A5060744783- Estrogen and related hormone effects
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Cytokine Signaling Pathways and Interactions
- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Insect and Pesticide Research
- Plant and animal studies
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- HIV Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Genomics and Chromatin Dynamics
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Insect and Arachnid Ecology and Behavior
- Carbohydrate Chemistry and Synthesis
- Histone Deacetylase Inhibitors Research
Northeastern University
2024
Barnard College
2024
University of Arkansas for Medical Sciences
1992-2006
Cancer Research Center
1994
The effectiveness of poly (ADP-ribose) polymerase inhibitors (PARPi) in creating single-stranded DNA gaps and inducing sensitivity requires the FANCJ helicase. Yet, how relates to PARP1 inhibition or trapping, which contribute PARPi toxicity, remains unclear. Here, we find hinges on S-phase activity, is reduced deficient cells as G-quadruplexes sequester MSH2. Additionally, loss FANCJ-MLH1 interaction diminishes activity; however, depleting MSH2 reinstates gaps. Indicating sequestered...
Recent global declines in bee health have elevated the need for a more complete understanding of cellular stress mechanisms employed by diverse species. We recently uncovered biomarker lethal (2) essential life [l(2)efl] genes as part shared transcriptional program response to number cell stressors western honey (Apis mellifera). Here, we describe another stress-responsive gene, glycine N-methyltransferase (Gnmt), which is known key metabolic switch controlling methylation reactions....
Glucocorticoid regulation of expression the protooncogene fos has been examined in AtT-20 cells at both RNA and protein levels. When were incubated continuously presence dexamethasone, an early (30 min) rise mRNA was observed, which declined by 1 h, but rose again after 2 h hormone treatment. Six hours treatment, levels had returned to control spite continued dexamethasone. Serum treatment resulted a sustained increase levels; however, glucocorticoid serum effects additive. Dexamethasone...
Abstract DNA G-quadruplexes (G4s) are secondary structures with significant roles in regulating genome function and stability. Dysregulation of the dynamic formation G4s is linked to genomic instability disease, but underlying mechanisms not fully understood. In this study, we conducted a screen chromatin-modifying enzymes identified nine potential inhibitors G4 formation, including seven that were previously characterized. Among these, highlight role BAZ2 chromatin remodelers as key...
SUMMARY Single-stranded DNA gaps are postulated to be fundamental the mechanism of anti-cancer drugs. Gaining insights into their induction could therefore pivotal for advancing therapeutic strategies. For poly (ADP-ribose) polymerase inhibitors (PARPi) effective, presence FANCJ helicase is required. However, relationship between dependent and PARP1 catalytic inhibition or trapping—both linked PARPi toxicity in BRCA deficient cells—is yet elucidated. Here, we find that efficacy contingent on...
13131 Background: Cancer results from accumulation of gene deregulations. DNA sequence alterations are unquestioned importance in this process, but not exclusive. Alterations function unaccounted for by changes (Epigenetic) quite common, and seem to contribute carcinogenesis. Abnormal methylation at the promoter region Tumor Suppressor Genes transcriptional silencing, is wide spread many cancers, including Breast (BC). cancer (DNAm) among best characterized epigenetic anomalies. An...