A5036705114- Atrial Fibrillation Management and Outcomes
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Electronic Health Records Systems
- Pharmacovigilance and Adverse Drug Reactions
- Antibiotic Use and Resistance
- Cardiac Arrhythmias and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Pharmacogenetics and Drug Metabolism
- Healthcare Systems and Technology
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Analytical Methods in Pharmaceuticals
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Patient Satisfaction in Healthcare
- Poisoning and overdose treatments
- Acute Lymphoblastic Leukemia research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Childhood Cancer Survivors' Quality of Life
- Epilepsy research and treatment
- Pharmaceutical Economics and Policy
- Clinical Laboratory Practices and Quality Control
- Patient Safety and Medication Errors
Christchurch Hospital
2013-2025
University of Otago
2016-2025
Canterbury District Health Board
2012-2023
California Pacific Medical Center
2021
Sutter Health
2021
Christ University
2018
University of Pittsburgh
2016
Diabetes Australia
2008
Background Clozapine-induced gastrointestinal hypomotility and constipation can result in severe sometimes fatal complications. Laxatives should be prophylactically prescribed with clozapine, but this is inconsistently achieved. Digital clinical decision support (CDS) alerts promote safer prescribing. Aims To evaluate whether a CDS alert could timely laxative use clozapine hospital. Method Retrospective in-patient prescribing data was used to compare co-prescribing of laxatives for first...
Legionnaires' disease (LD) is typically treated with macrolides, including the azalide azithromycin, or quinolones. In 2013, guidelines for empirical treatment of community-acquired pneumonia at Christchurch Hospital, New Zealand were changed to prioritize oral azithromycin over IV clarithromycin. To determine whether change in antimicrobial led altered outcomes patients subsequently confirmed have LD. Patients LD between 2010 and 2020 identified from clinical laboratory data. Hospital...
Summary Background Up to 20% of patients on thiopurine therapy fail achieve adequate drug response. Many these preferentially produce the toxic 6‐methylmercaptopurine metabolites (6‐MMP) rather than active 6‐thioguanine nucleotides (6‐TGN) resulting in a high 6‐MMP/6‐TGN ratio (>20) and increased risk hepatotoxicity. Aim To determine prevalence preferential 6‐MMP producers define relationships between 6‐TGN, methyltransferase (TPMT). Methods The database TPMT measurements from throughout...
Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate use after a first major bleed on warfarin or dabigatran and, second, compare effectiveness and safety between patients discontinuing restarting dabigatran.Using 2010 2012 Medicare Part D data, we identified fibrillation who experienced bleeding event while using (n=1135) (n=404) categorized them by their of...
Dabigatran is largely cleared by renal excretion. Renal function thus a major determinant of trough dabigatran concentrations, which correlate with the risk thromboembolic and haemorrhagic outcomes. Current dosing guidelines use Cockcroft–Gault (CG) equation to gauge function, instead contemporary equations including Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) employing creatinine (CKD-EPI_Cr), cystatin C (CKD-EPI_Cys) both biomarkers (CKD-EPI_CrCys). A linear regression...
Pharmacogenetics has potential for optimizing use of psychotropics. CYP2D6 and CYP2C19 are two clinically relevant pharmacogenes in the prescribing antidepressants. Using cases recruited from Understanding Drug Reactions Genomic Sequencing (UDRUGS) study, we aimed to evaluate clinical utility genotyping antidepressant response. data patients who were prescribed antidepressants mental health disorders, experienced adverse reactions (ADRs) or ineffectiveness, extracted analysis....
Abstract Background/Aim We aimed to compared estimated glomerular filtration rate ( eGFR ) according the C hronic K idney D isease E pidemiology ollaboration equation CKD‐EPI ), with (mL/min/1.73 m 2 and without body surface area BSA normalisation _no , L /min) against measured 99m Technetium ‐ diethylenepentaacetic acid T c‐ DTPA GFR (m in 222 individuals, including 80 malignancy. Methods was calculated for each individual using u B ois equation. The CKD EPI equations were respect bias,...
