A5078992808- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Biosensors and Analytical Detection
- Conducting polymers and applications
- Electrochemical sensors and biosensors
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Sensors
- Advanced Chemical Sensor Technologies
- Forensic Toxicology and Drug Analysis
- Molecular Sensors and Ion Detection
- Organic Light-Emitting Diodes Research
- Organic Electronics and Photovoltaics
- Luminescence and Fluorescent Materials
- Advanced Biosensing Techniques and Applications
- Forensic and Genetic Research
- Epigenetics and DNA Methylation
- Photochromic and Fluorescence Chemistry
- Mass Spectrometry Techniques and Applications
- Crystallography and molecular interactions
- Cannabis and Cannabinoid Research
- Monoclonal and Polyclonal Antibodies Research
- Photoreceptor and optogenetics research
- Psychedelics and Drug Studies
- Bacterial biofilms and quorum sensing
University of Strathclyde
2015-2024
Glasgow Life
2014-2021
International Union of Pure and Applied Chemistry
2006-2020
Dublin City University
2003-2012
ARC Centre of Excellence for Electromaterials Science
2008-2011
University of Wollongong
2007-2011
University of Warwick
2007
La Trobe University
2006
University of Connecticut
2003-2004
UConn Health
2003-2004
Direct electrochemiluminescence (ECL) involving DNA was demonstrated in 10 nm films of cationic polymer [Ru(bpy)(2)(PVP)(10)](2+) assembled layer-by-layer with DNA. A square wave voltammetric waveform oxidized the Ru(II) sites metallopolymer to Ru(III), and ECL measured simultaneously catalytic peaks a simple apparatus. Significant generation occurred only when guanine bases were present on oligonucleotides films. This result along knowledge proposed pathways suggests that radicals initially...
Direct detection of medically relevant biomarkers in whole blood without the need for pretreatment or extraction is a great challenge biomedical analysis and diagnosis. Electrochemical techniques, such as electrochemiluminescence (ECL), are promising tools this area analysis. ECL offers high sensitivities together with ability to obtain time spacial control over process. This work exploits these features low background signals obtained from clearly identify quantify dopamine relative...
An electroactive nitrospiropyran-substituted polyterthiophene, poly(2-(3,3′′-dimethylindoline-6′-nitrobenzospiropyranyl)ethyl 4,4′′-didecyloxy-2,2′:5′,2′′-terthiophene-3′-acetate), has been synthesized for the first time. The spiropyran, incorporated into polymer backbone by covalent attachment to alkoxyterthiophene monomer units, leads multiple colored states as a result of both photochemical and electrochemical isomerization spiropyran moiety merocyanine forms well oxidation...
Direct electrochemiluminescence (ECL) involving oxidized DNA was demonstrated in ultrathin films of cationic polymer [Os(bpy)2(PVP)10]2+ [PVP = poly(vinyl pyridine)] assembled layer-by-layer with or oligonucleotides. Electrochemically Os(II) sites generated ECL from containing oxo-guanines on formed by chemical oxidation using Fenton reagent. Films combining DNA, [Ru(bpy)2(PVP)10]2+, and had that produced specific for Ru(II) gave reaction oxo-adenines, chemically damaged possibly cleaved strands.
Water soluble positively charged 2-(dimethylamino)ethanethiol (DAET)-protected core-shell CdSe/ZnS quantum dots (QDs) were synthesized and incorporated within negatively Nafion polymer films. The water QDs characterized using UV-visible fluorescence spectroscopies. Nafion/QDs composite films deposited on glassy carbon electrodes cyclic voltammetry. electrochemiluminescence (ECL) hydrogen peroxide as co-reactant was enhanced for compared to of the bare QDs. Significantly, no ECL observed when...
Mammalian ageing features biological attrition evident at cellular, genetic and epigenetic levels. Mutation of mitochondrial DNA, nuclear DNA methylation changes are well established correlates ageing. The (mtDNA) is a new incompletely described phenomenon with unknown control significance. Here we describe the bisulphite sequencing mtDNA from 82 individuals aged 18‐91 years. We detected low variable levels 54 133 CpG sites interrogated. Regression analysis two (M1215 M1313) located within...
