A5044037947- Cerebral Palsy and Movement Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Lower Extremity Biomechanics and Pathologies
- Sports injuries and prevention
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- Foot and Ankle Surgery
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Musculoskeletal pain and rehabilitation
- Coffee research and impacts
- Stroke Rehabilitation and Recovery
- Sports Performance and Training
- Neuroscience and Neural Engineering
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Botulinum Toxin and Related Neurological Disorders
University of Alabama at Birmingham
2018-2024
East Carolina University
2016-2018
University of Memphis
2015-2016
Abstract The purpose of this study was to investigate the interaction foot strike and common speeds on sagittal plane ankle knee joint kinetics in competitive rear (RFS) runners when running with a RFS pattern an imposed forefoot (FFS) pattern. Sixteen habitual male ran at two different (i.e. 8 6 min mile −1 ) using their FFS A repeated measures analysis variance used assess potential between speed for selected ground reaction force (GRF) variables and, kinematic kinetic variables. No...
Theacrine is a purine alkaloid found primarily in the leaves of Camellia Kucha plant and now included within dietary supplements. To compare effects theacrine-containing supplement with caffeine placebo on energy mood, as well objective measures cognitive performance, heart rate, blood pressure, 10 healthy men (20.8 ± 0.7 years) women (22.2 1.1 ingested TheaTrim (Purus Labs; containing branded form theacrine (Teacrine™) (150 mg)), only mg), or three different days, separated by approximately...
ABSTRACT Background Dystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms PD, whether dystonia associated with specific electrophysiological features unclear. Objective The objective this study was investigate subcortical and cortical field potentials at rest during contralateral hand foot movements in patients PD without dystonia. Methods We examined prevalence distribution...
Abstract The subthalamic nucleus (STN) is a primary target for Parkinson's disease (PD) neuromodulation therapies, yet its role in sensorimotor neural circuits remains unclear. We investigated the neuronal activity dorsolateral STN during visually cued isometric grip-force task contralateral hand humans with PD who were undergoing deep brain stimulation surgery. found significant force-related changes unit activity, especially immediately after force onset and offset, but minimal movement...
Directional deep brain stimulation (DBS) provides more precise control of current spread than conventional ring-shaped electrodes. Whether this enhanced flexibility improves motor function is unclear. Here we examine whether directional and circular differentially impact performance in patients with Parkinson's disease. Motor behaviors were assessed 31 who underwent unilateral subthalamic nucleus surgery (SUNDIAL, NCT03353688). Eight configurations, including 6 contacts their corresponding...
Locomotor adaptation relies on processes of both the peripheral and central nervous systems that may be compromised with advanced age (e.g., proprioception, sensorimotor integration). Age-related changes to these result in reduced rates locomotor under normal conditions should cause older adults disproportionately more affected by sensory manipulations during compared younger adults. 17 10 completed five separate 5-minute split-belt walking trials: three conditions, one 30% bodyweight...
Introduction: Although deep brain stimulation (DBS) often improves levodopa-responsive gait symptoms, robust therapies for dysfunction from Parkinson's disease (PD) remain a major unmet need. Walking speed could represent simple, integrated tool to assess DBS efficacy but is not examined systematically or quantitatively during programming. Here we investigate the reliability and functional significance of changes in by directional subthalamic nucleus. Methods: Nineteen patients underwent...
To facilitate movement through mechanically complex environments, terrestrial animals have evolved locomotor systems capable of flexibly altering internal mechanics to meet external demands. They do this by shifting imposed workloads between joints/muscle groups (central mechanical flexibility) and/or the function individual (local flexibility). In human locomotion research, central flexibility is well established and regularly reported. Local at major lower extremity joints muscle groups,...
Purpose To establish criterion and construct validity of a novel, clinically feasible assessment lower-extremity dexterity for PD patients.Methods Thirty-three patients performed unilateral task “off” “on” dopaminergic medications with each leg. The involves iteratively tapping targets the foot in specified pattern, measured outcome is time to complete movement sequence, longer times indicating worse performance. We correlated leg standard, validated measures gait (comfortable maximal walk...
ABSTRACT Directional brain stimulation provides greater control of radial current spread than conventional ring-shaped electrodes. Whether this added flexibility can improve motor function is unclear. Here we examine whether directional and circular differentially change performance in patients with Parkinson’s disease. We measured behaviors 31 who underwent unilateral subthalamic nucleus surgery (SUNDIAL, NCT03353688 ) from each 8 configurations (6 contacts their corresponding rings) during...
ABSTRACT Background Dystonia is an under-studied motor feature of Parkinson disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms PD, whether dystonia associated with specific electrophysiological features unclear. Objectives To investigate subcortical and cortical field potentials at rest during contralateral hand foot movements in PD patients without dystonia. Methods We examined prevalence distribution undergoing deep stimulation...
Runners who rearfoot strike (RFS) may develop more injuries compared to those midfoot or forefoot (non-RFS). Different patterns alter lower extremity joint biomechanics and some of these biomechanical variables have been associated with running injuries. PURPOSE: To establish the relationship between pattern injury-related in male female collegiate runners. METHODS: 24 non-injured runners (11 women) completed five over ground trials. Based on preferred training speeds, men ran at 4.5 m/s...
Old compared to young adults exhibit increased hip and decreased ankle joint work during level walking. This distal-to-proximal redistribution of is known as biomechanical plasticity a successful strategy for maintaining walking performance into old age. It unknown however whether high-functioning adults, (e.g. those with relatively fast speed) larger magnitudes enabling them walk well or low-functioning simply enable walk. The literature weakly suggests that “low-performing”...
Redistribution of mechanical output from the ankle to hip during walking occurs with advanced age. Changes tissues spanning may limit joint performing functions necessary walk at fast speeds and older adults redistribute work proximally compensate. Older Parkinson’s disease (PD) do not exhibit distal-to-proximal redistribution therefore be limited in reaching speeds. We tested whether aging, regardless presence PD, limits ability increase motor-like behavior as speed increases. also healthy...