A5089145229- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Cellular Mechanics and Interactions
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Education Pedagogy and Practices
- Nanoparticle-Based Drug Delivery
- Estrogen and related hormone effects
- RNA Research and Splicing
- Hippo pathway signaling and YAP/TAZ
- Tissue Engineering and Regenerative Medicine
- Metal complexes synthesis and properties
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Mosquito-borne diseases and control
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Health, Education, and Aging
- Science and Education Research
Universidade Federal de Santa Catarina
2013-2021
Universidade de São Paulo
2009-2018
Abstract Perinatal stem cells such as human umbilical cord Wharton's jelly (HWJSCs) are excellent candidates for tissue engineering because of their proliferation and differentiation capabilities. However, potential into epithelial at in vitro vivo levels has not yet been reported. In this work we have studied the capability HWJSCs to differentiate oral mucosa skin using a bioactive three-dimensional model that mimics native epithelial-mesenchymal interaction. To achieve this, primary cell...
Abstract Background Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both vitro vivo conditions. The aim the present study was to determine mechanisms by which gamma-linolenic (GLA) osmotic pump infusion alters glioma proliferation, whether it affects cycle control angiogenesis C6 . Methods Established rat gliomas were treated for 14 days with 5 mM GLA CSF or alone. Tumour size estimated, microvessel density (MVD) counted protein mRNA expression...
Prostaglandin E2 (PGE2) is known to increase glioblastoma (GBM) cell proliferation and migration while cyclooxygenase (COX) inhibition decreases migration. The present study investigated the effects of COX inhibitors PGE2 receptor antagonists on GBM biology. Cells were grown with dose response, viable counting, flow cytometry, migration, gene expression, Western blotting, gelatin zymography studies performed. stimulatory inhibitory ibuprofen (IBP) confirmed in cells. EP2 EP4 receptors...
Abstract Gamma‐linolenic acid (GLA) is an inhibitor of tumor cell proliferation in both vitro and vivo conditions. The aim this study was to investigate the effects 150 μM GLA on expression E2F1, cyclin D1, bax, bcl2, Ku70, Ku80 C6 rat glioma cells. Ku proteins were chosen as previous studies have shown that loss or reduction their causes increased DNA damage micronucleus formation presence radiation. fact exposure known enhance efficacy radiation treatment raised question whether could be...
Glioblastoma is the most common and malignant adult brain tumor. Standard treatment consists of temozolomide (TMZ), surgery radiotherapy (RT) (1). However, despite multimodal treatment, average survival patients with glioma between 9–12 months after initial diagnosis, tumor recurrence almost 100% (2). The main characteristics are: high rates cell proliferation; highly invasive infiltrative across surrounding vessels, myelinated fibres areas necrosis angiogenenic. composed by heterogeneity...
Gliomas account for the majority of primary malignant brain tumors and present invasive behavior into adjacent healthy tissue. While 4-NC had previously shown to induce apoptotic cell death in a melanoma model, glioma model described this paper is cytotoxic cells with induction autophagic pathway. Trypan blue exclusion assay showed that was dose-dependent manner A172 T98G lines. IC10 IC50 values were at 32 µM 41 respectively. Inhibition proliferation observed by total counts cycle analysis...
No Brasil, apesar do acesso ao ensino ser um direito garantido em Lei, a inclusão de pessoas com deficiências no sistema educacional não está ocorrendo na velocidade necessária, seja por falta recursos didáticos ou formação adequada dos educadores. O projeto Extensão Democratização ciências morfológicas: promovendo acessibilidade visuais visa pesquisar e desenvolver material didático adequado, baixo custo fácil reprodução, para o Biologia Celular Histologia deficientes visuais. As matrizes...