A5037952044- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Neuroendocrine Tumor Research Advances
- Dermatological and Skeletal Disorders
- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- Diagnosis and treatment of tuberculosis
Boston University
2023-2024
Boston Medical Center
2024
University Medical Center
2024
Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL) but pan-Notch inhibitors were toxic clinical trials. To find alternative ways to target signals, we investigated Cell division cycle 73 (Cdc73), which a cofactor and component of transcriptional machinery, potential T-ALL. While confirmed previous work that CDC73 interacts with NOTCH1, also found the interaction T-ALL was context-dependent facilitated by lymphoid transcription factor ETS1. Using...