A5021275609- Digestive system and related health
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Zebrafish Biomedical Research Applications
- Infant Nutrition and Health
- Wnt/β-catenin signaling in development and cancer
- Pancreatic function and diabetes
- Eosinophilic Esophagitis
- Health and Medical Studies
- Mycobacterium research and diagnosis
- Cancer Cells and Metastasis
- Congenital heart defects research
University of Würzburg
2022
Max Planck Institute for Infection Biology
2020
TU Dresden
2017
Objective The epithelial layer of the GI tract is equipped with innate immune receptors to sense invading pathogens. Dysregulation in signalling pathways associated severe inflammatory diseases, but responsiveness cells bacterial stimulation remains unclear. Design We generated 42 lines human and murine organoids from gastric intestinal segments both adult fetal tissues. Genome-wide RNA-seq provides an expression atlas epithelium. response was assessed using several functional assays...
The proliferative and functional heterogeneity among seemingly uniform cells is a universal phenomenon. Identifying the underlying factors requires single-cell analysis of function proliferation. Here we show that pancreatic beta-cells in zebrafish exhibit different growth-promoting properties, which part reflect differences time elapsed since birth cells. Calcium imaging shows embryonic islet become during early development. At later stages, younger join following differentiation from...
Abstract The human gastric epithelium forms highly organized gland structures with different subtypes of cells. carcinogenic bacterium Helicobacter pylori can attach to cells and subsequently translocate its virulence factor CagA, but the possible host cell tropism H. is currently unknown. Here, we report that preferentially attaches differentiated in pit region units. Single-cell RNA-seq shows organoid-derived monolayers recapitulate region, while organoids capture Using these models, show...
Epstein-Barr virus (EBV) is best known for infection of B cells, in which it usually establishes an asymptomatic lifelong infection, but also associated with the development multiple cell lymphomas. EBV infects epithelial cells and all cases undifferentiated nasopharyngeal carcinoma (NPC). etiologically linked at least 8% gastric cancer (EBVaGC) that comprises a genetically epigenetically distinct subset GC. Although we have very good understanding entry lymphomagenesis, sequence events...