A5045117180- Polyoxometalates: Synthesis and Applications
- Metal complexes synthesis and properties
- Trace Elements in Health
- Metal-Organic Frameworks: Synthesis and Applications
- Metalloenzymes and iron-sulfur proteins
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Electrochemical Analysis and Applications
- Advanced Nanomaterials in Catalysis
- Chemical Synthesis and Reactions
- Organometallic Complex Synthesis and Catalysis
- Vanadium and Halogenation Chemistry
- X-ray Diffraction in Crystallography
- Electron Spin Resonance Studies
- Alzheimer's disease research and treatments
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Catalysis and Oxidation Reactions
- Radioactive element chemistry and processing
- Porphyrin and Phthalocyanine Chemistry
- Advanced NMR Techniques and Applications
- Organometallic Compounds Synthesis and Characterization
- Electrocatalysts for Energy Conversion
- Electrochemical sensors and biosensors
- Enzyme Structure and Function
The University of Melbourne
2009-2019
Biotechnology Institute
2006-2017
In-Q-Tel
2013-2017
Monash University
1999-2011
Stanford University
1998-2010
Stanford Synchrotron Radiation Lightsource
1998-2010
Centenary Institute
2009
Walter and Eliza Hall Institute of Medical Research
2009
Western Michigan University
2007
Washington State University
2004-2006
Literature estimates of metal-protein affinities are widely scattered for many systems, as highlighted by the class metallo-chaperone proteins, which includes human Atox1. The discrepancies may be attributed to unreliable detection probes and/or inconsistent affinity standards. In this study, application four Cu(I) ligand bicinchoninate, bathocuproine disulfonate, dithiothreitol (Dtt), and glutathione (GSH) is reviewed, their re-estimated unified. Excess bicinchoninate or disulfonate reacts...
Two gas-phase catalytic cycles for the two-electron oxidation of primary and secondary alcohols were detected by multistage mass spectrometry experiments. A binuclear dimolybdate center [Mo2O6(OCHR2)]- acts as catalyst in both these cycles. The first cycle proceeds via three steps: (1) reaction [Mo2O6(OH)]- with alcohol R2HCOH elimination water to form [Mo2O6(OCHR2)]-; (2) alkoxo ligand its aldehyde or ketone rate-determining step; (3) regeneration nitromethane. Step 2 does not occur at room...
The cytosolic C-terminal domain of the membrane copper transporter Ctr1 from yeast Saccharomyces cerevisiae, Ctr1c, was expressed in E. coli as an oxygen-sensitive soluble protein with no significant secondary structure. Visible-UV spectroscopy demonstrated that Ctr1c bound four Cu(I) ions, structurally identified a Cu(I)(4)(micro-S-Cys)(6) cluster by Xray absorption spectroscopy. This only metalated form detected electrospray ionization mass spectrometry. An average dissociation constant...
Bis(thiosemicarbazonato) complexes CuII(Btsc) have attracted interest as promising metallodrugs and, in particular, copper radiopharmaceuticals. Prototypes Cu(Atsm) and Cu(Gtsm) are membrane-permeable, but their metabolisms cells distinctly different: that is delivered by trapped nonselectively all cells, whereas retained selectively hypoxic "washed out" readily normal cells. We studied copper-transfer reactions of these two under various conditions, aiming to model cellular chemistry. In...
Reference potential scales are not generally available in ionic liquids. Consequently, comparison of data with those obtained conventional solvent (electrolyte) media is possible. The process [Co(Cp)2](+/0) (Co(Cp)2 = cobaltocene) has been studied at gold, glassy carbon and platinum macrodisk electrodes to test the feasibility using this redox couple as a voltammetric reference standard liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]). A reversible, one-electron...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic interactions in metal complexes of binucleating ligands. 2. Synthesis and properties binuclear copper(II) compounds containing exogenous ligands that bridge through two atoms. Crystal molecular structure a .mu.-pyrazolato-N,N'-bridged dicopper(II) complex 1,3-bis(salicylideneamino)propan-2-olWaldemar Mazurek, Brendan J. Kennedy, Keith S. Murray, Maxwell O'Connor, John R. Rodgers, Michael Snow, Anthony G. Wedd, Peter ZwackCite this: Inorg....
