The exquisite sensitivity and frequency discrimination of mammalian hearing underlie the ability to understand complex speech in noise. This requires force generation by cochlear outer hair cells (OHCs) amplify basilar membrane traveling wave; however, it is unclear how amplification achieved with sharp tuning. Here we investigated origin tuning measuring sound-induced 2-D vibrations within mouse organ Corti <i>in vivo</i>. Our goal was determine transfer function relating radial shear...

We report the first fully automated detection of basal cell carcinoma (BCC), most commonly occurring type skin cancer, in human using polarization-sensitive optical coherence tomography (PS-OCT). Our proposed procedure entails building a machine-learning based classifier by extracting image features from two complementary contrasts offered PS-OCT, intensity and phase retardation (PR), selecting subset that yields with highest accuracy. achieved 95.4% sensitivity specificity, validated...

Neuromonitoring in naturalistic environments is of increasing interest for a variety research fields including psychology, economics, and productivity. Among functional neuromonitoring modalities, near-infrared spectroscopy (fNIRS) well regarded its potential miniaturization, good spatial temporal resolutions, resilience to motion artifacts. Historically, the large size high cost fNIRS systems have precluded widespread adoption technology. In this article, we describe first open source,...

White light endoscopy is widely used for diagnostic imaging of the interior organs and body cavities, but inability to correlate individual 2D images with 3D organ morphology limits its utility quantitative or longitudinal studies disease physiology cancer surveillance. As a result, most videos, which carry enormous data potential, are only real-time guidance discarded after collection. We present computational method reconstruct visualize model from an endoscopic video that captures shape...

SignificanceMany derivatives of optical coherence tomography (OCT) rely on the depth-dependent information sample in image. System effects, such as confocal effect and sensitivity fall-off, should be corrected to improve accuracy images derived from them.AimWe developed a new single-shot method extract combined fall-off functions remove system-generated effects OCT images.ApproachThe function is modeled linear combination basis whose coefficients are found two or more A-scans (or B-scans)...

A reusable manifold and companion software for dipstick urinalysis that eliminates many aspects are plagued by user error.

We describe a combination of fabrication techniques and general process to construct three-dimensional (3-D) phantom that mimics the size, macroscale structure, microscale surface topology, subsurface microstructure, optical properties, functional characteristics cancerous bladder. The also includes features are recognizable in white light (i.e., visual appearance blood vessels), making it suitable emulate bladder for emerging light+optical coherence tomography (OCT) cystoscopies other...

Smartphone devices have seen unprecedented technical innovation in computational power and optical imaging capabilities, making them potentially invaluable tools scientific applications. The smartphone’s compact form-factor broad accessibility has motivated researchers to develop smartphone-integrated systems for a wide array of Optical coherence tomography (OCT) is one such technique that could benefit from smartphone-integration. Here, we demonstrate smartOCT, OCT system leverages built-in...

We demonstrate the first application of differential depolarization index (DDI) for imaging in polarization-sensitive optical coherence tomography (PS-OCT). Unlike widely used degree polarization uniformity (DOPU), DDI is independent incident state and, therefore, more robust to varying system and sample parameters. Moreover, it can be applied single-input-polarization-state PS-OCT systems, overcomes several limitations emerging multiple-input-polarization-state systems. Our results on...

Computational spectroscopy breaks the inherent one-to-one spatial-to-spectral pixel mapping of traditional spectrometers by multiplexing spectral data over a given sensor region. Most computational require components that are complex to design, fabricate, or both. DiffuserSpec is simple spectrometer uses dispersion commercially available diffusers generate speckle patterns unique each wavelength. Using Scotch tape as diffuser, we demonstrate narrowband and broadband reconstructions with 2-nm...

The presence of human hair in the area sensing interest during functional near-infrared spectroscopy (fNIRS) procedures is a known factor that can prevent proper coupling with scalp, resulting signal loss and reduction signal-to-noise ratio (SNR). Researchers struggle to find technique for clearance accessible, simple time efficient operate, applicable many different characteristics – including length, shaft thickness, curl or coil, density. Our group has developed novel, mechanical...

Abstract Purpose In the current clinical standard of care, cystoscopic video is not routinely saved because it cumbersome to review. Instead, clinicians rely on brief procedure notes and still frames manage bladder pathology. Preserving discarded data via 3D reconstructions, which are convenient review, has potential improve patient care. However, many videos collected by fiberscopes, lower cost but induce a pattern that inhibits reconstruction. The aim this study remove honeycomb-like...

The attenuation coefficient is a relevant biomarker for many diagnostic medical applications. Recently, the Depth-Resolved Confocal (DRC) technique was developed to automatically estimate coefficients from Optical Coherence Tomography (OCT) data with pixel-level resolution. However, DRC requires that confocal function parameters (i.e., focal plane location and apparent Rayleigh range) be known priori. In this paper, we present autoConfocal algorithm: simple, automatic method estimating those...

This work demonstrates the combination of optical coherence tomography (OCT) and hyperspectral imaging (HSI) using a double-clad fiber coupler. The single-mode core is used for OCT imaging, while inner cladding provides an efficient way to capture reflectance spectrum sample. both methods enables three-dimensional acquisition sample morphology with OCT, enhanced complementary molecular information contained in image. HSI data can be highlight presence specific molecules characteristic...