A5061326445- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Tracheal and airway disorders
- Esophageal and GI Pathology
- Cancer Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Mycobacterium research and diagnosis
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Child Abuse and Related Trauma
- Bacillus and Francisella bacterial research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Respiratory viral infections research
- Esophageal Cancer Research and Treatment
- Hernia repair and management
- Pleural and Pulmonary Diseases
- Pneumonia and Respiratory Infections
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- Intestinal Malrotation and Obstruction Disorders
- Colorectal Cancer Treatments and Studies
- Anorectal Disease Treatments and Outcomes
- Spine and Intervertebral Disc Pathology
- Obstructive Sleep Apnea Research
The University of Texas Health Science Center at San Antonio
2020-2021
Baylor College of Medicine
2020-2021
Children's Hospital of San Antonio
2021
Albert Einstein College of Medicine
2021
University of Maryland, Baltimore
2021
Cedars-Sinai Medical Center
2021
Barnet Hospital
2000-2015
Royal Free London NHS Foundation Trust
2015
Urology San Antonio
2014
Cohen Children's Medical Center
2011-2013
Tracheostomy is a lifesaving intervention with numerous complications.We describe the natural history of tracheostomy in children defined geographical area over 17-year period. Our primary aim to stress need for consensus on pediatric care.This retrospective study reviewed charts 72 who had between January 1990 and 2007. Indications procedure were divided into 3 groups: (1) upper airway obstruction at well-defined anatomic site (32 patients); (2) complex medical condition (24 (3) an access...
PURPOSE: To test the hypotheses that (a) magnetic resonance (MR) imaging–guided radio-frequency (RF) thermal ablation of vertebrae is feasible in porcine models, (b) procedure safety depends on location within vertebra, and (c) MR imaging allows accurate monitoring induced lesion size shape. MATERIALS AND METHODS: Ten percutaneous RF ablations were randomized over various lumbar vertebral levels locations seven pigs. Animals followed up for 2, 7, or 14 days before sacrifice. Thermal shape as...
Colonic stenting has failed to show an improvement in mortality rates comparison with emergency surgery for acute large-bowel obstruction. However, it remains unclear which patients are more likely benefit from this procedure.The aim of study is identify factors that may be predictive successful outcome colonic obstruction.All undergoing obstruction between 1999 and 2013 were studied. The demographics characteristics the obstructing lesion analyzed.This investigation was conducted at a...
4043 Background: Interstitial fluid pressure (IFP) of most solid tumours is increased relative to normal tissues; this thought be associated with the development structurally and functionally abnormal blood lymphatic vessels interstitial fibrosis. Such hypertension creates a barrier for tumour transvascular transport, consequently compromising delivery efficacy chemotherapy. We investigated effect Bevacizumab on IFP human rectal cancer xenograft. Methods: SCID mice bearing subcutaneous HT29...
Newborns with Pierre Robin sequence (PRS) often experience chronic intermittent hypoxemia/hypoventilation associated airway obstruction. The heterogeneity of the severity upper obstruction makes management a challenge; optimal intervention in individual cases is not clear.To investigate prevalence surgical/nonsurgical interventions for PRS at two children's hospitals. Patient characteristics and outcomes were examined.The present retrospective chart review identified 139 patients born...
Abstract Patients with anaplastic thyroid carcinoma (ATC) typically succumb to their disease months after diagnosis despite aggressive therapy. A large percentage of ATCs have been shown harbor the V600E B-Raf point mutation, leading constitutive activation mitogen-activated protein kinase pathway. ATC invasion, metastasis, and angiogenesis are in part dependent on gelatinase class matrix metalloproteinases (MMP). The explicit targeting these two tumor markers may provide a novel therapeutic...
Vascular endothelial cadherin (VE-cad) is essential for barrier integrity and vascular sprouting. However, the role of this important protein in cardiovascular development only recently becoming apparent.To characterize VE-cadherin development, we analyzed a zebrafish VE-cad knockdown model. Embryos deficient show profoundly impaired cardiac despite having apparently normal peripheral vasculature. Initial formation heart proceeds normally embryos, but subsequent looping morphogenesis...
Randomized trials of ribavirin therapy have used clinical scores to assess illness severity. Little information on agreement for these findings between observers has been published. We decided determine interobserver (1) a history apnea or respiratory failure; (2) assessment cyanosis, rate, retractions, and oximetry; (3) determination reason hospitalization (requirement medications, supportive care, underlying illness, poor home environment). At eight centers 137 RSV-infected patients were...
BACKGROUND: Lymphovascular ligation before tumour manipulation during colorectal cancer resection is termed the 'no-touch isolation' technique. It aims to reduce intra-operative dissemination of cells. Recently, detection circulating cells has been enhanced by molecular biology techniques. This paper reviews evidence for no-touch isolation technique in light recent developments cell detection. METHODS: Studies investigating effect surgery on were identified a Medline search using subject...
Abstract Anaplastic thyroid carcinoma is an aggressive form of cancer with no treatment. Angiogenesis inhibitors, such as TNP-470, a synthetic derivative fumagillin, have been shown to reduce tumor size and increase survival in heterotopic animal models cancer. Our goals were determine the effect TNP-470 on anaplastic using orthotopic murine model, identify molecular pathways actions endothelial cells, non-endothelial effects TNP-470. We injected human cells (DRO′90) into glands nude mice....