The expansion of electrochemical sensors to biomedical applications at point care requires these undergo analysis without any pretreatment or extraction. This poses a major challenge for all including electrochemiluminescent (ECL)-based sensors. ECL offers many advantages applications; however, obtaining results from complex matrixes has proven be large hurdle the application within this field. work demonstrates potential cathodic detect and quantify homocysteine (Hcy) with 0.1 nM limit...
A major challenge within forensic science is the development of accurate and robust methodologies that can be utilized on-site for detection at crime scenes used analyzing multiple sample types. The recent expansion electrochemical sensors to tackle this hurdle requires undergo analysis without any pretreatment. Given vast array samples are submitted analysis, pose a all sensors, including electrochemiluminescent (ECL)-based sensors. Within contribution, we demonstrate capacity an ECL-based...
The effect of surface confinement on the electrochemiluminescence (ECL) properties metallopolymer [Ru(bpy)2(PVP)10]2+, where bpy is 2,2'-bipyridyl and PVP poly(4-vinylpyridine), reported. Immobilizing a luminescent material an electrode can substantially modulate its photophysical properties. Significantly, our study revealed that overall efficiency ECL reaction for film almost four times higher, at 0.15%, than highest value obtained [Ru(bpy)2(PVP)10]2+ dissolved in solution, (φECL = 0.04%)....
The properties of two forms polyaniline (PAni) synthesised under acidic and basic conditions have been investigated both individually as combined complexes. PAni polymerised within alkaline media was redox inactive non-conducting while the emeraldine salt (ES) electroactive conducting. Raman, electron spin resonance, UV-Vis fluorescence spectroscopies were used to monitor changes in electronic these conducting polymer composites. Solution cast films (A-PAni) with ES resulted an increase high...
Significance Proponents of the altered states consciousness (ASC) model have argued that hallucinogens influenced prehistoric making images in caves and rock shelters. However, lack direct evidence for consumption at any global art site has undermined ASC model. We present first clear ingestion a site, this case, from Pinwheel Cave, California. Quids cave ceiling are shown to be Datura wrightii , Native Californian entheogen, indicating that, rather than illustrating visual phenomena caused...
A simple procedure to incorporate tris(2-2'-bipyridyl)ruthenium(II), [Ru(bpy)3]2+, into Nafion Langmuir−Schaefer (LS) films is described. LS (tens of nanometers thick) were formed on quartz glass and indium tin oxide (ITO) directly from Nafion−[Ru(bpy)3]2+ Langmuir assembled at the water−air interface. This allowed direct incorporation [Ru(bpy)3]2+ without need for subsequent loading. UV−vis spectroscopy confirmed successful within showed that amount immobilized in this way scaled with film...
The use of nanostructured carbon materials as electrodes for energy storage and conversion is an expanding area research in recent years. Herein, platinum nanoparticles have been deposited onto both multi-walled single-walled nanotubes (CNTs) via a microwave assisted polyol reduction method. This interaction has probed with electron paramagnetic resonance (EPR) Raman spectroscopies to elucidate the charge/electron transfer interactions between Pt CNTs. Observed shifts g factors CNTs are...
Chemical surface treatment of porphyrin-sensitised titania films using bis-(4-methoxyphenyl)phosphinic acid after dye adsorption, results in large improvements DSSC efficiencies which originate primarily from higher short circuit currents. The result was attributed to a positive shift the TiO2 quasi-Fermi level with simultaneous retardation charge recombination. High device performances have been achieved even simplified electrolyte matrices devoid common additives, LiI and t-butylpyridine.
The stepwise fabrication of the sensor is highlighted, scFv immobilization, binding pentameric CRP followed by metal labeled fragments.
Electrochemiluminescent sensors for point-of-care devices; a screening strategy the direct detection of hallucinogens within variety biological matrices.
Exploration of potential-dependent, multi-colour co-reactant electrochemiluminescence from multiple luminophores at the working and counter electrodes reveals new pathways to emission.
The electrochemiluminescent (ECL) properties of a luminescent metal centre, [Ru(bpy)(3)](2+), can be significantly modulated through its electronic interaction with neighbouring centres and the polymer backbone used to confine it on an electrode surface. From perspective ECL based sensing devices, increase in efficiency metallopolymer film result enhanced sensor sensitivity selectivity. This work probes both conjugated, [Ru(bpy)(2)(PPyBBIM)(10)](2+), non-conjugated,...