A5101474422- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- GABA and Rice Research
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Phytochemical compounds biological activities
- Amino Acid Enzymes and Metabolism
- Insect Resistance and Genetics
- Neuroscience and Neural Engineering
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Cancer-related gene regulation
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Analytical Chemistry and Chromatography
- Ion channel regulation and function
- bioluminescence and chemiluminescence research
- Ziziphus Jujuba Studies and Applications
- Histone Deacetylase Inhibitors Research
- Insect Utilization and Effects
- Vagus Nerve Stimulation Research
- Sesquiterpenes and Asteraceae Studies
- Neurobiology and Insect Physiology Research
- EEG and Brain-Computer Interfaces
Sun Yat-sen University
2024
Tianjin University of Traditional Chinese Medicine
2019-2021
Anhui Medical University
2021
Shanghai Jiao Tong University
2012-2019
UPMC Hillman Cancer Center
2019
Sericultural Research Institute
2018
Renji Hospital
2015-2016
Pluchea indica Less. is a medicine and food dual-use plant, which belongs to the genus, Asteraceae family. Its main constituents are quinic acids, flavonoids, thiophenes, phenolic as well sesquiterpenes. In order provide comprehensive chemical profiling of P. indica, an orthogonal chromatography combining reverse-phase BEHC18 column with normal-phase silica separation system ESI-Q-Orbitrap MS detector in both positive negative ion modes were used. According retention time (tR) exact...
The root barks of perennial herb Dictamnus dasycarpus (Cortex Dictamni) were reported to be rich in anti-inflammation activity constituents, limonoids. Then, the investigation therapeutic limonoids from this plant was developed present study. Through combination various chromatographies isolation, six new limonoids, named as dictamlimonol A (1), dictamlimonoside B (2), and dictamlimonols CF (36), along with seven known ones (713) obtained. Their structures ascertained based on extensive...
The phytochemistry, anti-inflammation structural-activity relationships and mechanism were investigated for the triterpenes from fruits of <italic>Ziziphus jujuba</italic> Mill. in this paper.
Abstract Alkenyl oxindoles have been characterized as autophagosome-tethering compounds (ATTECs), which can target mutant huntingtin protein (mHTT) for lysosomal degradation. In order to expand the application of alkenyl targeted degradation, we designed and synthesized a series hetero-bifunctional by conjugating different with BRD4 inhibitor JQ1. Through structure-activity relationship study, successfully developed JQ1-alkenyl oxindole conjugates that potently degrade BRD4. Unexpectedly,...
γ-Aminobutyric acid (GABA), the principle inhibitory transmitter in mature central nervous system, is also involved activities outside system. Recent studies have shown that functional GABA receptors are expressed embryonic stem (ES) cells and these control ES cell proliferation. However, it not clear whether their own GABAergic transmission output machinery can fulfill release or merely process by receiving responding to diffused released elsewhere. To get further insight into this...
Adrenoreceptors (ARs) are widely expressed and play essential roles throughout the body. Different subtype adrenoceptors elicit distinct effects on cell proliferation, but knowledge remains scarce about subtype‐specific of β2‐ARs proliferation embryonic pluripotent stem (PS) cells that represent different characteristics cycle regulation with somatic cells. Herein, we identified a β2‐AR/AC/cAMP/PKA signaling pathway in PS found stimulation inhibited progression involving modulating growth...
// Lin Teng 1, 4, * , Hui-Min Lei Fan Sun 3 Shi-Min An 2 Ya-Bin Tang Shuang Meng 1 Cong-Hui Wang Ying Shen Hong-Zhuan Chen Liang Zhu Department of Pharmacology and Chemical Biology, Basic Medicine Faculty Shanghai Jiao Tong University School Medicine, 200025, China Universities Collaborative Innovation Center for Translational Pharmacy, Renji Hospital Affiliated to 200127, 4 Present address: Cardiology, The First College Clinical Medical Sciences, Three Gorges University, Hubei 443003, These...
This paper describes the design of a peripheral nerve cuff electrodes used to stimulate rat vagus nerve. Multiple on circumference allow for selective stimulation nerve, targeting different functional pathways, including those involved in inflammatory, cardiac, and metabolic diseases. Our approach was verified by stimulating cervical while recording propagated action potentials abdominal The flexible probe adjusts diameter with robust electrode contact maintained an adhesive hydrogel.
Background: In recent years, more and researches have shown that neurotransmitters can also be synthesized released by peripheral non-neural cells. However, specificity high sensitivity detection means were required for confirming ESCs autocrine glutamate γ - aminobutyric acid (GABA). Glutamate GABA are water-soluble polar compounds which cannot retained on a reversed phase C18 column, their contents often at trace level. On the other hand, biological matrix such as cell culture fluid...
Objective: Explore the establishment of a fast, stable and sensitive high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for detecting level m6A modification in RNA its application. Methods: The degree can be expressed as ratio adenosine (A) concentration, which determined by ESI source positive ion multiple reaction monitoring (MRM) mode. established was verified analyzing three quality control samples (m6A: 4, 40, 400 nmol/L; A: 400, 4 000 nmol/L) with...