CopC is a small soluble protein expressed in the periplasm of Pseudomonas syringae pathovar tomato as part its copper resistance response (cop operon). Equilibrium competition reactions confirmed two separated binding sites with high affinities for CuI (10-7 ≥ KD 10-13 M) and CuII (KD = 10-13(1) M), respectively. While CuI-CopC was converted cleanly by O2 to CuII-CopC, fully loaded form CuICuII-CopC stable air. Variant forms H1F H91F exhibited lower affinity than does wild-type while variant...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of complexes thiomolybdates thiotungstates with copper(I) silver(I) cyanides, including molybdenum-95 tungsten-183 NMR properties the crystal molecular structures (n-Pr4N)2[(CN)CuS2MoS2], (n-Pr4N)2[(CN)AgS2WS2], (Ph4As)2[(CN)CuS2MoS2Cu(CN)].H2OStephen F. Gheller, Trevor W. Hambley, John R. Rodgers, Robert T. C. Brownlee, Maxwell J. O'Connor, Michael Snow, Anthony G. WeddCite this: Inorg. Chem. 1984, 23, 16,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic properties of thiolate compounds oxomolybdenum(V) and their tungsten selenium analogs. Effects oxygen-17, molybdenum-98, molybdenum-95 isotope substitution upon ESR spectraGraeme R. Hanson, Andrew A. Brunette, Angus C. McDonell, Keith S. Murray, Anthony G. WeddCite this: J. Am. Chem. Soc. 1981, 103, 8, 1953–1959Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic interactions in metal complexes of pentadentate binucleating ligands. 1. Synthesis and properties binuclear copper(II) compounds containing single-atom-bridging Crystal molecular structure a .mu.-hydroxo-bridged complex 1,5-bis[1-(pyridin-2-yl)ethylideneamino]pentan-3-olWaldemar Mazurek, Kevin J. Berry, Keith S. Murray, Maxwell O'Connor, Michael R. Snow, Anthony G. WeddCite this: Inorg. Chem. 1982, 21, 8, 3071–3080Publication Date...
CueO from Escherichia coli is a multicopper oxidase (MCO) involved in copper tolerance under aerobic conditions. It features four atoms that act as electron transfer (T1) and dioxygen reduction (T2, T3; trinuclear) sites. In addition, it displays methionine-rich insert which includes helix blocks physical access to the T1 site provides an extra labile T4 adjacent center. This required for function. Like many MCOs, exhibits phenol activity with broad substrate specificity. Maximal model...
Oxidative photocurrents measured upon irradiation by a 7-W visible light (wavelength 312-700 nm) demonstrated that the sulfo-polyoxometalate anion clusters [S2W18O62]4- (1a), [S2Mo18O62]4- (1b), and [SMo12O40]2- (2) may be activated photochemically to oxidize organic substrates benzyl alcohol, ethanol, (-)-menthol. In case of catalytic photooxidation alcohol benzaldehyde in presence 1a, quantitative electrochemical methods have identified pathways for oxidation reduced forms 1 generated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA single model displaying all the important centers and processes involved in catalysis by molybdoenzymes containing [MoVIO2]2+ active sitesZhiguang Xiao, Charles G. Young, John H. Enemark, Anthony WeddCite this: J. Am. Chem. Soc. 1992, 114, 23, 9194–9195Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolybdenum(VI) and molybdenum(V) complexes with N,N'-dimethyl-N,N'-bis(2-mercaptophenyl)ethylenediamine. Electrochemical electron paramagnetic resonance models for the molybdenum(VI/V) centers of molybdenum hydroxylases related enzymesDulal Dowerah, Jack T. Spence, Raghuvir Singh, Anthony G. Wedd, Graham L. Wilson, Frank Farchione, John H. Enemark, Kristofzski, Michael BruckCite this: J. Am. Chem. Soc. 1987, 109, 19, 5655–5665Publication Date...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolybdenum(V) sites in xanthine oxidase and relevant analog complexes: comparison of oxygen-17 hyperfine couplingRichard J. Greenwood, Graham L. Wilson, John R. Pilbrow, Anthony G. WeddCite this: Am. Chem. Soc. 1993, 115, 13, 5385–5392Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/ja00066a005https://doi.org/10.1021/ja00066a005research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolybdenum(V) sites in xanthine oxidase and relevant analog complexes: comparison of molybdenum-95 sulfur-33 hyperfine couplingGraham L. Wilson, Richard J. Greenwood, John R. Pilbrow, Jack T. Spence, Anthony G. WeddCite this: Am. Chem. Soc. 1991, 113, 18, 6803–6812Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplications of molybdenum-95 NMR spectroscopy. 7. Studies metal-metal bonded systems including aqueous molybdenum(IV) and molybdenum(V). Crystal molecular structure Na2[Mo3O4((O2CCH2)2NCH3)3].7H2OStephen F. Gheller, Trevor W. Hambley, Robert T. C. Brownlee, Maxwell J. O'Connor, Michael R. Snow, Anthony G. WeddCite this: Am. Chem. Soc. 1983, 105, 6, 1527–1532Publication Date (Print):March 1, 1983Publication History Published online1 May...
Copper plays essential roles in biology, but abnormal interactions are damaging. Reliable quantification of copper–protein will underpin the molecular understanding copper nutrition and toxicity. We have previously established two high affinity probes, Bathocuproine disulfonate (Bcs) Bicinchoninate (Bca) anions, that capable vitro Cu(i) binding with affinities from pico- to atto-molar concentrations. Quantitative probes required for lower proteins peptides typically associated...