Qing Wang

ORCID: 0000-0002-5520-4495
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About
Contact & Profiles
Research Areas
  • Acute Lymphoblastic Leukemia research
  • CAR-T cell therapy research
  • Acute Myeloid Leukemia Research
  • Advanced Photocatalysis Techniques
  • Ammonia Synthesis and Nitrogen Reduction
  • TiO2 Photocatalysis and Solar Cells

University of Michigan
2025

While the mutational landscape across early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and ETP-like is known, establishing a unified framework that activates stem cell genes characteristic of these tumors remains elusive. Using complementary mouse human models, chromatin mapping, enhancer profiling, we show coactivator ZMIZ1 promotes normal malignant ETP population growth by inducing transcription factor MYB in feedforward circuits to convergently activate oncogenes (MEF2C,...

10.1084/jem.20231349 article EN The Journal of Experimental Medicine 2025-02-19
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