A5047321659- Acute Lymphoblastic Leukemia research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- CAR-T cell therapy research
- Chromosomal and Genetic Variations
- Renal and related cancers
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
- Synthesis of Tetrazole Derivatives
- Reproductive Biology and Fertility
- T-cell and Retrovirus Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Cell Function and Interaction
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Acute Myeloid Leukemia Research
- Sperm and Testicular Function
University of Michigan
2020-2025
Michigan State University
2018-2023
Cornell University
2013
Abstract Pachytene piRNAs are the most abundant in mammalian adult testes. They generated from long precursor transcripts by primary piRNA biogenesis pathway but factors involved pachytene precursors processing poorly understood. Here we show that Tudor domain-containing 5 (TDRD5) protein is essential for mice. Conditional inactivation of TDRD5 mouse postnatal germ cells reveals selectively regulates production piRNA-producing precursors, with little effect on low-abundant piRNAs....
While the mutational landscape across early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) and ETP-like is known, establishing a unified framework that activates stem cell genes characteristic of these tumors remains elusive. Using complementary mouse human models, chromatin mapping, enhancer profiling, we show coactivator ZMIZ1 promotes normal malignant ETP population growth by inducing transcription factor MYB in feedforward circuits to convergently activate oncogenes (MEF2C,...
PIWI-interacting RNAs (piRNAs) engage PIWI proteins to silence transposons and promote germ cell development in animals. In diverse species, piRNA biogenesis occurs near the mitochondrial surface, involves membrane-anchored factors. mice, two cytoplasmic proteins, MIWI MILI, receive processed pachytene piRNAs at intermitochodrial cement (IMC). However, how MILI are initially recruited IMC multiple steps of processing is unclear. Here, we show that mitochondria-anchored TDRKH controls mice....
The cytoplasmic droplet is a conserved dilated area of cytoplasm situated at the neck sperm flagellum. Viewed as residual inherited from late spermatids, contains numerous saccular elements its key content. However, origin these saccules and function have long been speculative. Here, we identify molecular components by uncovering vesicle pathway essential for formation sequestration within droplet. This process governed transmembrane protein SYPL1 interaction with VAMP3. Genetic ablation in...
Abstract Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxicities. To circumvent this barrier T-ALL, we aimed inhibit ETS1, a developmentally important transcription factor previously shown cobind response elements. Using complementary genetic approaches mouse models, show that ablation Ets1 leads strong...
Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic clinical trials. To find alternative ways to target signals, we investigated Cell division cycle 73 (Cdc73), which a cofactor and component of transcriptional machinery, potential T-ALL. While confirmed previous work that CDC73 interacts with NOTCH1, also found the interaction T-ALL was context-dependent facilitated by lymphoid transcription factor ETS1. Using...