Background: Pharmacokinetic studies and therapeutic drug monitoring of antibiotics require a simple, rapid, reliable analytical method for the concentrations in plasma, including unbound highly protein-bound drugs. The aim current work was to develop validate liquid chromatography–tandem mass spectrometry simultaneous determination total 3 widely used β-lactam (cefalexin, cefazolin, flucloxacillin) often coadministered probenecid human suitable pharmacokinetic routine use ordinary, busy...
Low vitamin D status is associated with increased risk of pneumonia, greater disease severity and poorer outcome. However, no trials have examined the effect adjunctive therapy on outcomes in adults community-acquired pneumonia (CAP). We conducted a randomised, double-blind, placebo-controlled trial examining effects hospitalised CAP. Participants were randomised to either single oral dose 200,000 IU D3 or placebo. The primary outcome was complete resolution chest radiograph infiltrate at 6...
Hepatic drug clearance is thought to be reduced with age. However for highly protein bound drugs, which are cleared by capacity-limited metabolism, studies on total have been conflicting. The hypothesis that binding decreases age has used explain this. Warfarin a drug, metabolism. There conflicting or little data the relationship between adult and free of (R)- (S)-warfarin.In clinical study 72 patients (18-89 years) warfarin therapy, both (R)-warfarin decreased For (S)-warfarin there was...
Background It is unclear which renal function equation, employing an isotope dilution mass spectrometry (IDMS)-aligned creatinine assay, best predicts gentamicin clearance. Methods The performances of the Cockcroft-Gault, Modification Diet in Renal Disease (MDRD) Study and Chronic Kidney Epidemiology Collaboration (CKD-EPI) equations for predicting clearances were assessed retrospectively 240 patients treated with during 2011–2012, when local assay was IDMS-aligned. Comparisons based on...
A busulfan concentration monitoring and dosing service has been provided by Christchurch Hospital since 1998. This study aimed to see (1) the percentage of patients with an area under time curve (AUC) outside target range had dose adjustment, (2) how clearance (CL) relates body weight, (3) if fewer samples could be used predict doses.Blood were taken from after oral administration, usually at 0.5, 1, 1.5, 6 hours, start a 2-hour intravenous (IV) infusion busulfan, 2, 2.5, 3, 6, 8 hours. Dose...
Omeprazole is extensively used to manage gastroesophageal reflux disease (GERD). It primarily metabolized by CYP2C19. The CYP2C19*17 (rs12248560) allele and the recently described CYP2C:TG haplotype (rs11188059 rs2860840) are associated with increased enzymatic activity, may reduce omeprazole exposure. This observational study aimed investigate association between these genetic variants treatment failure in GERD. We recruited predominantly New Zealand European GERD patients who either did...
Individualized drug dosing is a major pursuit in clinical pharmacology. The principal covariates that determine maintenance dose rates are the renal and hepatic function of individual [1]. process individualization most clear for drugs renally cleared as there established indices can be employed to gauge thus guide dosing. Pharmaceutical companies tend promote 'one size fits all' approach interests simplicity. In following commentary, we review dabigatran etexilate, eliminated was initially...
Extended interval dosing (EID) of gentamicin most commonly involves every 24 hours, but patients with impaired renal function may require a longer dose interval. This study examines large database treated from 1996 to 2010 see how many impairment would have benefited intervals >24 hours and define the incidence nephrotoxicity.All aged ≥ 16 years who had received by EID over 14-year period concentration data available were examined. End points included numbers (%) achieving target peak...
Aims In patients with atrial fibrillation prescribed dabigatran, the aim was to examine correlation between plasma dabigatran concentrations and three screening coagulation assays [international normalized ratio ( INR ), activated partial thromboplastin time (a PTT ) thrombin TT )] as well dilute dTT contribution of fibrinogen variability in results. Methods Plasma from on were analysed for clotting times dabigatran. Correlation plots (and associated r 2 values) generated using these data....