A5041533406- Immune Cell Function and Interaction
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Pharmacological Receptor Mechanisms and Effects
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Berberine and alkaloids research
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Biochemical and Structural Characterization
- Respiratory and Cough-Related Research
- Toxin Mechanisms and Immunotoxins
Rambam Health Care Campus
2021-2024
University of Haifa
2013-2017
Western Galilee Hospital
2017
Cytokine storm refers to the dysregulated production of inflammatory mediators leading hyperinflammation. They are often detrimental, and worsen severity COVID-19 other infectious or diseases. Cannabinoids known have anti-inflammatory effects but their possible therapeutic value on cytokine storms has not been fully elucidated. In vivo ex studies were carried out investigate high-THC high-CBD extracts in immune cells. Significant differences between observed. Subsequent experiments focusing...
The resolution of acute inflammation is hallmarked by the apoptotic death inflammatory polymorphonuclear (PMN) cells, followed their clearance macrophages. In turn, resolution-phase macrophages exert reduced proinflammatory cytokine production, termed immune silencing. this study, we found that atypical chemokine receptor D6 plays an important and scavenging-independent role in promoting macrophage-mediated resolution. D6(-/-) mice displayed increased numbers (2.2-fold increase), but not...
Abstract The engulfment of apoptotic polymorphonuclear cells (PMN) during the resolution inflammation leads to macrophage reprogramming culminating in reduced proinflammatory and increased anti-inflammatory mediator secretion. atypical chemokine receptor D6/ACKR2 is expressed on PMN plays an important role regulating properties after engulfment. In this study, we found that inflammatory CCL5 mostly retained (75%) zymosan A peritonitis mice. Moreover, secreted by resolution-phase macrophages...
Background/Objectives: Asthma is a chronic inflammatory disorder of the airways affecting over 10% global population. It characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly type 2 helper T cells (Th2) innate lymphoid (ILC2s) in subset patients. However, significant portion asthmatic individuals present with "type 2-low" asthma, often refractory to standard inhaled corticosteroid (ICS) therapy. Therefore,...
Asthma is a chronic inflammatory disorder of the airways affecting over 10% global population. It characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly type 2 helper T cells (Th2) innate lymphoid (ILC2s) in subset patients. However, significant portion asthmatic individuals present with "type 2-low" asthma that often refractory to standard inhaled corticosteroid (ICS) therapy. Therefore, developing innovative therapeutic...
Abstract The engulfment of apoptotic leukocytes (efferocytosis) by macrophages during the resolution inflammation is essential for homeostasis and results in macrophage reprogramming/immune-silencing. Here, we show CD11bhigh convert to CD11blow ones stop efferocytosing PMN after reaching an threshold vivo. In addition, are distinct from either M1 or M2 their protein expression profile display pro-resolving properties, such as diminished responses different TLR ligands ex vivo propensity...