About
Contact & Profiles
A5067597945
Research Areas
- Epigenetics and DNA Methylation
- Renal and related cancers
- Acute Lymphoblastic Leukemia research
University of Michigan
2020
Abstract Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxicities. To circumvent this barrier T-ALL, we aimed inhibit ETS1, a developmentally important transcription factor previously shown cobind response elements. Using complementary genetic approaches mouse models, show that ablation Ets1 leads strong...
10.1158/2643-3230.bcd-20-0026
article
EN
Blood Cancer Discovery
2020-07-14
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