A5079853513- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac pacing and defibrillation studies
- Fuel Cells and Related Materials
- Congenital Heart Disease Studies
- Cardiovascular Function and Risk Factors
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Arrhythmias and Treatments
- Spectroscopy and Chemometric Analyses
- Smart Agriculture and AI
- Heart Failure Treatment and Management
- Hydraulic and Pneumatic Systems
- Platelet Disorders and Treatments
- Cardiac and Coronary Surgery Techniques
- Sensor Technology and Measurement Systems
- Cardiovascular Health and Disease Prevention
- Leaf Properties and Growth Measurement
- Remote Sensing in Agriculture
- Electrospun Nanofibers in Biomedical Applications
- Blood transfusion and management
- Microwave and Dielectric Measurement Techniques
- Tissue Engineering and Regenerative Medicine
- Membrane-based Ion Separation Techniques
Cleveland Clinic Lerner College of Medicine
2008-2020
Cleveland Clinic
2007-2020
Case Western Reserve University
2015-2020
M4 Engineering (United States)
2020
OSRAM (United States)
2015
National Heart Lung and Blood Institute
2015
National Institutes of Health
2015
Cerner (United States)
2009-2012
Cleveland Foundation
2005
Cleveland Clinic's continuous-flow total artificial heart has one motor and rotating assembly supported by a hydrodynamic bearing. The right hydraulic output is self regulated passive axial movement of the to balance itself with left output. purpose this article present progress in four areas development: automatic speed control system, self-regulation right/left inlet pressures flows, hemolysis testing using calf blood, coupled electromagnetics (EMAG) computational fluid dynamics (CFD)...
This study demonstrated the concept of using speed modulation in a continuous-flow total artificial heart (CFTAH) to shape arterial pressure waveforms and adjust pulsatility. A programmable function generator was used determine optimum pulsatile profile. Three profiles [sinusoidal, rectangular, optimized (a profile for generation physiologic waveform)] were evaluated CFTAH mock circulatory loop. Hemodynamic parameters recorded at average pump speeds 2,700 rpm cycle 60 beats per minute. The...
Cleveland Clinic's continuous-flow total artificial heart (CFTAH) provides systemic and pulmonary circulations using one assembly (one motor, two impellers). The right pump hydraulic output to the circulation is self-regulated by rotating assembly's passive axial movement in response atrial differential pressure balance itself left output. This combination of features integrates a biocompatible, pressure-balancing regulator with double-ended pump. CFTAH requires no flow or sensors. only...
Implantation of mechanical circulatory support devices is challenging, especially in patients with a small chest cavity. We evaluated how well the Cleveland Clinic continuous-flow total artificial heart (CFTAH) fit anatomy about to receive transplant. A mock pump model CFTAH was rapid-prototyped using biocompatible materials. The brought operative table, and direction, length, angulation inflow/outflow ports outflow conduits were after recipient's ventricles had been resected. Thoracic...
An implantable biventricular assist device offers a considerable opportunity to save the lives of patients with combined irreversible right and left ventricular failure. The purpose this study was evaluate hemodynamic physiologic performance implantation CorAide™ (LVAD) DexAide (RVAD). Acute responses were evaluated after simulating seven different physiological conditions in two calves. Evaluation performed by fixing speed one individual pump increasing other. Under all conditions,...
The DexAide right ventricular assist device (RVAD) is a magnetically and hydrodynamically levitated implantable centrifugal pump. Recent progress includes 1) redesign of the inflow/outflow conduits, which yielded two successful 3-month experiments, 2) development alternative journal bearing materials, 3) completion an 18-month duration in vitro endurance testing. Verification testing RVAD electronics has been completed, prototype biventricular (BVAD) system tested. Acute DexAide/CorAide BVAD...
Abstract OBJECTIVES Mechanical circulatory support has become standard therapy for adult patients with end-stage heart failure; however, in paediatric congenital disease, the options chronic mechanical are limited to paracorporeal devices or off-label use of intended implantation adults. Congenital disease and cardiomyopathy often involve both left right ventricles; such cases, transplantation, a biventricular assist device total artificial is needed adequately sustain pulmonary systemic...
The Cleveland Clinic continuous-flow total artificial heart passively regulates itself in regard to the relative performance of systemic and pulmonary pumps. system incorporates real-time monitoring detect any indication incipient left or right suction as input for automatic controller response. To recognize suction, external compares waveforms modulating speed power feedback. Deviations periodic indicate sudden changes flow impedance, which are characteristic events pump is modulating....
BackgroundThe Advanced ventricular assist device (Advanced VAD) is designed as a universal pump intended to prevent backflow in the event of stoppage, maintain physiological pulse pressure, and be used both left right VAD. The purpose this study was evaluate performance VAD an acute vivo calves.MethodsThe implanted through median sternotomy 5 healthy calves (weight, 71.4-91.2 kg) (n = 3) or 2). After implantation, hemodynamic parameters, including general were evaluated.ResultsThe...
The purpose of this program is to design, develop, and clinically evaluate a new, implantable right ventricular assist device (RVAD) that can be used as component an biventricular for patients with severe heart failure. initial phase resulted in prototype RVAD, named DexAide, modified version the CorAide left device. In vitro testing was performed stand-alone circuit true RVAD mode pump performance. Pump flow power were measured under various afterload speed conditions. performance...