issue, with albendazole mebendazole serving as second-line medications for treating these parasitic infections. However, low aqueous solubility of compounds has led to exploration new strategies enhance their solubility, formation salts being commonly employed strategy. The sulfonates A1, A2, A3 albendazole, along M1, M2, M3...

Combination of nitazoxanide (NTZ) with a total 32 cocrystal formers gave cocrystals succinic acid (NTZ-SUC, 2:1) and glutaric (NTZ-GLU, 1:1). Additionally, 2,5-dihydroxybenzoic provided solvate acetonitrile (NTZ-25DHBA-CH3CN, 1:1:1). All solid phases were characterized by X-ray powder diffraction analysis, IR spectroscopy, thermogravimetric differential scanning calorimetry, single-crystal analysis. Single-crystal crystallography revealed that NTZ the carboxylic linked in all three through...

Fluoroquinolones are extensively used antibiotics that generally prescribed as hydrochloride salts because the neutral forms display low solubility due to their zwitterionic character. Starting from of ciprofloxacin (CiHCl) or (S,S)-moxifloxacin (MoHCl) and 4-hydroxybenzoic acid (4HBA) a cocrystal former, two cocrystalline solids, CiHCl–4HBA MoHCl–4HBA, were obtained in salt/coformer stoichiometric ratio 1:1. The phases identified by X-ray powder diffraction analysis further characterized IR...

Numerical kinetic simulations have been employed to understand the origin of enantioselectivity reversal chiral beta-amino alcohol catalysts occurring in presence their achiral analogs autocatalytic addition diisopropylzinc pyrimidine carbaldehydes (Soai reaction). In a preceding work (Rivera Islas, J.; Lavabre, D.; Grevy, J. M.; HernAndez Lamoneda, R.; Rojas Cabrera, H.; Micheau, C.; Buhse, T. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 13743-13748), we provided possible explanation for...

Baclofen (BAC) is an important chiral active pharmaceutical ingredient for the treatment of specific neurological disorders that commercially available only as RS-BAC (racemate). Using liquid-assisted grinding technique, combination with DL-MA in 1:1 stoichiometric ratio yielded a crystalline solid phase mixture enantiomeric salts R-BAC:L-MA and S-BAC:D-MA. Single-crystals suitable SCXRD analysis were obtained by fractional crystallization from solution L-MA solvent ethyl acetate water....

Dapsone (DDS) is an antibacterial drug with well-known antioxidant properties. However, the behavior of its derivatives has not been well explored. In present work, activity 10 dapsone 4-substituted was determined by evaluation in two vitro models (DPPH radical scavenging assay and ferric reducing power). These imine 1-10 were obtained through condensation between DDS corresponding aromatic aldehydes 4-substuited. Three presented better results than determination DPPH (2, 9, 10). Likewise,...

Dapsone, formerly used to treat leprosy, now has wider therapeutic applications. As is the case for many agents, low aqueous solubility and high toxicity are main problems associated with its use. Derivatization of amino groups been widely explored but shows no significant improvements. Cocrystals have prepared understand not only structural properties, also dissolution rate. Few salts dapsone described. The title salts, C 12 H 13 N 2 O S + ·C 6 5 3 − ·H ·CH SO O, crystallize as hydrates...

Cold atmospheric plasma (CAP) has gained attention as a non-invasive therapeutic option in oncology due to its selective cytotoxicity against cancer cells. CAP produces complex mixture of reactive oxygen and nitrogen species (RONS), which induce oxidative stress, leading various forms cell death, including apoptosis, necrosis, autophagy, ferroptosis. These mechanisms allow target cells effectively while sparing healthy tissue, making it versatile tool treatment. This review explores the...

Purpose: To prepare dapsone tosylate salt (TD) and its two polymorphs (TD-I TD-II), study their intrinsic dissolution profiles preliminary anti-mycobacterium activity.Methods: The synthesized product was studied with respect to the effect of solvent selection, reaction temperature evaporation rate on solid phase obtained. were characterized using powder x-ray diffraction (PXRD), proton nuclear magnetic resonance (1H-NMR), Fourier transform infrared spectroscopy (FT-IR), differential scanning...