A5058827919- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Bacteriophages and microbial interactions
- Molecular Biology Techniques and Applications
- Inflammatory mediators and NSAID effects
- Metabolomics and Mass Spectrometry Studies
- Gastrointestinal motility and disorders
- Computational Drug Discovery Methods
- Mental Health Research Topics
- Treatment of Major Depression
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- CRISPR and Genetic Engineering
- Receptor Mechanisms and Signaling
- Lipoproteins and Cardiovascular Health
- Eicosanoids and Hypertension Pharmacology
Shenandoah University
2025
University of Otago
2020-2024
CYP2D6 activity has been inconsistently associated with anxious and depressive personality traits. The inconsistency may stem from limitations of targeted genotyping, employed in most previous studies, leading to undetected errors metabolic classification. Using a nanopore sequencing-based method, we comprehensively genotyped alleles small cohort 96 Malaysians re-examined the relationship between susceptibility anxiety depression. In keeping prior CYP2D6*10 was found be common defective...
Pharmacogenetics has potential for optimizing use of psychotropics. CYP2D6 and CYP2C19 are two clinically relevant pharmacogenes in the prescribing antidepressants. Using cases recruited from Understanding Drug Reactions Genomic Sequencing (UDRUGS) study, we aimed to evaluate clinical utility genotyping antidepressant response. data patients who were prescribed antidepressants mental health disorders, experienced adverse reactions (ADRs) or ineffectiveness, extracted analysis....
Omeprazole is extensively used to manage gastroesophageal reflux disease (GERD). It primarily metabolized by CYP2C19. The CYP2C19*17 (rs12248560) allele and the recently described CYP2C:TG haplotype (rs11188059 rs2860840) are associated with increased enzymatic activity, may reduce omeprazole exposure. This observational study aimed investigate association between these genetic variants treatment failure in GERD. We recruited predominantly New Zealand European GERD patients who either did...
The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to predisposing adverse reactions. majority research on the CYP2D6 gene has been carried out European East Asian populations, with Indigenous minority such as those from Oceania, greatly underrepresented. However, genetic is often...
<title>Abstract</title> Objective CYP2D6 activity has been inconsistently associated with anxious and depressive personality traits. The inconsistency may stem from limitations of targeted genotyping, employed in most previous studies, leading to undetected errors metabolic classification. Using a nanopore sequencing-based method, we comprehensively genotyped <italic>CYP2D6</italic> alleles small cohort 96 Malaysians re-examined the relationship between susceptibility anxiety depression....
Abstract The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to predisposing adverse reactions. majority research on the CYP2D6 gene has been carried out European East Asian populations, with Indigenous minority populations greatly underrepresented. However, genetic is often...